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        <PersonNm>Mary Wang start 2719</PersonNm>
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        <PersonNm>Karl B Sharpless</PersonNm>
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        <PersonNm>Steven Steinhubl</PersonNm>
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        <PersonNm>Karl B Sharpless</PersonNm>
        <TitleTxt>Professor</TitleTxt>
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        <PersonNm>Steven Steinhubl</PersonNm>
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        <PersonNm>Travis S Young</PersonNm>
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        <PersonNm>Richard A King End 42017</PersonNm>
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        <PersonNm>Jim C Paulson</PersonNm>
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        <PersonNm>Peter K Vogt</PersonNm>
        <TitleTxt>Professor/Former Exec VP</TitleTxt>
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        <PersonNm>Cary E Thomas</PersonNm>
        <TitleTxt>CIO</TitleTxt>
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        <PersonNm>Kaye I Wynne</PersonNm>
        <TitleTxt>VP Sponsored Programs</TitleTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Part I, Line 1a</FormAndLineReferenceDesc>
        <ExplanationTxt>Business travel and first class travel. The Scripps Research Institute allows for business travel for certain key employees for long haul flights. In certain circumstances, business class service is not available on smaller aircraft. In those circumstances, TSRI allows first class travel. At times TSRI will relocate employees between campuses and will provide a housing allowance for a limited duration to assist with the transition, which was provided to Douglas A. Bingham, Executive Vice President of Scripps Florida. This was paid out based on an agreement with Mr. Bingham and not in accordance with a written policy.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Part I, Line 4a</FormAndLineReferenceDesc>
        <ExplanationTxt>The following individuals received severance payments: Richard A. King $325,000 Kaye I. Wynne $728,595</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Other Information Related to Form 990, Part VII, Line 5:</FormAndLineReferenceDesc>
        <ExplanationTxt>Eric Topol, M.D., received compensation from an unrelated organization, Scripps Clinic Medical Group, for services provided to The Scripps Research Institute. In 2018, in exchange for these services, The Scripps Research Institute reimbursed the Scripps Medical Group $750,000.</ExplanationTxt>
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        <BondReferenceCd>A</BondReferenceCd>
        <IssuerName>
          <BusinessNameLine1Txt>California Infrastructure &amp; Economic Development Bank</BusinessNameLine1Txt>
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        <BondIssuerEIN>630304653</BondIssuerEIN>
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        <BondIssuedDt>2016-08-30</BondIssuedDt>
        <IssuePriceAmt>40511601</IssuePriceAmt>
        <PurposeDesc>See Part VI</PurposeDesc>
        <DefeasedInd>0</DefeasedInd>
        <OnBehalfOfIssuerInd>0</OnBehalfOfIssuerInd>
        <PoolFinancingInd>0</PoolFinancingInd>
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      <TaxExemptBondsProceedsGrp>
        <BondReferenceCd>A</BondReferenceCd>
        <RetiredAmt>6945000</RetiredAmt>
        <TotalProceedsAmt>40511601</TotalProceedsAmt>
        <RefundingEscrowAmt>7079218</RefundingEscrowAmt>
        <IssuanceCostsFromProceedsAmt>648704</IssuanceCostsFromProceedsAmt>
        <UnspentAmt>33072217</UnspentAmt>
        <SubstantialCompletionYr>2016</SubstantialCompletionYr>
        <RefundingTaxExemptBondsInd>1</RefundingTaxExemptBondsInd>
        <RefundingTaxableBondsInd>1</RefundingTaxableBondsInd>
        <FinalAllocationMadeInd>1</FinalAllocationMadeInd>
        <AdequateBooksAndRecMaintInd>1</AdequateBooksAndRecMaintInd>
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      <TaxExemptBondsPrivateBusUseGrp>
        <BondReferenceCd>A</BondReferenceCd>
        <OwningBondFinancedPropertyInd>0</OwningBondFinancedPropertyInd>
        <AnyLeaseArrangementsInd>0</AnyLeaseArrangementsInd>
        <MgmtContractBondFincdPropInd>0</MgmtContractBondFincdPropInd>
        <AnyResearchAgreementsInd>1</AnyResearchAgreementsInd>
        <EngageBondCounselResearchInd>0</EngageBondCounselResearchInd>
        <PrivateBusUseByOthersPct>0.00000</PrivateBusUseByOthersPct>
        <PrivateBusConcerningUBIPct>0.00000</PrivateBusConcerningUBIPct>
        <TotalPrivateBusinessUsePct>0.00000</TotalPrivateBusinessUsePct>
        <BondIssMeetPrvtSecPymtTestInd>0</BondIssMeetPrvtSecPymtTestInd>
        <ChangeInUseBondFinancedPropInd>0</ChangeInUseBondFinancedPropInd>
        <ProcsNonqualifiedBondRemdtdInd>1</ProcsNonqualifiedBondRemdtdInd>
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        <BondReferenceCd>A</BondReferenceCd>
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        <ExceptionToRebateInd>0</ExceptionToRebateInd>
        <NoRebateDueInd>0</NoRebateDueInd>
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        <GrossProceedsInvestedInd>0</GrossProceedsInvestedInd>
        <WrittenProcToMonitorReqsInd>1</WrittenProcToMonitorReqsInd>
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        <BondReferenceCd>A</BondReferenceCd>
        <ProceduresCorrectiveActionInd>1</ProceduresCorrectiveActionInd>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Schedule K, Part I, Bond Issues:</FormAndLineReferenceDesc>
        <ExplanationTxt>(a) Issue Name: California Infrastructure &amp; Economic Development Bank (f) Description on Purpose: Refund and defease bonds previously issued for the benefit of the Institute on 06/29/2000 and and 02/23/2005.</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Schedule K, Part III, Line 3d:</FormAndLineReferenceDesc>
        <ExplanationTxt>Overall private use isn't material and outside counsel would review any significant agreements.</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Schedule K, Part IV, Line 6:</FormAndLineReferenceDesc>
        <ExplanationTxt>This question is being answered without regard to a yield-restricted advance refunding escrow financed with proceeds of the bonds.</ExplanationTxt>
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        <NameOfInterested>
          <BusinessName>
            <BusinessNameLine1Txt>Joel S Marcus</BusinessNameLine1Txt>
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        </NameOfInterested>
        <RelationshipDescriptionTxt>Member of the Board of Directors - The Scripps Research Institute</RelationshipDescriptionTxt>
        <TransactionAmt>8611339</TransactionAmt>
        <TransactionDesc>See Part V</TransactionDesc>
        <SharingOfRevenuesInd>0</SharingOfRevenuesInd>
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      <BusTrInvolveInterestedPrsnGrp>
        <NameOfInterested>
          <BusinessName>
            <BusinessNameLine1Txt>Ge Li</BusinessNameLine1Txt>
          </BusinessName>
        </NameOfInterested>
        <RelationshipDescriptionTxt>Member of the Board of Directors - The Scripps Research Institute</RelationshipDescriptionTxt>
        <TransactionAmt>2766579</TransactionAmt>
        <TransactionDesc>See Part V</TransactionDesc>
        <SharingOfRevenuesInd>0</SharingOfRevenuesInd>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Sch L, Part IV, Business Transactions Involving Interested Persons:</FormAndLineReferenceDesc>
        <ExplanationTxt>(a) Name of Person: Joel S. Marcus(b) Relationship Between Interested Person and Organization: Member of the Board of Directors - The Scripps Research Institute(c) Amount of Transaction $8,611,339.(d) Description of Transaction: The Scripps Research Institute (TSRI) leases office and laboratory space building from Alexandria Real Estate (ARE). Joel S. Marcus is the Executive Chairman &amp; Founder of ARE. Mr. Marcus was appointed to TSRI'S Board as of May 2017. Lease commenced in November 1997, at which time, the property was not owned by ARE and Mr. Marcus was not a member of TSRI'S Board.(e) Sharing of Organization Revenues? = No(a) Name of Person: Ge Li(b) Relationship Between Interested Person and Organization: Member of the Board of Directors - The Scripps Research Institute(c) Amount of Transaction $2,766,579.(d) Description of Transaction: California Institute for BioMedical Research (CALIBR) a division of The Scripps Research Institute (TSRI) has contracts with outside parties for outsourced research services. Ge Li is the Chairman and Chief Executive Officer at Wuxi Companies which is one of the contracted parties to provide outsourced research services. CALIBR began working with Wuxi in 2013, at which time Mr. Li was not a member of TSRI or CALIBR's Board. Wuxi Companies and TSRI or Calibr do not share revenue.(e) Sharing of Organization Revenues? = No</ExplanationTxt>
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      <SecuritiesPubliclyTradedGrp>
        <NonCashCheckboxInd>X</NonCashCheckboxInd>
        <ContributionCnt>12</ContributionCnt>
        <NoncashContributionsRptF990Amt>4041630</NoncashContributionsRptF990Amt>
        <MethodOfDeterminingRevenuesTxt>Cost or Selling Price</MethodOfDeterminingRevenuesTxt>
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      <Form8283ReceivedCnt>0</Form8283ReceivedCnt>
      <AnyPropertyThatMustBeHeldInd>0</AnyPropertyThatMustBeHeldInd>
      <ReviewProcessUnusualNCGiftsInd>1</ReviewProcessUnusualNCGiftsInd>
      <ThirdPartiesUsedInd>1</ThirdPartiesUsedInd>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Part I, Column (b):</FormAndLineReferenceDesc>
        <ExplanationTxt>Securities - Publicly traded - No. of contributions</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Part I, Line 32b:</FormAndLineReferenceDesc>
        <ExplanationTxt>Shares of stock gifted to TSRI are transferred into our brokerage account at Morgan Stanley and they in turn sell the shares and wire proceeds to TSRI.</ExplanationTxt>
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    </IRS990ScheduleM>
    <IRS990ScheduleO documentId="RetDoc1044400001">
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI, Section B, line 11b</FormAndLineReferenceDesc>
        <ExplanationTxt>On June 17, 2020, the Audit Committee reviewed a draft of the Form 990 (including all supplemental schedules). This review included a presentation of the statements by the Chief Financial Officer with particular emphasis on disclosures about governance and about transactions with interested persons. The 990 will be provided to the full Board of Directors prior to filing.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI, Section B, line 12c</FormAndLineReferenceDesc>
        <ExplanationTxt>TSRI'S Conflict of Interest Policies and Procedures apply to members of the Board of Directors, officers, key personnel, and their family members (altogether covered individuals) to protect the interests of TSRI when it is contemplating entering into a transaction or arrangement that could: 1) Benefit the private interest of a covered individual within the meaning of Treasury Regulation Section 1.501(c)(3)-1(d)(1)(ii), 2) Result in a possible excess benefit transaction within the meaning of Section 4958(c) of the Internal Revenue Code of 1986, as amended; or 3) Be a self-dealing transaction within the meaning of Section 5233 of the California Corporations Code (the "Corporations Code"). TSRI's policies and procedures are intended to supplement, but not replace, any state and federal laws governing actual, potential, or apparent conflict of interest applicable to TSRI. Disclosure documents responsive to TSRI's policies are annually submitted by covered individuals, and are reviewed by TSRI administration for pertinent relationships. Any transactions or arrangements involving covered individuals that fall within the scope of the policies are then subject to review and consideration by non-conflicted Board of Director members, with conflicted members being recused from any debate and vote to approve or disapprove.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI, Section B, line 15</FormAndLineReferenceDesc>
        <ExplanationTxt>The compensation of the CEO and certain other key executives was reviewed and approved by the Board of Directors. This review was based, in part, on analysis performed by the Human Resources department, and included data from outside consultants or internally-conducted research. On an ongoing basis, executives may participate in the normal annual salary increase program, which is based on a recommendation from the Human Resources department based on market research. Any unusual or potentially non-qualified compensation would be reviewed by outside counsel for any tax compliance issues.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI, Section C, line 19</FormAndLineReferenceDesc>
        <ExplanationTxt>Governing documents and Conflict of Interest Policies are not available to the public at this time. The financial statements are filed with the State of Florida by The Scripps Florida Funding Corporation. The statements are provided to bond holders through TSRI's dissemination agent. The annual information return is provided upon request.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part IX, line 11g</FormAndLineReferenceDesc>
        <ExplanationTxt>Purchase Services and Maintenance: Program service expenses 96,022,814. Management and general expenses 2,663,930. Fundraising expenses 139,116. Total expenses 98,825,860.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part XI, line 9:</FormAndLineReferenceDesc>
        <ExplanationTxt>Calibr Fund Balance 64,477,830.</ExplanationTxt>
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    </IRS990ScheduleO>
    <IRS990ScheduleR documentId="RetDoc1043400001">
      <IdDisregardedEntitiesGrp>
        <DisregardedEntityName>
          <BusinessNameLine1Txt>STRIDE LLC</BusinessNameLine1Txt>
        </DisregardedEntityName>
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          <AddressLine1Txt>10550 North Torrey Pines Rd</AddressLine1Txt>
          <CityNm>La Jolla</CityNm>
          <StateAbbreviationCd>CA</StateAbbreviationCd>
          <ZIPCd>92037</ZIPCd>
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