2020-07-15T12:14:47-05:00 2019-06-30 ERNST & YOUNG US LLP 4365 EXECUTIVE DR SUITE 1600 SAN DIEGO CA 92121 990 2018-07-01 952160097 THE SALK INSTITUTE FOR BIOLOGICAL STUDIES % KIMBERLY CASTILLO SALK 8584534100 10010 N TORREY PINES ROAD LA JOLLA CA 920371002 KIM E WITMER TREAS/SVP FIN/ADMIN 8584534100 2020-07-15 true JOCELYNE MILLER P00634378 8585357200 181.197.206.199 33008120201975000010 2020-07-15 P A28EF63478773B3BBBA2AFA46E06610B1A340BD5 DE6C2DF5A9AF955A85F13E615B2394729CA127AA 2018 2021-01-29 14:40:06Z FRED GAGE 10010 N TORREY PINES ROAD LA JOLLA CA 920371002 316156034 false X WWW.SALK.EDU X 1960 CA BASIC RESEARCH IN THE FOLLOWING: MOLECULAR BIOLOGY & GENETICS, NEUROSCIENCE, AND PLANT BIOLOGY. 31 28 1151 224 -425157 0 118876121 166283728 0 0 22544429 22559342 1161189 473397 142581739 189316467 0 0 0 0 70829123 75666308 0 0 5597759 54781095 61324385 125610218 136990693 16971521 52325774 521318368 577444867 117889210 120028415 403429158 457416452 X INVOLVED IN RESEARCH ACTIVITIES, THE OBJECTIVES OF WHICH ARE THE ADVANCEMENT AND DISSEMINATION OF KNOWLEDGE RELEVANT TO THE HEALTH AND WELLBEING OF MAN. THE OBJECTIVES ARE MET PRIMARILY THROUGH RESEARCH AND ADVANCED INSTRUCTION IN (A) BIOLOGY, (B) THE CAUSE, PREVENTION AND CURE OF DISEASES, AND (C) THE FACTORS AND CIRCUMSTANCES CONDUCIVE TO THE FULFILLMENT OF MAN'S BIOLOGICAL POTENTIAL. false false 115554471 0 0 Salk scientists discover how satellite RNA leads to cancer - Only some of us have satellite TV in our homes, but all of us have satellite DNA in our bodies-short, repetitive DNA sequences near the middle and ends of chromosomes. Working copies of satellite DNA, known as satellite RNA, is high in some cancers. Salk scientists discovered that a specific type of satellite RNA called hSATa induces breast cancer by directly interfering with DNA copying and damage repair. The research appeared in the journal Molecular Cell on June 7. [7/2/2018] Salk-led study clarifies dual role of protein that watches for cellular threats and repairs damage - Salk Professor Gerald Shadel and collaborators found that a protein called ATM can sense the presence of toxins called reactive oxygen species and responds by sounding the alarm to trigger the production of antioxidants. The work, which appeared in Science Signaling on July 10, could have implications for a disease in which ATM is dysfunctional-and could also reveal ways to boost cellular health overall. [7/10/2018] Depleting microbiome with antibiotics can affect glucose metabolism - A study from the Salk Institute found that mice that have their microbiomes depleted with antibiotics have decreased levels of glucose in their blood and better insulin sensitivity. The research has implications for understanding the role of the microbiome in diabetes. It also could lead to better insight into the side effects seen in people who are being treated with high levels of antibiotics. The study appeared in the journal Nature Communications on July 20, 2018. [7/23/18] Widespread connections among neurons help the brain distinguish smells - Salk Institute researchers illuminated how the randomness of the brain region called the piriform cortex is actually critical to how the brain distinguishes between similar odors. In addition to better understanding how smells are processed, the research, published in the Journal of Comparative Neurology on July 17, 2018, could also lead to greater insight into how some parts of the brain organize information. [7/24/18] Salk researchers identify genetic characteristics of fetal stem cells that may lead to breast cancer later in life - Professor Geoffrey Wahl's team uncovered a reason for the uncanny likeness between cells in the most malignant cancers and the embryonic cells of the organ in which the cancer originated: cells in human basal-like breast cancers share features with the embryonic mammary (breast) stem cells that are the progenitors of all cell types in the mammary gland (of a mouse). The insights leading to this conclusion were published in the journal Cell Reports. [8/7/18] Salk scientists find that common dietary elements cure lethal infections, eliminating the need for antibiotics - The lab of Professor Janelle Ayres reported that giving mice dietary iron supplements enabled them to survive a normally lethal bacterial infection and resulted in later generations of those bacteria being less virulent. The approach, which appeared in the journal Cell, demonstrated in preclinical studies that non-antibiotic-based strategies-such as nutritional interventions-can shift the relationship between the patient and pathogens away from antagonism and toward cooperation. [8/9/18] Salk scientists show that cells adapt to brief stressors by boosting antioxidants and energy production longer term - Research led by Professor Gerald Shadel suggested why, at a cellular level the expression "what doesn't kill you makes you stronger" might be true. His team found that brief exposures to stressors can be beneficial by prompting the cell to trigger sustained production of antioxidants, molecules that help get rid of toxic cellular buildup related to normal metabolism. The research, which appeared in Cell Metabolism, could lead to new approaches to counter the cellular effects of aging. [8/16/18] Researchers discover key to mass-producing beneficial plant compounds - Salk Institute researchers in Professor Joseph Noel's lab, together with Purdue University scientists, discovered the switch in plants that turns off production of terpenoids-carbon-rich compounds that play roles in plant physiology and are used by humans in everything from fragrances and flavorings to biofuels and pharmaceuticals. The findings were reported in the journal Nature Plants. [8/21/18] Scientists find a new way to understand odors - Professor Tatyana Sharpee and collaborators discovered a new way to organize odor molecules based on how often they occur together in nature. The findings, published in Science Advances, open new avenues for engineering smells and tastes. [8/29/18] Eating in 10-hour window can override disease-causing genetic defects, nurture health - The lab of Professor Satchidananda Panda found that mice lacking the biological clocks thought to be necessary for a healthy metabolism could still be protected against obesity and metabolic diseases by having their daily access to food restricted to a 10-hour window. The work appeared in the journal Cell Metabolism and suggests that the health problems associated with disruptions to circadian rhythms can be corrected by eating all calories within this time frame. [8/30/18] Salk team finds that master switch controls aggressive breast cancer - Professor Geoffrey Wahl's lab identified a genetic master switch that appears to control the dynamic behavior of tumor cells that makes some aggressive cancers, such as triple-negative breast cancers, difficult to treat. The work appeared in Cancer Cell. [8/30/18] Salk scientists develop new technique to heal large ulcers by reprogramming wound cells into skin cells - The lab of Professor Juan Carlos Izpisua Belmonte developed a technique to directly convert the cells in an open wound into new skin cells by reprogramming the cells to a stem-cell-like state. The work, which appeared in Nature, could be useful for healing skin damage and countering the effects of aging. [9/5/18] Electron microscopy provides new view of tiny virus with therapeutic potential - Assistant Professor Dmitry Lyumkis and collaborators used cryo-electron microscopy (cryo-EM) to show the structure of a version of a virus called an AAV2, advancing the virus' potential as a delivery vehicle for gene therapies. The paper was published in Nature Communications. [9/7/18] New method of pinpointing cancer mutations could lead to more targeted treatments - The lab of Helmsley-Salk Fellow Jesse Dixon and collaborators developed a new framework that can combine three existing methods of finding large mutations in cells' DNA-called structural variants-into a single, more complete picture of cancer. The study was detailed in Nature Genetics. [9/10/18] Research in yeast leads to serendipitous finding about a central nervous system disorder - The lab of Tony Hunter found that a quality control mechanism in baker's yeast cells is closely connected to hypomyelinating leukodystrophy, a debilitating disease found in children. The finding, which appeared in eLife, could have relevance for addressing multiple sclerosis and other neurodegenerative diseases. [9/13/18] Salk scientists develop method to manipulate numbers of nuclear pores - The lab of Martin Hetzer devised a way to manipulate numbers of cellular access points called nuclear pores. Targeting nuclear pores could negate aggressive cancer's resistance to multiple drugs, as higher numbers of nuclear pores in tumor cells allow them to export chemotherapy out of the nuclei. The discovery, which was published in Genes & Development, may point to ways to stop cancerous cells from proliferating out of control. [9/18/18] Researchers train robotic gliders to soar - Salk Professor Terrence Sejnowski and collaborators at UC San Diego used reinforcement learning to train gliders to autonomously navigate atmospheric thermals. The work was published in Nature and could inform the development of unmanned aerial vehicles. [9/19/18] Salk Institute researchers uncover molecular details of a new genetic engineering tool - Scientists from the Salk Institute reported for the first time the detailed molecular structure of CRISPR-Cas13d, a promising enzyme for emerging RNA-editing technology. They were able to visualize the enzyme thanks to cryo-electron microscopy (cryo-EM), a cutting-edge technology that enables researchers to capture the structure of complex molecules in unprecedented detail. The findings were reported September 20, 2018, in the journal Cell. [9/20/18] Protein made by astrocytes enables the brain's maturation and regulates its flexibility - In a study published in Neuron, Associate Professor Nicola Allen showed that astrocytes-long-overlooked supportive cells in the brain-help to enable the brain's plasticity, a new role for astrocytes that was not previously known. The findings could point to ways to restore connections that have been lost due to aging or trauma. [10/18/18] Genetic "whodunnit" fo 115554471 true true false true false false false false false true true true false false true false true false false false true false false false true false false false false true true false false false false false true false false false false true false false false false true true false false false true 137 0 true 1151 true true true false false false false true true false false false false false false X 31 28 false false false false true true true true true false false false true true true true true true true false AL AK AZ AR CA CT GA HI IL KS KY ME MD MA MI MN MS NH NJ NM NY NC OH OK OR PA RI SC TN UT VA WA WV WI X X KIMBERLY CASTILLO 8584534100 10010 N TORREY PINES ROAD LA JOLLA CA 920371002 X IRWIN M JACOBS SM SCD CHAIR EMERITUS 2.0 0.0 X 0 0 0 M FAYE WILSON TRUSTEE 0.5 0.0 X 0 0 0 DANIEL C LEWIS CHAIR 3.0 0.0 X X 0 0 0 MARNA WHITTINGTON PHD VICE CHAIR 2.0 0.0 X X 0 0 0 RICHARD A HEYMAN PHD VICE CHAIR 2.0 0.0 X X 0 0 0 DONALD L COHN TRUSTEE 0.5 0.0 X 0 0 0 FREDERICK J DOTZLER TRUSTEE 2.0 0.0 X 0 0 0 JAY FLATLEY TRUSTEE 0.5 0.0 X 0 0 0 ALAN D GOLD TRUSTEE 0.5 0.0 X 0 0 0 DAVID F HALE TRUSTEE 0.5 0.0 X 0 0 0 EDWIN K HUNTER TRUSTEE 0.5 0.0 X 0 0 0 SANJAY K JHA PHD TRUSTEE 2.0 0.0 X 0 0 0 ELIZABETH KEADLE TRUSTEE 2.0 0.0 X 0 0 0 BENJAMIN H LEWIS TRUSTEE 0.5 0.0 X 0 0 0 CORINNE MENTZELOPOULOS TRUSTEE 0.5 0.0 X 0 0 0 HOWARD H NEWMAN PHD TRUSTEE 2.0 0.0 X 0 0 0 JOSEPH NOEL PHD TRUSTEE/PROFESSOR 0.5 0.0 X 5000 0 0 FREDERIK PAULSEN PHD TRUSTEE 0.5 0.0 X 0 0 0 ERNEST S RADY TRUSTEE 0.5 0.0 X 0 0 0 MARKUS REINHARD TRUSTEE 0.5 0.0 X 0 0 0 TERRY ROSEN PHD TRUSTEE 0.5 0.0 X 0 0 0 ERIC SAGERMAN TRUSTEE 0.5 0.0 X 0 0 0 MARY JANE SALK TRUSTEE 0.5 0.0 X 0 0 0 BENJAMIN S SCHAPIRO TRUSTEE 2.0 0.0 X 0 0 0 STACEY STEWART TRUSTEE 0.5 0.0 X 0 0 0 HAEYOUNG KONG TANG PHD TRUSTEE 0.5 0.0 X 0 0 0 DANIEL TIERNEY TRUSTEE 0.5 0.0 X 0 0 0 JOON YUN MD TRUSTEE 0.5 0.0 X 0 0 0 FRED GAGE PHD PRESIDENT/PROFESSOR 50.0 0.0 X X 812436 0 43231 JAN KARLSEDER PHD TRUSTEE/PROFESSOR 50.0 0.0 X 246460 0 31175 DAVID DOLBY TRUSTEE 0.5 0.0 X 0 0 0 MARK KNICKREHM TRUSTEE 0.5 0.0 X 0 0 0 IRVING WEISSMAN MD TRUSTEE 0.5 0.0 X 0 0 0 GERALD SHADEL PHD TRUSTEE/PROFESSOR 50.0 0.0 X 213450 0 3569 JULIA A MILLER JD SECRETARY/GENERAL COUNSEL 50.0 0.0 X 338332 0 46978 KIM E WITMER TREASURER/SVP FINANCE & ADMIN 50.0 0.0 X 424778 0 41707 KIMBERLY CASTILLO CHIEF FINANCIAL OFFICER 50.0 0.0 X 278143 0 46578 MARTIN HETZER PHD PROFESSOR/CSO 50.0 0.0 X 446600 0 40278 REBECCA NEWMAN VP, EXTERNAL RELATIONS 50.0 0.0 X 442852 0 33797 VICTORIA LUNDBLAD PHD PROFESSOR 50.0 0.0 X 398054 0 39533 REUBEN SHAW PHD PROFESSOR 50.0 0.0 X 376280 0 40729 KATHERINE JONES PHD PROFESSOR 50.0 0.0 X 373927 0 44794 ELIZABETH BLACKBURN PHD FORMER PRESIDENT/PROFESSOR 50.0 0.0 X 576136 0 33465 4932448 0 445834 118 true true false COOLEY LLP ONE MARITIME PLAZA 20TH FLOOR SAN FRANCISCO CA 94111 LEGAL SERVICES 3642137 UC REGENTS SAN DIEGO 9500 GILMAN DRIVE LA JOLLA CA 92093 TRNG PROGRAM/SUBCONT 1668190 AO REED CO 4777 RUFFNER STREET SAN DIEGO CA 92111 CONSTRUCTION SVCS 454267 ALLIED UNIVERSAL SECURITY SERVICES EIGHT TOWER BRIDGE 161 WASHINGTON CONSHOHOCKEN PA 19428 SECURITY SERVICE 406495 LAK PUBLIC RELATIONS INC 1251 AVENUE OF THE AMERICAS NEW YORK NY 10020 PUBLIC RELATIONS SVC 272264 10 671928 71765660 93846140 910846 166283728 0 4056846 4056846 0 1103503 1103503 0 0 0 145000766 126498270 18502496 18502496 18502496 131223 671928 341297 -210074 -210074 0 0 0 0 0 0 OIL ROYALTIES 900099 1545 1545 UBI(K-1 FLOW THROUGH INCOME) 900099 -425157 -425157 GIFT SHOP 900099 2302 2302 1278 1278 -420032 189316467 -425157 23457896 0 0 0 0 2531838 897931 1546164 87743 0 57247193 48968204 5508542 2770447 4016884 3354380 429123 233381 7872109 6702090 840976 329043 3998284 3338847 427136 232301 502850 92273 410149 428 1758956 317607 1440292 1057 198674 198674 0 0 117132 117132 12429145 11144146 897856 387143 52631 14538 14797 23296 1175290 328070 312306 534914 1929948 1451189 328035 150724 0 7066723 5798334 1115682 152707 1033630 854570 55323 123737 0 1567628 1013522 151896 402210 16048 16048 0 10526093 9515833 854227 156033 298709 298709 SCIENTIFIC SUBCONTRACTS 4843931 4843931 RESEARCH SUPPLIES 16664269 16664269 REPAIRS & PARTS 261222 254737 5321 1164 UBI TAXES 52784 52784 828722 817291 11431 136990693 115554471 15838463 5597759 20160025 16271743 0 0 21524172 62469315 1111195 718854 597500 932500 0 0 3050590 3252808 95709 19152 1234017 1332549 250804527 179978295 72407365 70826232 127416856 101423379 269897178 316276055 0 0 0 0 3823761 3922280 521318368 577444867 20565426 19959088 0 0 25802889 30818376 29668666 28861374 0 0 0 0 35884256 35071557 0 0 5967973 5318020 117889210 120028415 X 86081598 88339929 125960157 135676127 191387403 233400396 403429158 457416452 521318368 577444867 X 52325774 693577 967943 X false true X true true true X 106020719 101155413 117967625 118871121 166753206 610768084 0 0 106020719 101155413 117967625 118871121 166753206 610768084 32549977 578218107 8686425 5072963 2181811 608347 5160349 21709895 12021 45497 22341 79859 185573 174543 70625 8647 5125 444513 633002351 0.91345 0.89962 X OTHER INCOME SCHEDULE A, PART II, LINE 10 Description: OIL ROYALTIES 2014: 4,629 2015: 2,022 2016: 1,714 2017: 1,652 2018: 1,545 Description: ENERGY REBATE 2014: 179,409 2015: 169,137 2016: 65,276 2017: 0 2018: 0 Description: REVENUE SHARING-HOST VEHICLE CHARGING STATION 2014: 690 2015: 0 2016: 0 2017: 4,688 2018: 1,278 Description: NET GIFT SHOP SALES 2014: 845 2015: 3,384 2016: 3,635 2017: 2,307 2018: 2,302 RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED false false false false false false false false true 2730 2730 false OTHER ACTIVITIES PART II-B, LINE 1 PAID MEMBERSHIP DUES TO RESEARCH AND BIOMEDICAL ORGANIZATIONS, A PORTION OF WHICH ARE CONSIDERED LOBBYING. ASSOCIATION OF INDEPENDENT RESEARCH INSTITUTES - $1,200, NATIONAL ASSOCIATION FOR BIOMEDICAL RESEARCH - $1,200, BIOCOM - $330. 240056992 42422494 14937417 10582141 286834762 228968520 4591674 15038371 8541573 240056992 207522930 10092267 18861980 7508657 228968520 218699419 6197345 -10186871 7186963 207522930 218629544 5364024 1892814 7186963 218699419 0.01600 0.98400 0.00000 false false 1153930 1153930 64209980 48303294 15906686 96673992 61849626 34824336 87462645 68563185 18899460 1303980 1262190 41790 70826232 ALTERNATIVE INVESTMENTS 316273044 F STOCKS NOT-PUBLICLY TRADED <5% 3011 C 316276055 4981 DEFERRED RETIREE MEDICAL OBLIG 5313039 5318020 184062676 693577 -6713822 -6020245 190082921 -766454 -766454 189316467 137331990 341297 341297 136990693 136990693 ENDOWMENT FUNDS USES PART V, LINE 4 ENDOWMENT INCOME INTENDED TO BE USED FOR AND TO SUPPORT RESEARCH, OPERATIONS, AND LECTURESHIP EXPENSES. RECONCILIATION OF REVENUE PER AUDITED FS WITH REVENUE PER RETURN PART XI, LINE 2D INVESTMENT RETURN IN EXCESS OF AMOUNT DESIGNATED FOR CURRENT OPERATIONS UNDER SPENDING POLICY AND ROUNDING. Reconciliation of Revenue per Audited FS with Revenue per Return PART XI, LINE 4B FUNDRAISING EVENTS EXPENSES AND UNRELATED BUSINESS INCOME. Reconciliation of Expenses per Audited Financial Stmts w Expenses per Rtn PART XII, LINE 2D FUNDRAISING EVENTS EXPENSES. Europe (Including Iceland and Greenland) Program Services Attended conference 147515 East Asia and the Pacific Program Services Attended conference 82422 Middle East and North Africa Program Services Attended conference 5412 South America Program Services Attended conference 2095 South Asia Program Services Attended conference 2121 North America Program Services Attended conference 38194 Europe (Including Iceland and Greenland) Fundraising 16753 Central America and the Caribbean Investments 130297421 Europe (Including Iceland and Greenland) Investments 26314018 Sub-Saharan Africa Investments 13650830 North America Investments 1446988 172003769 172003769 true false true true true false NO. OF EMPLOYEES IN THE REGION PART I, LINE 3, COLUMN (C) SCIENTISTS TRAVEL TO FOREIGN COUNTRIES TO ATTEND CONFERENCES. WE DO NOT DEEM THESE ACTIVITIES TO CONSTITUTE WORKING IN THE REGION. ACCOUNTING METHOD PART I, LINE 3, COLUMN (F) ACCRUAL METHOD CONCERT 723530 640180 83350 109913 199000 LECTURE/MUSIC 79621 31748 47873 2133 30250 0 0 0 0 0 0 0 0 0 0 803151 671928 131223 0 0 0 112046 229250 0 341296 -210073 X true true X X X X X X false false false false false false false false false JULIA A MILLER JD SECRETARY/GENERAL COUNSEL 313632 0 0 0 24700 0 33000 0 13978 0 385310 0 0 0 KIM E WITMER TREASURER/SVP FINANCE & ADMIN 392734 0 0 0 32044 0 33000 0 8707 0 466485 0 0 0 MARTIN HETZER PHD PROFESSOR/CSO 389690 0 0 0 56910 0 27500 0 12778 0 486878 0 0 0 FRED GAGE PHD PRESIDENT/PROFESSOR 796268 0 0 0 16168 0 33000 0 10231 0 855667 0 0 0 REBECCA NEWMAN VP, EXTERNAL RELATIONS 385760 0 0 0 57092 0 33000 0 797 0 476649 0 0 0 KIMBERLY CASTILLO CHIEF FINANCIAL OFFICER 270008 0 0 0 8135 0 33000 0 13578 0 324721 0 0 0 JAN KARLSEDER PHD TRUSTEE/PROFESSOR 221092 0 0 0 25368 0 26776 0 4399 0 277635 0 0 0 GERALD SHADEL PHD TRUSTEE/PROFESSOR 208333 0 0 0 5117 0 3542 0 27 0 217019 0 0 0 ELIZABETH BLACKBURN PHD FORMER PRESIDENT/PROFESSOR 454860 0 0 0 121276 0 33000 0 465 0 609601 0 0 0 VICTORIA LUNDBLAD PHD PROFESSOR 388769 0 0 0 9285 0 29302 0 10231 0 437587 0 0 0 REUBEN SHAW PHD PROFESSOR 225805 0 0 0 150475 0 28290 0 12439 0 417009 0 0 0 KATHERINE JONES PHD PROFESSOR 366227 0 0 0 7700 0 32015 0 12778 0 418720 0 0 0 QUESTIONS REGARDING COMPENSATION PART I, LINE 1A FIRST-CLASS OR CHARTER TRAVEL: FRED GAGE, PRESIDENT/PROFESSOR - $18,731; JAN KARLSEDER, PROFESSOR - $12,017; REBECCA NEWMAN, VP EXTERNAL RELATIONS - $5,007. NOT TAXABLE - ACCOUNTABLE PLAN. A CA STATEWIDE COMM DEV AUTHORITY 680164610 2014-08-07 31081050 REFUND 08/11/05 ISSUE; RENOVATE/EQ false false false A 1946642 0 31081050 0 0 0 0 0 0 15000000 16081050 0 2018 true false true true A false false false false 0 false false false true A false false false true false false 0 false 0 false true A true SCHEDULE K, PART IV, LINE 2C THE REBATE CALCULATION WAS LAST PERFORMED ON 05/10/2015. MARTIN HETZER PROFESSOR HOME LOAN X 400000 400000 false true true MARTIN HETZER PROFESSOR HOME LOAN X 92500 92500 false true true JAN KARLSEDER PROFESSOR HOME LOAN X 200000 120000 false true true GERALD SHADEL PROFESSOR HOME LOAN X 300000 270000 false true true 882500 X 17 910846 MARKET VALUE false true false NUMBER OF CONTRIBUTIONS PART I, COLUMN B THE AMOUNT REPORTED IN THIS COLUMN REPRESENTS THE NUMBER OF CONTRIBUTIONS. GOVERNING BODY AND MANAGEMENT FORM 990, PART VI, SECTION A, LINES 1A, 6, 7A, 7B LINE 1A: THE EXECUTIVE COMMITTEE SHALL ADVISE AND AID THE OFFICERS OF THE CORPORATION IN ALL MATTERS CONCERNING ITS INTERESTS, INCLUDING WITHOUT LIMITATION ALL MATTERS RELATING TO COMPENSATION AND BENEFITS, AND SHALL POSSESS AND MAY EXERCISE, DURING THE INTERVALS BETWEEN THE MEETINGS OF THE BOARD OF TRUSTEES, ALL THE POWERS AND AUTHORITY OF THE BOARD OF TRUSTEES IN THE MANAGEMENT OF THE BUSINESS AND AFFAIRS OF THE CORPORATION, INCLUDING THE POWER TO AUTHORIZE THE CORPORATE SEAL TO BE AFFIXED TO ANY AND ALL DOCUMENTS WHICH MAY REQUIRE THE SAME TO BE AFFIXED THERETO, INSOFAR AS SUCH SEEMS TO THE EXECUTIVE COMMITTEE FOR THE BEST INTERESTS OF THE CORPORATION, IN ALL CASES IN WHICH SPECIFIC DIRECTIONS SHALL NOT HAVE BEEN GIVEN BY THE BOARD OF TRUSTEES, EXCEPT THAT THE EXECUTIVE COMMITTEE SHALL HAVE NO POWER TO ADOPT, AMEND, OR REPEAL THE BY-LAWS. LINE 6: MEMBERSHIP OF THE CORPORATION CONSISTS OF THE PERSONS ELECTED TO THE BOARD OF TRUSTEES AND THREE MEMBERS FROM AMONG THE RESIDENT AND NON-RESIDENT FELLOWS AND PROFESSORS CHOSEN AND ELECTED ANNUALLY BY THE RESIDENT AND NON-RESIDENT FELLOWS AND PROFESSORS. LINE 7A: THE MEMBERS OF THE CORPORATION ELECT THE TRUSTEES. LINE 7B: THE MEMBERS OF THE CORPORATION MAY ALTER, AMEND, OR REPEAL THE BY-LAWS BY VOTE. POLICIES FORM 990, PART VI, SECTION B, LINES 11B, 12C, 15A/B LINE 11B: THE FORM 990 IS PREPARED BY THE INSTITUTE, INTERNALLY REVIEWED BY THE CHIEF FINANCIAL OFFICER AND EXTERNALLY REVIEWED BY THE TAX DEPARTMENT OF A PUBLIC ACCOUNTING FIRM. PRIOR TO ELECTRONIC FILING, A COPY OF THIS FORM 990 WAS PROVIDED TO AND DISCUSSED IN EXECUTIVE SESSION BY THE EXECUTIVE COMMITTEE OF THE BOARD OF TRUSTEES. LINE 12C: ANNUALLY, THE CONFLICT OF INTEREST DISCLOSURE STATEMENT IS SENT OUT FOR COMPLETION BY THE MEMBERS OF THE BOARD OF TRUSTEES, SENIOR MEMBERS OF ADMINISTRATION AND RESEARCHERS. THE DESIGNATED OFFICIAL FOR EACH GROUP REVIEWS THE COMPLETED FORMS AND BRINGS ANY POTENTIAL CONFLICT OF INTEREST TO THE RESPECTIVE COMMITTEES FOR REVIEW. UPON DETERMINATION THAT A CONFLICT OF INTEREST EXISTS, THE FOLLOWING CONDITIONS OR RESTRICTIONS MAY BE IMPOSED: A. MONITORING OF ACTIVITIES GENERATING THE CONFLICT BY ANOTHER MEMBER; B. DISQUALIFICATION FROM PARTICIPATION IN THE ACTIVITIES GIVING RISE TO THE CONFLICT; C. MODIFICATION OF RESPONSIBILITIES TO AVOID CONFLICTS; D. PUBLIC DISCLOSURE OR DIVESTITURE OF SIGNIFICANT FINANCIAL INTERESTS; E. MODIFICATION OF THE RESEARCH PLAN OR REMOVAL OF THE AFFECTED RESEARCHER FROM THE RESEARCH; F. SEVERANCE OF RELATIONSHIP THAT CREATES ACTUAL OR POTENTIAL CONFLICTS; G. TERMINATION OF EMPLOYMENT. LINE 15A/B:IN FISCAL YEAR 2019 (JULY 1, 2018 - JUNE 30, 2019), HUMAN RESOURCES COMPLETED A TOTAL COMPENSATION ANALYSIS FOR ALL EXECUTIVES. THE COMPENSATION COMMITTEE WAS PROVIDED MARKET DATA COMPARISON TO LIKE ROLES AMONG ORGANIZATIONS PROVIDING SIMILAR SERVICES IN THE RESEARCH INDUSTRY AND NOT-FOR-PROFIT SECTORS. HUMAN RESOURCES GAVE THE OPINION THAT THE TOTAL COMPENSATION WAS WELL WITHIN THE REASONABLE RANGE OF COMPARABLE PRACTICES AND IN LINE WITH THE GUIDELINES ARTICULATED IN THE SALK INSTITUTE EXECUTIVE COMPENSATION POLICY. A COMPENSATION COMMITTEE WAS FORMED IN 2014 TO EVALUATE EXECUTIVE COMPENSATION. THE COMMITTEE'S PURPOSE IS TO ACT ON BEHALF OF THE BOARD OF TRUSTEES TO EVALUATE THE PERFORMANCE OF THE RESIDENT/CEO; TO DETERMINE ON AN ANNUAL BASIS, APPROPRIATE COMPENSATION FOR THE PRESIDENT/CEO, VICE PRESIDENTS AND/OR EQUIVALENT PERSONS, AND TO RECOMMEND TO THE BOARD PLANS AND POLICIES PERTINENT TO THE COMPENSATION FOR THESE EXECUTIVES. THE OPINION FROM THE HUMAN RESOURCES DEPARTMENT WAS REVIEWED BY THE COMPENSATION COMMITTEE, THE EXECUTIVE COMMITTEE OF THE BOARD OF TRUSTEES, AND THE FULL BOARD OF TRUSTEES EXCLUDING THE PRESIDENT DUE TO A CONFLICT OF INTEREST WITH RESPECT TO THE COMPENSATION ARRANGEMENTS. THE DELIBERATIONS AND DECISIONS REGARDING THE COMPENSATION ACTIONS WERE INCLUDED IN THE MINUTES OF THE COMPENSATION COMMITTEE MEETING, THE EXECUTIVE COMMITTEE MEETING, AND THE FULL BOARD OF TRUSTEES MEETING. A COPY OF THE REPORT WAS ATTACHED TO THE MINUTES OF THE MEETING. DISCLOSURE FORM 990, PART VI, SECTION C, LINE 19 UPON REQUEST, THE OFFICE OF THE CHIEF FINANCIAL OFFICER MAKES AVAILABLE TO THE PUBLIC THE INSTITUTE'S GOVERNING DOCUMENTS AND CONFLICT OF INTEREST POLICY. FINANCIAL STATEMENTS ARE AVAILABLE ON THE SALK WEB SITE. OTHER CHANGES IN NET ASSETS FORM 990, PART XI, LINE 9 POSTRETIREMENT BENEFIT CHANGES OTHER THAN NET PERIODIC BENEFIT COST - $542,786; UNRELATED BUSINESS INCOME $425,157. COMPENSATION OF DIRECTORS FORM 990, PART VII, DIRECTORS COMPENSATION - THE FOLLOWING INDIVIDUALS WERE COMPENSATED FOR THE FOLLOWING SERVICES AND NOT PAID AS TRUSTEES: FRED GAGE, PH.D. - PRESIDENT/PROFESSOR; JAN KARLSEDER, PH.D. - PROFESSOR; GERALD SHADEL, PH.D. - PROFESSOR. SALK INSTITUTE COMMERCIAL SERVICES CORP 10010 N TORREY PINES ROAD LA JOLLA CA 920371002 232159172 MGMT SERVICES PA SALK INSTITUTE C 12 41112 1.00000 true CHARITABLE REMAINDER TRUSTS (5) SUPPORT CA NA TRUST false false false false false false false false false false false false true true false true false false NONE