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      <Form990PartVIISectionAGrp>
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        <PersonNm>Anita Bekenstein</PersonNm>
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      <Form990PartVIISectionAGrp>
        <PersonNm>Sarah Brown</PersonNm>
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        <PersonNm>Paul Gannon</PersonNm>
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        <PersonNm>Howard H Stevenson</PersonNm>
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      <ContractorCompensationGrp>
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      <ContractorCompensationGrp>
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      <ContractorCompensationGrp>
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          <BusinessName>
            <BusinessNameLine1Txt>Research Triangle Institute</BusinessNameLine1Txt>
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      <OtherExpensesGrp>
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          <ZIPCd>98118</ZIPCd>
        </USAddress>
        <RecipientEIN>473348689</RecipientEIN>
        <IRCSectionDesc>501(c)(3)</IRCSectionDesc>
        <CashGrantAmt>33563</CashGrantAmt>
        <NonCashAssistanceAmt>0</NonCashAssistanceAmt>
        <ValuationMethodUsedDesc>Cash</ValuationMethodUsedDesc>
        <PurposeOfGrantTxt>Reproductive Health Program Training</PurposeOfGrantTxt>
      </RecipientTable>
      <RecipientTable>
        <RecipientBusinessName>
          <BusinessNameLine1Txt>Westside Family Healthcare Inc</BusinessNameLine1Txt>
        </RecipientBusinessName>
        <USAddress>
          <AddressLine1Txt>300 Water Street</AddressLine1Txt>
          <AddressLine2Txt>Suite 200</AddressLine2Txt>
          <CityNm>Wilmington</CityNm>
          <StateAbbreviationCd>DE</StateAbbreviationCd>
          <ZIPCd>19801</ZIPCd>
        </USAddress>
        <RecipientEIN>222488654</RecipientEIN>
        <IRCSectionDesc>501(c)(3)</IRCSectionDesc>
        <CashGrantAmt>10000</CashGrantAmt>
        <NonCashAssistanceAmt>0</NonCashAssistanceAmt>
        <ValuationMethodUsedDesc>Cash</ValuationMethodUsedDesc>
        <PurposeOfGrantTxt>Reproductive Health Program Training</PurposeOfGrantTxt>
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      <Total501c3OrgCnt>14</Total501c3OrgCnt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Schedule I, Part I, Line 2</FormAndLineReferenceDesc>
        <ExplanationTxt>Upstream works in partnership with organizations receiving grants to determine program milestones that will initiate grant payments once they are met. These milestones are documented and agreed to in a memorandum of understanding between Upstream and the organization receiving the grant. When a milestone is reached, Upstream reviews and verifies supporting documentation, such as a training roster or evidence of an organization's expenditure, before issuing the grant payment.</ExplanationTxt>
      </SupplementalInformationDetail>
    </IRS990ScheduleI>
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      <IndependentConsultantInd>X</IndependentConsultantInd>
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      <RltdOrgOfficerTrstKeyEmplGrp>
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        <FormAndLineReferenceDesc>Schedule J, Part I, Line 4</FormAndLineReferenceDesc>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Schedule J, Part I, Line 7</FormAndLineReferenceDesc>
        <ExplanationTxt>Upstream provides a referral bonus to any employee who referred a candidate that was hired by Upstream. Any such bonuses are reviewed and approved by organizational leadership. The CEO received a discretionary bonus payment in recognition of high performance and outstanding work. This was determined and authorized by the Board's Compensation Committee and the independent members of the Upstream Board of Directors. Refer to Schedule O for additional information regarding the determination of compensation.</ExplanationTxt>
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      <SupplementalInformationDetail>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI, Section B, Line 11b</FormAndLineReferenceDesc>
        <ExplanationTxt>The Form 990 is prepared by the Upstream accounting team and then reviewed closely by AAFCPAs, Upstream's tax advisor, and Upstream's Chief of Finance &amp; Administration Officer. This draft is then provided to the Audit Committee for their review and approval. Finally, the Form 990 is provided to the full Board of Directors prior to filing. Any and all questions and comments are addressed by the Upstream Chief Finance &amp; Administration Officer who engages AAFCPAs in the discussion whenever relevant or necessary.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI, Section B, Line 12c</FormAndLineReferenceDesc>
        <ExplanationTxt>The Board authorized and oversees an annual review of the administration of Upstream's conflict of interest policy. The review may be written or oral. The review shall consider the level of compliance with the policy, the continuing suitability of the policy, and whether the policy should be modified and improved. The process occurs each year during a scheduled meeting of the Upstream Board.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI, Section B, Line 15</FormAndLineReferenceDesc>
        <ExplanationTxt>The Compensation Committee of the Board of Directors, none of whose members have a conflict of interest, is charged with recommending the compensation of Upstream's CEO and CFAO to the Board of Directors on an annual basis. Comparability data for similarly qualified persons in functionally comparable positions at similarly situated organizations is prepared by a compensation consultant on a regular basis. This data was last compiled to set 2020 compensation rates and will next be compiled in Fall 2021. The CEO's 360 performance evaluations, the CFAO's performance evaluation, and the comparability data, in years which it is compiled, are reviewed by the Compensation Committee before forming recommendations around changes in compensation to the Board of Directors. The Board of Directors reviews the Committee's recommendation and votes on it. The CEO, who is also a member of the Board of Directors, is recused from this review and vote. These deliberations and decisions are documented in the minutes contemporaneously. This recommendation, review, and vote occur every year and were last completed in 2020.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI, Section C, Line 19</FormAndLineReferenceDesc>
        <ExplanationTxt>Upstream's governing documents, conflict of interest policy, and financial statements are available to the public upon request.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part XII, Line 2c</FormAndLineReferenceDesc>
        <ExplanationTxt>The process has not changed from the prior year.</ExplanationTxt>
      </SupplementalInformationDetail>
    </IRS990ScheduleO>
  </ReturnData>
</Return>