﻿<?xml version="1.0" encoding="utf-8"?>
<Return xmlns="http://www.irs.gov/efile" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" returnVersion="2019v5.0">
  <ReturnHeader binaryAttachmentCnt="0">
    <ReturnTs>2020-07-13T11:52:44-05:00</ReturnTs>
    <TaxPeriodEndDt>2019-12-31</TaxPeriodEndDt>
    <PreparerFirmGrp>
      <PreparerFirmEIN>630857231</PreparerFirmEIN>
      <PreparerFirmName>
        <BusinessNameLine1Txt>HILL FOGG &amp; ASSOCIATES PC</BusinessNameLine1Txt>
      </PreparerFirmName>
      <PreparerUSAddress>
        <AddressLine1Txt>2420 L N DR SW STE A</AddressLine1Txt>
        <CityNm>HUNTSVILLE</CityNm>
        <StateAbbreviationCd>AL</StateAbbreviationCd>
        <ZIPCd>35801</ZIPCd>
      </PreparerUSAddress>
    </PreparerFirmGrp>
    <ReturnTypeCd>990EZ</ReturnTypeCd>
    <TaxPeriodBeginDt>2019-01-01</TaxPeriodBeginDt>
    <Filer>
      <EIN>464279769</EIN>
      <BusinessName>
        <BusinessNameLine1Txt>PTEN HAMARATOMA SYNDROME FOUNDATION</BusinessNameLine1Txt>
      </BusinessName>
      <BusinessNameControlTxt>PTEN</BusinessNameControlTxt>
      <PhoneNum>2565335850</PhoneNum>
      <USAddress>
        <AddressLine1Txt>2325 LITTLE COVE ROAD</AddressLine1Txt>
        <CityNm>HAMPTON COVE</CityNm>
        <StateAbbreviationCd>AL</StateAbbreviationCd>
        <ZIPCd>35763</ZIPCd>
      </USAddress>
    </Filer>
    <BusinessOfficerGrp>
      <PersonNm>KRISTIN ANTHONY</PersonNm>
      <PersonTitleTxt>PRESIDENT</PersonTitleTxt>
      <PhoneNum>2565335850</PhoneNum>
      <SignatureDt>2020-06-25</SignatureDt>
    </BusinessOfficerGrp>
    <PreparerPersonGrp>
      <PreparerPersonNm>JASON M ANGELICHIO CPA</PreparerPersonNm>
      <PTIN>P00745462</PTIN>
      <PhoneNum>2565394413</PhoneNum>
      <PreparationDt>2020-07-06</PreparationDt>
    </PreparerPersonGrp>
    <FilingSecurityInformation>
      <IPAddress>
        <IPv4AddressTxt>50.236.34.114</IPv4AddressTxt>
      </IPAddress>
      <IPDt>2020-07-13</IPDt>
      <IPTm>11:52:44</IPTm>
      <IPTimezoneCd>CD</IPTimezoneCd>
      <FilingLicenseTypeCd>P</FilingLicenseTypeCd>
      <AtSubmissionCreationDeviceId>7C847FCECACB77F5C607AD4AEDFCA7E0D862EF91</AtSubmissionCreationDeviceId>
      <AtSubmissionFilingDeviceId>2CE8E7887BABF78BB5BE6782E1E2C709882EF811</AtSubmissionFilingDeviceId>
    </FilingSecurityInformation>
    <TaxYr>2019</TaxYr>
    <BuildTS>2020-09-23 17:36:50Z</BuildTS>
  </ReturnHeader>
  <ReturnData documentCnt="3">
    <IRS990EZ documentId="RetDoc2" referenceDocumentId="RetDoc3">
      <MethodOfAccountingAccrualInd>X</MethodOfAccountingAccrualInd>
      <ScheduleBNotRequiredInd>X</ScheduleBNotRequiredInd>
      <WebsiteAddressTxt>WWW.PTENFOUNDATION.ORG</WebsiteAddressTxt>
      <Organization501c3Ind referenceDocumentId="RetDoc4">X</Organization501c3Ind>
      <TypeOfOrganizationCorpInd>X</TypeOfOrganizationCorpInd>
      <GrossReceiptsAmt>53075</GrossReceiptsAmt>
      <InfoInScheduleOPartIInd>X</InfoInScheduleOPartIInd>
      <ContributionsGiftsGrantsEtcAmt>52625</ContributionsGiftsGrantsEtcAmt>
      <InvestmentIncomeAmt>450</InvestmentIncomeAmt>
      <TotalRevenueAmt>53075</TotalRevenueAmt>
      <SalariesOtherCompEmplBnftAmt>13882</SalariesOtherCompEmplBnftAmt>
      <OccupancyRentUtltsAndMaintAmt>663</OccupancyRentUtltsAndMaintAmt>
      <PrintingPublicationsPostageAmt>3086</PrintingPublicationsPostageAmt>
      <OtherExpensesTotalAmt>40516</OtherExpensesTotalAmt>
      <TotalExpensesAmt>58147</TotalExpensesAmt>
      <ExcessOrDeficitForYearAmt>-5072</ExcessOrDeficitForYearAmt>
      <NetAssetsOrFundBalancesBOYAmt>64043</NetAssetsOrFundBalancesBOYAmt>
      <OtherChangesInNetAssetsAmt>461</OtherChangesInNetAssetsAmt>
      <NetAssetsOrFundBalancesEOYAmt>59432</NetAssetsOrFundBalancesEOYAmt>
      <InfoInScheduleOPartIIInd>X</InfoInScheduleOPartIIInd>
      <CashSavingsAndInvestmentsGrp>
        <BOYAmt>55934</BOYAmt>
        <EOYAmt>46786</EOYAmt>
      </CashSavingsAndInvestmentsGrp>
      <OtherAssetsTotalDetail>
        <BOYAmt>12847</BOYAmt>
        <EOYAmt>12646</EOYAmt>
      </OtherAssetsTotalDetail>
      <Form990TotalAssetsGrp>
        <BOYAmt>68781</BOYAmt>
        <EOYAmt>59432</EOYAmt>
      </Form990TotalAssetsGrp>
      <SumOfTotalLiabilitiesGrp>
        <BOYAmt>4738</BOYAmt>
      </SumOfTotalLiabilitiesGrp>
      <NetAssetsOrFundBalancesGrp>
        <BOYAmt>64043</BOYAmt>
        <EOYAmt>59432</EOYAmt>
      </NetAssetsOrFundBalancesGrp>
      <InfoInScheduleOPartIIIInd>X</InfoInScheduleOPartIIIInd>
      <PrimaryExemptPurposeTxt>TO FIND TREATMENTS OR THERAPIES FOR PTEN SYNDROMES BY FUNDING RESEARCH, PROVIDING PHTS EDUCATION, SUPPORTING PATIENTS, AND BY RAISING AWARENESS.</PrimaryExemptPurposeTxt>
      <ProgramSrvcAccomplishmentGrp>
        <DescriptionProgramSrvcAccomTxt>INCREASE AWARENESS OF PTEN HARARTOMA TUMOR SYNDROME, INCLUDING COWDEN SYNDROME, BANNAYAN-RILEY-RUVALCABA SYNDROME, PTEN-RELATED PROTEUS SYNDROME, AND PROTEUS-LIKE SYNDROME</DescriptionProgramSrvcAccomTxt>
        <ProgramServiceExpensesAmt>31399</ProgramServiceExpensesAmt>
      </ProgramSrvcAccomplishmentGrp>
      <ProgramSrvcAccomplishmentGrp>
        <DescriptionProgramSrvcAccomTxt>FUND RESEARCH OF PTEN HAMARTOMA TUMOR SYNDROMES BY PROVIDING GRANTS TO ASSOCIATED RESEARCH CENTERS AMD ORGANIZATIONS</DescriptionProgramSrvcAccomTxt>
        <ProgramServiceExpensesAmt>581</ProgramServiceExpensesAmt>
      </ProgramSrvcAccomplishmentGrp>
      <ProgramSrvcAccomplishmentGrp>
        <DescriptionProgramSrvcAccomTxt>PROVIDE SCHOLARDSHIPS FOR PATIENTS OF PTEN HAMARTOMA TUMOR SYNDROMES</DescriptionProgramSrvcAccomTxt>
        <ProgramServiceExpensesAmt>26167</ProgramServiceExpensesAmt>
      </ProgramSrvcAccomplishmentGrp>
      <TotalProgramServiceExpensesAmt>58147</TotalProgramServiceExpensesAmt>
      <OfficerDirectorTrusteeEmplGrp>
        <PersonNm>KRISTIN ANTHONY</PersonNm>
        <TitleTxt>PRESIDENT</TitleTxt>
        <AverageHrsPerWkDevotedToPosRt>50.00</AverageHrsPerWkDevotedToPosRt>
        <CompensationAmt>12646</CompensationAmt>
      </OfficerDirectorTrusteeEmplGrp>
      <OfficerDirectorTrusteeEmplGrp>
        <PersonNm>STEPHEN E PAZIAN SR</PersonNm>
        <TitleTxt>VICE PRESIDE</TitleTxt>
        <AverageHrsPerWkDevotedToPosRt>000.00</AverageHrsPerWkDevotedToPosRt>
        <CompensationAmt>0</CompensationAmt>
      </OfficerDirectorTrusteeEmplGrp>
      <OfficerDirectorTrusteeEmplGrp>
        <PersonNm>STAN ANTHONY</PersonNm>
        <TitleTxt>TREASURER</TitleTxt>
        <AverageHrsPerWkDevotedToPosRt>000.00</AverageHrsPerWkDevotedToPosRt>
        <CompensationAmt>0</CompensationAmt>
      </OfficerDirectorTrusteeEmplGrp>
      <ActivitiesNotPreviouslyRptInd>false</ActivitiesNotPreviouslyRptInd>
      <ChgMadeToOrgnzngDocNotRptInd>false</ChgMadeToOrgnzngDocNotRptInd>
      <OrganizationHadUBIInd>false</OrganizationHadUBIInd>
      <SubjectToProxyTaxInd>false</SubjectToProxyTaxInd>
      <OrganizationDissolvedEtcInd>false</OrganizationDissolvedEtcInd>
      <Form1120PolFiledInd>false</Form1120PolFiledInd>
      <MadeLoansToFromOfficersInd>false</MadeLoansToFromOfficersInd>
      <EngagedInExcessBenefitTransInd>false</EngagedInExcessBenefitTransInd>
      <ProhibitedTaxShelterTransInd>false</ProhibitedTaxShelterTransInd>
      <BooksInCareOfDetail>
        <PersonNm>KRISTIN ANTHONY</PersonNm>
        <USAddress>
          <AddressLine1Txt>2325 LITTLE COVE ROAD</AddressLine1Txt>
          <CityNm>HAMPTON COVE</CityNm>
          <StateAbbreviationCd>AL</StateAbbreviationCd>
          <ZIPCd>35763</ZIPCd>
        </USAddress>
        <PhoneNum>2565335850</PhoneNum>
      </BooksInCareOfDetail>
      <ForeignFinancialAccountInd>false</ForeignFinancialAccountInd>
      <ForeignOfficeInd>false</ForeignOfficeInd>
      <DonorAdvisedFndsInd>false</DonorAdvisedFndsInd>
      <OperateHospitalInd>false</OperateHospitalInd>
      <TanningServicesProvidedInd>false</TanningServicesProvidedInd>
      <RelatedOrganizationCtrlEntInd>false</RelatedOrganizationCtrlEntInd>
      <TransactionWithControlEntInd>false</TransactionWithControlEntInd>
      <PoliticalCampaignActyInd>false</PoliticalCampaignActyInd>
      <LobbyingActivitiesInd>false</LobbyingActivitiesInd>
      <SchoolOperatingInd>false</SchoolOperatingInd>
      <TrnsfrExmptNonChrtblRltdOrgInd>false</TrnsfrExmptNonChrtblRltdOrgInd>
      <PartVIOfCompOfHghstPdEmplTxt>NONE</PartVIOfCompOfHghstPdEmplTxt>
      <PartVIHghstPdCntrctProfSrvcTxt>NONE</PartVIHghstPdCntrctProfSrvcTxt>
      <FiledScheduleAInd>true</FiledScheduleAInd>
    </IRS990EZ>
    <IRS990ScheduleA documentId="RetDoc4">
      <PublicOrganization170Ind>X</PublicOrganization170Ind>
      <GiftsGrantsContriRcvd170Grp>
        <CurrentTaxYearMinus4YearsAmt>9043</CurrentTaxYearMinus4YearsAmt>
        <CurrentTaxYearMinus3YearsAmt>16992</CurrentTaxYearMinus3YearsAmt>
        <CurrentTaxYearMinus2YearsAmt>77321</CurrentTaxYearMinus2YearsAmt>
        <CurrentTaxYearMinus1YearAmt>75331</CurrentTaxYearMinus1YearAmt>
        <CurrentTaxYearAmt>46787</CurrentTaxYearAmt>
        <TotalAmt>225474</TotalAmt>
      </GiftsGrantsContriRcvd170Grp>
      <TotalCalendarYear170Grp>
        <CurrentTaxYearMinus4YearsAmt>9043</CurrentTaxYearMinus4YearsAmt>
        <CurrentTaxYearMinus3YearsAmt>16992</CurrentTaxYearMinus3YearsAmt>
        <CurrentTaxYearMinus2YearsAmt>77321</CurrentTaxYearMinus2YearsAmt>
        <CurrentTaxYearMinus1YearAmt>75331</CurrentTaxYearMinus1YearAmt>
        <CurrentTaxYearAmt>46787</CurrentTaxYearAmt>
        <TotalAmt>225474</TotalAmt>
      </TotalCalendarYear170Grp>
      <PublicSupportTotal170Amt>225474</PublicSupportTotal170Amt>
      <GrossInvestmentIncome170Grp>
        <CurrentTaxYearMinus4YearsAmt>5</CurrentTaxYearMinus4YearsAmt>
        <CurrentTaxYearMinus3YearsAmt>19</CurrentTaxYearMinus3YearsAmt>
        <CurrentTaxYearMinus2YearsAmt>67</CurrentTaxYearMinus2YearsAmt>
        <CurrentTaxYearMinus1YearAmt>307</CurrentTaxYearMinus1YearAmt>
        <CurrentTaxYearAmt>450</CurrentTaxYearAmt>
        <TotalAmt>848</TotalAmt>
      </GrossInvestmentIncome170Grp>
      <TotalSupportAmt>226322</TotalSupportAmt>
      <GrossReceiptsRltdActivitiesAmt>450</GrossReceiptsRltdActivitiesAmt>
      <PublicSupportCY170Pct>0.99630</PublicSupportCY170Pct>
      <PublicSupportPY170Pct>0.99950</PublicSupportPY170Pct>
      <ThirtyThrPctSuprtTestsCY170Ind>X</ThirtyThrPctSuprtTestsCY170Ind>
    </IRS990ScheduleA>
    <IRS990ScheduleO documentId="RetDoc3">
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990-EZ, PART I, LINE 16</FormAndLineReferenceDesc>
        <ExplanationTxt>EXPENSES ADVERTISING AND PROMOTION 2,938 OFFICE 2,747 INFORMATION TECHNOLOGY 2,748 TRAVEL 8,176 CONFERENCES/MEETINGS 1,351 INSURANCE 1,426 DUES AND SUBSCRIPTIONS 2,867 FEES ANC CHARGES 124 MEALS AND ENTERTAINMENT 1,809 MISCELLANEOUS 45 PROFESSIONAL FEES 2,905 RESOURCES AND PUBLICATION 40 SUPPLIES 10 TELEPHONE EXPENSE 23 SCHOLARSHIP EXPENSES 3,050 REGISTRY EXPENSES 10,257 TOTAL 40,516</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990-EZ, PART I, LINE 20</FormAndLineReferenceDesc>
        <ExplanationTxt>BOOK / TAX DEPRECIATION DIFFERENCE 461</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990-EZ, PART II, LINE 24</FormAndLineReferenceDesc>
        <ExplanationTxt>FURNITURE &amp; EQUIPMENT 3,302 3,302 LESS ACCUMULATED DEPRECIATION 294 440 PUBLIC RELATIONS 9,950 9,950 LESS ACCUMULATED AMORTIZATION 111 166 TOTAL 12,847 12,646</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990-EZ, PART II, LINE 26</FormAndLineReferenceDesc>
        <ExplanationTxt>PAYROLL TAX LIABILITIES 4,738 0</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990-EZ, PART III</FormAndLineReferenceDesc>
        <ExplanationTxt>TO FIND TREATMENTS OR THERAPIES FOR PTEN SYNDROMES BY FUNDING RESEARCH, PROVIDING PHTS EDUCATION, SUPPORTING PATIENTS, AND BY RAISING AWARENESS.</ExplanationTxt>
      </SupplementalInformationDetail>
    </IRS990ScheduleO>
  </ReturnData>
</Return>