<?xml version="1.0" encoding="utf-8"?>
<Return xmlns="http://www.irs.gov/efile" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" returnVersion="2020v4.0">
  <ReturnHeader binaryAttachmentCnt="0">
    <ReturnTs>2021-11-02T16:43:59-05:00</ReturnTs>
    <TaxPeriodEndDt>2020-12-31</TaxPeriodEndDt>
    <PreparerFirmGrp>
      <PreparerFirmEIN>631262841</PreparerFirmEIN>
      <PreparerFirmName>
        <BusinessNameLine1Txt>ANGLIN REICHMANN ARMSTRONG PC</BusinessNameLine1Txt>
      </PreparerFirmName>
      <PreparerUSAddress>
        <AddressLine1Txt>305 QUALITY CIRCLE</AddressLine1Txt>
        <CityNm>HUNTSVILLE</CityNm>
        <StateAbbreviationCd>AL</StateAbbreviationCd>
        <ZIPCd>358065539</ZIPCd>
      </PreparerUSAddress>
    </PreparerFirmGrp>
    <ReturnTypeCd>990</ReturnTypeCd>
    <TaxPeriodBeginDt>2020-01-01</TaxPeriodBeginDt>
    <Filer>
      <EIN>432059317</EIN>
      <BusinessName>
        <BusinessNameLine1Txt>HUDSON-ALPHA INSTITUTE FOR</BusinessNameLine1Txt>
        <BusinessNameLine2Txt>BIOTECHNOLOGY</BusinessNameLine2Txt>
      </BusinessName>
      <BusinessNameControlTxt>HUDS</BusinessNameControlTxt>
      <PhoneNum>2563270400</PhoneNum>
      <USAddress>
        <AddressLine1Txt>601 GENOME WAY</AddressLine1Txt>
        <CityNm>HUNTSVILLE</CityNm>
        <StateAbbreviationCd>AL</StateAbbreviationCd>
        <ZIPCd>35806</ZIPCd>
      </USAddress>
    </Filer>
    <BusinessOfficerGrp>
      <PersonNm>PETER YANUL</PersonNm>
      <PersonTitleTxt>CFO</PersonTitleTxt>
      <PhoneNum>2563270400</PhoneNum>
      <SignatureDt>2021-10-29</SignatureDt>
      <DiscussWithPaidPreparerInd>true</DiscussWithPaidPreparerInd>
    </BusinessOfficerGrp>
    <SigningOfficerGrp>
      <PersonFullName>
        <PersonFirstNm>PETER</PersonFirstNm>
        <PersonLastNm>YANUL</PersonLastNm>
      </PersonFullName>
      <SSN>999009999</SSN>
    </SigningOfficerGrp>
    <PreparerPersonGrp>
      <PreparerPersonNm>TRACY L SAMS CPA</PreparerPersonNm>
      <PTIN>P00637535</PTIN>
      <PhoneNum>2565331040</PhoneNum>
      <PreparationDt>2021-10-29</PreparationDt>
    </PreparerPersonGrp>
    <TaxYr>2020</TaxYr>
    <BuildTS>2022-09-23 18:48:47Z</BuildTS>
  </ReturnHeader>
  <ReturnData documentCnt="9">
    <IRS990 documentId="RetDoc2" referenceDocumentId="RetDoc7">
      <PrincipalOfficerNm>RICHARD MYERS</PrincipalOfficerNm>
      <USAddress>
        <AddressLine1Txt>601 GENOME WAY</AddressLine1Txt>
        <CityNm>HUNTSVILLE</CityNm>
        <StateAbbreviationCd>AL</StateAbbreviationCd>
        <ZIPCd>35806</ZIPCd>
      </USAddress>
      <GrossReceiptsAmt>52808187</GrossReceiptsAmt>
      <GroupReturnForAffiliatesInd>false</GroupReturnForAffiliatesInd>
      <Organization501c3Ind>X</Organization501c3Ind>
      <WebsiteAddressTxt>WWW.HUDSONALPHA.ORG</WebsiteAddressTxt>
      <TypeOfOrganizationCorpInd>X</TypeOfOrganizationCorpInd>
      <FormationYr>2004</FormationYr>
      <LegalDomicileStateCd>AL</LegalDomicileStateCd>
      <ActivityOrMissionDesc>THE PRIMARY MISSION OF THE INSTITUTE WILL BE TO USE THE INCREASINGLY POWERFUL RESEARCH TOOLS BEING DEVELOPED IN THE BIOTECHNOLOGY AREA TO BETTER UNDERSTAND THE CAUSES OF CERTAIN DISEASES AND TO APPLY THE FINDINGS OF SUCH RESEARCH TO HELP DEVELOP NEW AND MORE EFFECTIVE TREATMENTS FOR SUCH DISEASES. THE INSTITUTE'S CHARITABLE MISSION CONTEMPLATES NUMEROUS OTHER ACTIVITIES ALL OF WHICH ARE INTENDED TO HELP FURTHER BIOTECH RESEARCH IN ALABAMA.</ActivityOrMissionDesc>
      <VotingMembersGoverningBodyCnt>11</VotingMembersGoverningBodyCnt>
      <VotingMembersIndependentCnt>11</VotingMembersIndependentCnt>
      <TotalEmployeeCnt>223</TotalEmployeeCnt>
      <TotalGrossUBIAmt>-10146063</TotalGrossUBIAmt>
      <PYContributionsGrantsAmt>31595656</PYContributionsGrantsAmt>
      <CYContributionsGrantsAmt>54506794</CYContributionsGrantsAmt>
      <PYProgramServiceRevenueAmt>15635804</PYProgramServiceRevenueAmt>
      <CYProgramServiceRevenueAmt>2320338</CYProgramServiceRevenueAmt>
      <PYInvestmentIncomeAmt>90944758</PYInvestmentIncomeAmt>
      <CYInvestmentIncomeAmt>496107</CYInvestmentIncomeAmt>
      <PYOtherRevenueAmt>1442803</PYOtherRevenueAmt>
      <CYOtherRevenueAmt>-5517802</CYOtherRevenueAmt>
      <PYTotalRevenueAmt>139619021</PYTotalRevenueAmt>
      <CYTotalRevenueAmt>51805437</CYTotalRevenueAmt>
      <CYGrantsAndSimilarPaidAmt>0</CYGrantsAndSimilarPaidAmt>
      <CYBenefitsPaidToMembersAmt>0</CYBenefitsPaidToMembersAmt>
      <PYSalariesCompEmpBnftPaidAmt>12008713</PYSalariesCompEmpBnftPaidAmt>
      <CYSalariesCompEmpBnftPaidAmt>12995814</CYSalariesCompEmpBnftPaidAmt>
      <PYTotalProfFndrsngExpnsAmt>93287</PYTotalProfFndrsngExpnsAmt>
      <CYTotalProfFndrsngExpnsAmt>57667</CYTotalProfFndrsngExpnsAmt>
      <CYTotalFundraisingExpenseAmt>613056</CYTotalFundraisingExpenseAmt>
      <PYOtherExpensesAmt>46934723</PYOtherExpensesAmt>
      <CYOtherExpensesAmt>44526141</CYOtherExpensesAmt>
      <PYTotalExpensesAmt>59036723</PYTotalExpensesAmt>
      <CYTotalExpensesAmt>57579622</CYTotalExpensesAmt>
      <PYRevenuesLessExpensesAmt>80582298</PYRevenuesLessExpensesAmt>
      <CYRevenuesLessExpensesAmt>-5774185</CYRevenuesLessExpensesAmt>
      <TotalAssetsBOYAmt>194073537</TotalAssetsBOYAmt>
      <TotalAssetsEOYAmt>211512056</TotalAssetsEOYAmt>
      <TotalLiabilitiesBOYAmt>7359552</TotalLiabilitiesBOYAmt>
      <TotalLiabilitiesEOYAmt>20270749</TotalLiabilitiesEOYAmt>
      <NetAssetsOrFundBalancesBOYAmt>186713985</NetAssetsOrFundBalancesBOYAmt>
      <NetAssetsOrFundBalancesEOYAmt>191241307</NetAssetsOrFundBalancesEOYAmt>
      <InfoInScheduleOPartIIIInd>X</InfoInScheduleOPartIIIInd>
      <MissionDesc>THE PRIMARY MISSION OF THE INSTITUTE WILL BE TO USE THE INCREASINGLY POWERFUL RESEARCH TOOLS BEING DEVELOPED IN THE BIOTECHNOLOGY AREA TO BETTER UNDERSTAND THE CAUSES OF CERTAIN DISEASES AND TO APPLY THE FINDINGS OF SUCH RESEARCH TO HELP DEVELOP NEW AND MORE EFFECTIVE TREATMENTS FOR SUCH DISEASES. THE INSTITUTE'S CHARITABLE MISSION CONTEMPLATES NUMEROUS OTHER ACTIVITIES ALL OF WHICH ARE INTENDED TO HELP FURTHER BIOTECH RESEARCH IN ALABAMA.</MissionDesc>
      <SignificantNewProgramSrvcInd>false</SignificantNewProgramSrvcInd>
      <SignificantChangeInd>false</SignificantChangeInd>
      <ExpenseAmt>27449359</ExpenseAmt>
      <Desc>ACTIVITIES, PROGRAMS, AND COLLABORATIONS FOR THE INSTITUTE TO ACCOMPLISH ITS CHARITABLE OBJECTIVE OF SERVING AS A CATALYST FOR BIOTECHNOLOGY RESEARCH AND DEVELOPEMENT.</Desc>
      <ProgSrvcAccomActy2Grp>
        <ExpenseAmt>2945154</ExpenseAmt>
        <Desc>ACTIVITIES, PROGRAMS AND COLLABORATIONS FOR THE INSTITUTE TO ACCOMPLISH ITS CHARITABLE OBJECTIVE OF PROVIDING A VARIETY OF EDUCATIONAL OUTREACH PROGRAMS.</Desc>
      </ProgSrvcAccomActy2Grp>
      <ProgSrvcAccomActy3Grp>
        <ExpenseAmt>4318354</ExpenseAmt>
        <Desc>ACTIVITIES, PROGRAMS AND COLLABORATIONS FOR THE INSTITUTE TO ACCOMPLISH ITS CHARITABLE OBJECTIVE OF DEVELOPING, PROVIDING AND ADVANCING GENOMIC MEDICINE PROGRAMS.</Desc>
      </ProgSrvcAccomActy3Grp>
      <ProgSrvcAccomActyOtherGrp>
        <ExpenseAmt>6521477</ExpenseAmt>
        <Desc>ACTIVITIES, PROGRAMS AND COLLABORATIONS FOR THE INSTITUE TO ACCOMPLISH ITS CHARITABLE OBJECTIVE OF CREATING ECONOMIC GROWTH IN BIOTECHNOLOGY RELATED FIELDS</Desc>
      </ProgSrvcAccomActyOtherGrp>
      <TotalOtherProgSrvcExpenseAmt>6521477</TotalOtherProgSrvcExpenseAmt>
      <TotalProgramServiceExpensesAmt>41234344</TotalProgramServiceExpensesAmt>
      <DescribedInSection501c3Ind referenceDocumentId="RetDoc9">true</DescribedInSection501c3Ind>
      <ScheduleBRequiredInd referenceDocumentId="RetDoc1">true</ScheduleBRequiredInd>
      <PoliticalCampaignActyInd referenceDocumentId="RetDoc3">false</PoliticalCampaignActyInd>
      <LobbyingActivitiesInd referenceDocumentId="RetDoc3">true</LobbyingActivitiesInd>
      <SubjectToProxyTaxInd referenceDocumentId="RetDoc3">false</SubjectToProxyTaxInd>
      <DonorAdvisedFundInd referenceDocumentId="RetDoc4">false</DonorAdvisedFundInd>
      <ConservationEasementsInd referenceDocumentId="RetDoc4">false</ConservationEasementsInd>
      <CollectionsOfArtInd referenceDocumentId="RetDoc4">false</CollectionsOfArtInd>
      <CreditCounselingInd referenceDocumentId="RetDoc4">false</CreditCounselingInd>
      <DonorRstrOrQuasiEndowmentsInd referenceDocumentId="RetDoc4">true</DonorRstrOrQuasiEndowmentsInd>
      <ReportLandBuildingEquipmentInd referenceDocumentId="RetDoc4">true</ReportLandBuildingEquipmentInd>
      <ReportInvestmentsOtherSecInd referenceDocumentId="RetDoc4">true</ReportInvestmentsOtherSecInd>
      <ReportProgramRelatedInvstInd referenceDocumentId="RetDoc4">false</ReportProgramRelatedInvstInd>
      <ReportOtherAssetsInd referenceDocumentId="RetDoc4">false</ReportOtherAssetsInd>
      <ReportOtherLiabilitiesInd referenceDocumentId="RetDoc4">true</ReportOtherLiabilitiesInd>
      <IncludeFIN48FootnoteInd referenceDocumentId="RetDoc4">false</IncludeFIN48FootnoteInd>
      <IndependentAuditFinclStmtInd referenceDocumentId="RetDoc4">false</IndependentAuditFinclStmtInd>
      <ConsolidatedAuditFinclStmtInd referenceDocumentId="RetDoc4">true</ConsolidatedAuditFinclStmtInd>
      <SchoolOperatingInd>false</SchoolOperatingInd>
      <ForeignOfficeInd>true</ForeignOfficeInd>
      <ForeignActivitiesInd>false</ForeignActivitiesInd>
      <MoreThan5000KToOrgInd>false</MoreThan5000KToOrgInd>
      <MoreThan5000KToIndividualsInd>false</MoreThan5000KToIndividualsInd>
      <ProfessionalFundraisingInd referenceDocumentId="RetDoc5">true</ProfessionalFundraisingInd>
      <FundraisingActivitiesInd referenceDocumentId="RetDoc5">false</FundraisingActivitiesInd>
      <GamingActivitiesInd referenceDocumentId="RetDoc5">false</GamingActivitiesInd>
      <OperateHospitalInd>false</OperateHospitalInd>
      <GrantsToOrganizationsInd>false</GrantsToOrganizationsInd>
      <GrantsToIndividualsInd>false</GrantsToIndividualsInd>
      <ScheduleJRequiredInd referenceDocumentId="RetDoc6">true</ScheduleJRequiredInd>
      <TaxExemptBondsInd>false</TaxExemptBondsInd>
      <EngagedInExcessBenefitTransInd>false</EngagedInExcessBenefitTransInd>
      <PYExcessBenefitTransInd>false</PYExcessBenefitTransInd>
      <LoanOutstandingInd>false</LoanOutstandingInd>
      <GrantToRelatedPersonInd>false</GrantToRelatedPersonInd>
      <BusinessRlnWithOrgMemInd>false</BusinessRlnWithOrgMemInd>
      <BusinessRlnWithFamMemInd>false</BusinessRlnWithFamMemInd>
      <BusinessRlnWith35CtrlEntInd>false</BusinessRlnWith35CtrlEntInd>
      <DeductibleNonCashContriInd>false</DeductibleNonCashContriInd>
      <DeductibleArtContributionInd>false</DeductibleArtContributionInd>
      <TerminateOperationsInd>false</TerminateOperationsInd>
      <PartialLiquidationInd>false</PartialLiquidationInd>
      <DisregardedEntityInd referenceDocumentId="RetDoc8">true</DisregardedEntityInd>
      <RelatedEntityInd referenceDocumentId="RetDoc8">true</RelatedEntityInd>
      <RelatedOrganizationCtrlEntInd>false</RelatedOrganizationCtrlEntInd>
      <TrnsfrExmptNonChrtblRltdOrgInd referenceDocumentId="RetDoc8">false</TrnsfrExmptNonChrtblRltdOrgInd>
      <ActivitiesConductedPrtshpInd referenceDocumentId="RetDoc8">false</ActivitiesConductedPrtshpInd>
      <ScheduleORequiredInd>true</ScheduleORequiredInd>
      <IRPDocumentCnt>129</IRPDocumentCnt>
      <IRPDocumentW2GCnt>0</IRPDocumentW2GCnt>
      <BackupWthldComplianceInd>true</BackupWthldComplianceInd>
      <EmployeeCnt>223</EmployeeCnt>
      <EmploymentTaxReturnsFiledInd>true</EmploymentTaxReturnsFiledInd>
      <UnrelatedBusIncmOverLimitInd>false</UnrelatedBusIncmOverLimitInd>
      <ForeignFinancialAccountInd>false</ForeignFinancialAccountInd>
      <ProhibitedTaxShelterTransInd>false</ProhibitedTaxShelterTransInd>
      <TaxablePartyNotificationInd>false</TaxablePartyNotificationInd>
      <NondeductibleContributionsInd>false</NondeductibleContributionsInd>
      <IndoorTanningServicesInd>false</IndoorTanningServicesInd>
      <SubjToTaxRmnrtnExPrchtPymtInd>false</SubjToTaxRmnrtnExPrchtPymtInd>
      <SubjectToExcsTaxNetInvstIncInd>false</SubjectToExcsTaxNetInvstIncInd>
      <InfoInScheduleOPartVIInd>X</InfoInScheduleOPartVIInd>
      <GoverningBodyVotingMembersCnt>11</GoverningBodyVotingMembersCnt>
      <IndependentVotingMemberCnt>11</IndependentVotingMemberCnt>
      <FamilyOrBusinessRlnInd>false</FamilyOrBusinessRlnInd>
      <DelegationOfMgmtDutiesInd>false</DelegationOfMgmtDutiesInd>
      <ChangeToOrgDocumentsInd>false</ChangeToOrgDocumentsInd>
      <MaterialDiversionOrMisuseInd>false</MaterialDiversionOrMisuseInd>
      <MembersOrStockholdersInd>false</MembersOrStockholdersInd>
      <ElectionOfBoardMembersInd>false</ElectionOfBoardMembersInd>
      <DecisionsSubjectToApprovaInd>false</DecisionsSubjectToApprovaInd>
      <MinutesOfGoverningBodyInd>true</MinutesOfGoverningBodyInd>
      <MinutesOfCommitteesInd>true</MinutesOfCommitteesInd>
      <OfficerMailingAddressInd>false</OfficerMailingAddressInd>
      <LocalChaptersInd>false</LocalChaptersInd>
      <Form990ProvidedToGvrnBodyInd>true</Form990ProvidedToGvrnBodyInd>
      <ConflictOfInterestPolicyInd>true</ConflictOfInterestPolicyInd>
      <AnnualDisclosureCoveredPrsnInd>true</AnnualDisclosureCoveredPrsnInd>
      <RegularMonitoringEnfrcInd>true</RegularMonitoringEnfrcInd>
      <WhistleblowerPolicyInd>true</WhistleblowerPolicyInd>
      <DocumentRetentionPolicyInd>false</DocumentRetentionPolicyInd>
      <CompensationProcessCEOInd>false</CompensationProcessCEOInd>
      <CompensationProcessOtherInd>false</CompensationProcessOtherInd>
      <InvestmentInJointVentureInd>true</InvestmentInJointVentureInd>
      <WrittenPolicyOrProcedureInd>true</WrittenPolicyOrProcedureInd>
      <UponRequestInd>X</UponRequestInd>
      <BooksInCareOfDetail>
        <PersonNm>PETER YANUL</PersonNm>
        <PhoneNum>2563270400</PhoneNum>
        <USAddress>
          <AddressLine1Txt>601 GENOME WAY</AddressLine1Txt>
          <CityNm>HUNTSVILLE</CityNm>
          <StateAbbreviationCd>AL</StateAbbreviationCd>
          <ZIPCd>35806</ZIPCd>
        </USAddress>
      </BooksInCareOfDetail>
      <Form990PartVIISectionAGrp>
        <PersonNm>RICHARD MYERS</PersonNm>
        <TitleTxt>PRESIDENT</TitleTxt>
        <AverageHoursPerWeekRt>40.00</AverageHoursPerWeekRt>
        <OfficerInd>X</OfficerInd>
        <ReportableCompFromOrgAmt>780725</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>33800</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>SHAWN LEVY</PersonNm>
        <TitleTxt>PRINCIPAL IN</TitleTxt>
        <AverageHoursPerWeekRt>40.00</AverageHoursPerWeekRt>
        <KeyEmployeeInd>X</KeyEmployeeInd>
        <ReportableCompFromOrgAmt>559348</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>20738</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>DAVID P BICK</PersonNm>
        <TitleTxt>PRINCIPAL IN</TitleTxt>
        <AverageHoursPerWeekRt>40.00</AverageHoursPerWeekRt>
        <KeyEmployeeInd>X</KeyEmployeeInd>
        <ReportableCompFromOrgAmt>358688</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>35593</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>GREGORY BARSH</PersonNm>
        <TitleTxt>PRINCIPAL IN</TitleTxt>
        <AverageHoursPerWeekRt>40.00</AverageHoursPerWeekRt>
        <KeyEmployeeInd>X</KeyEmployeeInd>
        <ReportableCompFromOrgAmt>348103</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>33800</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>NEIL LAMB</PersonNm>
        <TitleTxt>VP OF ED. OU</TitleTxt>
        <AverageHoursPerWeekRt>40.00</AverageHoursPerWeekRt>
        <OfficerInd>X</OfficerInd>
        <ReportableCompFromOrgAmt>293855</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>27245</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>JEREMY SCHMUTZ</PersonNm>
        <TitleTxt>PRINCIPAL IN</TitleTxt>
        <AverageHoursPerWeekRt>40.00</AverageHoursPerWeekRt>
        <KeyEmployeeInd>X</KeyEmployeeInd>
        <ReportableCompFromOrgAmt>291450</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>29012</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>CARTER WELLS</PersonNm>
        <TitleTxt>VP ECON DEVE</TitleTxt>
        <AverageHoursPerWeekRt>40.00</AverageHoursPerWeekRt>
        <OfficerInd>X</OfficerInd>
        <ReportableCompFromOrgAmt>292219</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>11520</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>DANNY WINDHAM</PersonNm>
        <TitleTxt>COO</TitleTxt>
        <AverageHoursPerWeekRt>40.00</AverageHoursPerWeekRt>
        <OfficerInd>X</OfficerInd>
        <ReportableCompFromOrgAmt>285600</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>11400</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>JANE GRIMWOOD</PersonNm>
        <TitleTxt>PRIN INVESTG</TitleTxt>
        <AverageHoursPerWeekRt>40.00</AverageHoursPerWeekRt>
        <KeyEmployeeInd>X</KeyEmployeeInd>
        <ReportableCompFromOrgAmt>268794</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>26251</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>DEVIN ABSHER</PersonNm>
        <TitleTxt>PRINCIPAL IN</TitleTxt>
        <AverageHoursPerWeekRt>40.00</AverageHoursPerWeekRt>
        <KeyEmployeeInd>X</KeyEmployeeInd>
        <ReportableCompFromOrgAmt>234109</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>23250</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>ELAINE LYON</PersonNm>
        <TitleTxt>PRINCIPAL IN</TitleTxt>
        <AverageHoursPerWeekRt>40.00</AverageHoursPerWeekRt>
        <KeyEmployeeInd>X</KeyEmployeeInd>
        <ReportableCompFromOrgAmt>234600</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>9384</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>GREGORY COOPER</PersonNm>
        <TitleTxt>PRINCIPAL IN</TitleTxt>
        <AverageHoursPerWeekRt>40.00</AverageHoursPerWeekRt>
        <KeyEmployeeInd>X</KeyEmployeeInd>
        <ReportableCompFromOrgAmt>208091</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>20666</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>PETER YANUL</PersonNm>
        <TitleTxt>CFO</TitleTxt>
        <AverageHoursPerWeekRt>40.00</AverageHoursPerWeekRt>
        <OfficerInd>X</OfficerInd>
        <ReportableCompFromOrgAmt>218484</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>8859</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>SARA COOPER</PersonNm>
        <TitleTxt>PRINCIPAL IN</TitleTxt>
        <AverageHoursPerWeekRt>40.00</AverageHoursPerWeekRt>
        <KeyEmployeeInd>X</KeyEmployeeInd>
        <ReportableCompFromOrgAmt>199822</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>18914</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>JIAN HAN</PersonNm>
        <TitleTxt>PRINCIPAL IN</TitleTxt>
        <AverageHoursPerWeekRt>40.00</AverageHoursPerWeekRt>
        <KeyEmployeeInd>X</KeyEmployeeInd>
        <ReportableCompFromOrgAmt>179277</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>17809</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>GREGG TYREE</PersonNm>
        <TitleTxt>DIR/OPER</TitleTxt>
        <AverageHoursPerWeekRt>40.00</AverageHoursPerWeekRt>
        <KeyEmployeeInd>X</KeyEmployeeInd>
        <ReportableCompFromOrgAmt>185553</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>7422</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>KANKSHITA SWAMINATHAN</PersonNm>
        <TitleTxt>PRINCIPAL IN</TitleTxt>
        <AverageHoursPerWeekRt>40.00</AverageHoursPerWeekRt>
        <KeyEmployeeInd>X</KeyEmployeeInd>
        <ReportableCompFromOrgAmt>164397</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>16223</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>MICHAEL SPEIGLE</PersonNm>
        <TitleTxt>CONTROLLER</TitleTxt>
        <AverageHoursPerWeekRt>40.00</AverageHoursPerWeekRt>
        <KeyEmployeeInd>X</KeyEmployeeInd>
        <ReportableCompFromOrgAmt>162000</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>6600</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>FLORENCIA BEHN</PersonNm>
        <TitleTxt>RESEARCH AFF</TitleTxt>
        <AverageHoursPerWeekRt>40.00</AverageHoursPerWeekRt>
        <KeyEmployeeInd>X</KeyEmployeeInd>
        <ReportableCompFromOrgAmt>159681</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>6547</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>BARBARA FISK</PersonNm>
        <TitleTxt>DIRECTOR</TitleTxt>
        <AverageHoursPerWeekRt>0.20</AverageHoursPerWeekRt>
        <IndividualTrusteeOrDirectorInd>X</IndividualTrusteeOrDirectorInd>
        <ReportableCompFromOrgAmt>0</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>0</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>PAUL GIEROW</PersonNm>
        <TitleTxt>DIRECTOR</TitleTxt>
        <AverageHoursPerWeekRt>0.20</AverageHoursPerWeekRt>
        <IndividualTrusteeOrDirectorInd>X</IndividualTrusteeOrDirectorInd>
        <ReportableCompFromOrgAmt>0</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>0</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>J MILTON HARRIS</PersonNm>
        <TitleTxt>DIRECTOR</TitleTxt>
        <AverageHoursPerWeekRt>0.20</AverageHoursPerWeekRt>
        <IndividualTrusteeOrDirectorInd>X</IndividualTrusteeOrDirectorInd>
        <ReportableCompFromOrgAmt>0</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>0</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>JAMES R HUDSON JR</PersonNm>
        <TitleTxt>DIR/CHAIRMAN</TitleTxt>
        <AverageHoursPerWeekRt>0.20</AverageHoursPerWeekRt>
        <IndividualTrusteeOrDirectorInd>X</IndividualTrusteeOrDirectorInd>
        <ReportableCompFromOrgAmt>0</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>0</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>SAMUEL P MCMANUS</PersonNm>
        <TitleTxt>DIRECTOR</TitleTxt>
        <AverageHoursPerWeekRt>0.20</AverageHoursPerWeekRt>
        <IndividualTrusteeOrDirectorInd>X</IndividualTrusteeOrDirectorInd>
        <ReportableCompFromOrgAmt>0</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>0</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>BRIAN POLLOCK</PersonNm>
        <TitleTxt>DIR/VICE CHA</TitleTxt>
        <AverageHoursPerWeekRt>0.20</AverageHoursPerWeekRt>
        <IndividualTrusteeOrDirectorInd>X</IndividualTrusteeOrDirectorInd>
        <ReportableCompFromOrgAmt>0</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>0</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>BOB RILEY</PersonNm>
        <TitleTxt>DIRECTOR</TitleTxt>
        <AverageHoursPerWeekRt>0.20</AverageHoursPerWeekRt>
        <IndividualTrusteeOrDirectorInd>X</IndividualTrusteeOrDirectorInd>
        <ReportableCompFromOrgAmt>0</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>0</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>A EUGENE SAPP</PersonNm>
        <TitleTxt>DIRECTOR</TitleTxt>
        <AverageHoursPerWeekRt>0.20</AverageHoursPerWeekRt>
        <IndividualTrusteeOrDirectorInd>X</IndividualTrusteeOrDirectorInd>
        <ReportableCompFromOrgAmt>0</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>0</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>LINDA SMITH</PersonNm>
        <TitleTxt>DIRECTOR</TitleTxt>
        <AverageHoursPerWeekRt>0.20</AverageHoursPerWeekRt>
        <IndividualTrusteeOrDirectorInd>X</IndividualTrusteeOrDirectorInd>
        <ReportableCompFromOrgAmt>0</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>0</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>IRMA TUDER</PersonNm>
        <TitleTxt>DIRECTOR</TitleTxt>
        <AverageHoursPerWeekRt>0.20</AverageHoursPerWeekRt>
        <IndividualTrusteeOrDirectorInd>X</IndividualTrusteeOrDirectorInd>
        <ReportableCompFromOrgAmt>0</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>0</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>JOHN R WYNN</PersonNm>
        <TitleTxt>SECRETARY</TitleTxt>
        <AverageHoursPerWeekRt>0.20</AverageHoursPerWeekRt>
        <IndividualTrusteeOrDirectorInd>X</IndividualTrusteeOrDirectorInd>
        <ReportableCompFromOrgAmt>0</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>0</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <TotalReportableCompFromOrgAmt>5424796</TotalReportableCompFromOrgAmt>
      <TotalOtherCompensationAmt>365033</TotalOtherCompensationAmt>
      <IndivRcvdGreaterThan100KCnt>19</IndivRcvdGreaterThan100KCnt>
      <FormerOfcrEmployeesListedInd>false</FormerOfcrEmployeesListedInd>
      <TotalCompGreaterThan150KInd>true</TotalCompGreaterThan150KInd>
      <CompensationFromOtherSrcsInd>false</CompensationFromOtherSrcsInd>
      <ContractorCompensationGrp>
        <ContractorName>
          <BusinessName>
            <BusinessNameLine1Txt>DISCOVERY LIFE SCIENCES</BusinessNameLine1Txt>
          </BusinessName>
        </ContractorName>
        <ContractorAddress>
          <USAddress>
            <AddressLine1Txt>800 HUDSON WAY</AddressLine1Txt>
            <AddressLine2Txt>SUITE 1700</AddressLine2Txt>
            <CityNm>HUNTSVILLE</CityNm>
            <StateAbbreviationCd>AL</StateAbbreviationCd>
            <ZIPCd>35806</ZIPCd>
          </USAddress>
        </ContractorAddress>
        <ServicesDesc>SEQUENCING</ServicesDesc>
        <CompensationAmt>6833584</CompensationAmt>
      </ContractorCompensationGrp>
      <ContractorCompensationGrp>
        <ContractorName>
          <BusinessName>
            <BusinessNameLine1Txt>PRESIDIO NETWORKED SOLUTIONS LLC</BusinessNameLine1Txt>
          </BusinessName>
        </ContractorName>
        <ContractorAddress>
          <USAddress>
            <AddressLine1Txt>12100 SUNSET HILLS ROAD</AddressLine1Txt>
            <AddressLine2Txt>SUITE 300</AddressLine2Txt>
            <CityNm>RESTON</CityNm>
            <StateAbbreviationCd>VA</StateAbbreviationCd>
            <ZIPCd>20190</ZIPCd>
          </USAddress>
        </ContractorAddress>
        <ServicesDesc>IT EQUIPMENT</ServicesDesc>
        <CompensationAmt>897485</CompensationAmt>
      </ContractorCompensationGrp>
      <ContractorCompensationGrp>
        <ContractorName>
          <BusinessName>
            <BusinessNameLine1Txt>BRADLEY ARANT</BusinessNameLine1Txt>
          </BusinessName>
        </ContractorName>
        <ContractorAddress>
          <USAddress>
            <AddressLine1Txt>200 CLINTON AVENUE WEST</AddressLine1Txt>
            <CityNm>HUNTSVILLE</CityNm>
            <StateAbbreviationCd>AL</StateAbbreviationCd>
            <ZIPCd>35801</ZIPCd>
          </USAddress>
        </ContractorAddress>
        <ServicesDesc>LEGAL SERVICES</ServicesDesc>
        <CompensationAmt>439251</CompensationAmt>
      </ContractorCompensationGrp>
      <ContractorCompensationGrp>
        <ContractorName>
          <BusinessName>
            <BusinessNameLine1Txt>MERCURY PUBLIC AFFAIRS LLC</BusinessNameLine1Txt>
          </BusinessName>
        </ContractorName>
        <ContractorAddress>
          <USAddress>
            <AddressLine1Txt>1285 AVENUE OF THE AMERICAS</AddressLine1Txt>
            <CityNm>NEW YORK</CityNm>
            <StateAbbreviationCd>NY</StateAbbreviationCd>
            <ZIPCd>10019</ZIPCd>
          </USAddress>
        </ContractorAddress>
        <ServicesDesc>CONSULTING</ServicesDesc>
        <CompensationAmt>241595</CompensationAmt>
      </ContractorCompensationGrp>
      <ContractorCompensationGrp>
        <ContractorName>
          <BusinessName>
            <BusinessNameLine1Txt>CORPORATE BILLING LLC</BusinessNameLine1Txt>
          </BusinessName>
        </ContractorName>
        <ContractorAddress>
          <USAddress>
            <AddressLine1Txt>DEPT 100 PO BOX 830604</AddressLine1Txt>
            <CityNm>BIRMINGHAM</CityNm>
            <StateAbbreviationCd>AL</StateAbbreviationCd>
            <ZIPCd>35283</ZIPCd>
          </USAddress>
        </ContractorAddress>
        <ServicesDesc>LANDSCAPING</ServicesDesc>
        <CompensationAmt>224541</CompensationAmt>
      </ContractorCompensationGrp>
      <CntrctRcvdGreaterThan100KCnt>8</CntrctRcvdGreaterThan100KCnt>
      <RelatedOrganizationsAmt>1736758</RelatedOrganizationsAmt>
      <GovernmentGrantsAmt>41119543</GovernmentGrantsAmt>
      <AllOtherContributionsAmt>11650493</AllOtherContributionsAmt>
      <TotalContributionsAmt>54506794</TotalContributionsAmt>
      <ProgramServiceRevenueGrp>
        <Desc>SERVICE REVENUE</Desc>
        <TotalRevenueColumnAmt>2320338</TotalRevenueColumnAmt>
        <RelatedOrExemptFuncIncomeAmt>2320338</RelatedOrExemptFuncIncomeAmt>
      </ProgramServiceRevenueGrp>
      <TotalProgramServiceRevenueAmt>2320338</TotalProgramServiceRevenueAmt>
      <InvestmentIncomeGrp>
        <TotalRevenueColumnAmt>307618</TotalRevenueColumnAmt>
        <ExclusionAmt>307618</ExclusionAmt>
      </InvestmentIncomeGrp>
      <RoyaltiesRevenueGrp>
        <TotalRevenueColumnAmt>39639</TotalRevenueColumnAmt>
        <ExclusionAmt>39639</ExclusionAmt>
      </RoyaltiesRevenueGrp>
      <GrossRentsGrp>
        <RealAmt>3786975</RealAmt>
      </GrossRentsGrp>
      <RentalIncomeOrLossGrp>
        <RealAmt>3786975</RealAmt>
      </RentalIncomeOrLossGrp>
      <NetRentalIncomeOrLossGrp>
        <TotalRevenueColumnAmt>3786975</TotalRevenueColumnAmt>
        <ExclusionAmt>3786975</ExclusionAmt>
      </NetRentalIncomeOrLossGrp>
      <GrossAmountSalesAssetsGrp>
        <SecuritiesAmt>1191239</SecuritiesAmt>
      </GrossAmountSalesAssetsGrp>
      <LessCostOthBasisSalesExpnssGrp>
        <SecuritiesAmt>1002750</SecuritiesAmt>
      </LessCostOthBasisSalesExpnssGrp>
      <GainOrLossGrp>
        <SecuritiesAmt>188489</SecuritiesAmt>
      </GainOrLossGrp>
      <NetGainOrLossInvestmentsGrp>
        <TotalRevenueColumnAmt>188489</TotalRevenueColumnAmt>
        <RelatedOrExemptFuncIncomeAmt>188489</RelatedOrExemptFuncIncomeAmt>
      </NetGainOrLossInvestmentsGrp>
      <OtherRevenueMiscGrp>
        <Desc>OTHER INCOME</Desc>
        <TotalRevenueColumnAmt>752495</TotalRevenueColumnAmt>
        <RelatedOrExemptFuncIncomeAmt>752495</RelatedOrExemptFuncIncomeAmt>
      </OtherRevenueMiscGrp>
      <OtherRevenueMiscGrp>
        <Desc>SPONSORSHIP REVENUE</Desc>
        <TotalRevenueColumnAmt>30000</TotalRevenueColumnAmt>
        <RelatedOrExemptFuncIncomeAmt>30000</RelatedOrExemptFuncIncomeAmt>
      </OtherRevenueMiscGrp>
      <OtherRevenueMiscGrp>
        <Desc>EVENT REGISTRATION</Desc>
        <TotalRevenueColumnAmt>19152</TotalRevenueColumnAmt>
        <RelatedOrExemptFuncIncomeAmt>19152</RelatedOrExemptFuncIncomeAmt>
      </OtherRevenueMiscGrp>
      <MiscellaneousRevenueGrp>
        <TotalRevenueColumnAmt>-10146063</TotalRevenueColumnAmt>
        <UnrelatedBusinessRevenueAmt>-10146063</UnrelatedBusinessRevenueAmt>
      </MiscellaneousRevenueGrp>
      <OtherRevenueTotalAmt>-9344416</OtherRevenueTotalAmt>
      <TotalRevenueGrp>
        <TotalRevenueColumnAmt>51805437</TotalRevenueColumnAmt>
        <RelatedOrExemptFuncIncomeAmt>3310474</RelatedOrExemptFuncIncomeAmt>
        <UnrelatedBusinessRevenueAmt>-10146063</UnrelatedBusinessRevenueAmt>
        <ExclusionAmt>4134232</ExclusionAmt>
      </TotalRevenueGrp>
      <CompCurrentOfcrDirectorsGrp>
        <TotalAmt>5424797</TotalAmt>
        <ProgramServicesAmt>1163297</ProgramServicesAmt>
        <ManagementAndGeneralAmt>4261500</ManagementAndGeneralAmt>
      </CompCurrentOfcrDirectorsGrp>
      <OtherSalariesAndWagesGrp>
        <TotalAmt>2706732</TotalAmt>
        <ProgramServicesAmt>2040929</ProgramServicesAmt>
        <ManagementAndGeneralAmt>359898</ManagementAndGeneralAmt>
        <FundraisingAmt>305905</FundraisingAmt>
      </OtherSalariesAndWagesGrp>
      <PensionPlanContributionsGrp>
        <TotalAmt>806686</TotalAmt>
        <ProgramServicesAmt>553513</ProgramServicesAmt>
        <ManagementAndGeneralAmt>239488</ManagementAndGeneralAmt>
        <FundraisingAmt>13685</FundraisingAmt>
      </PensionPlanContributionsGrp>
      <OtherEmployeeBenefitsGrp>
        <TotalAmt>2941229</TotalAmt>
        <ProgramServicesAmt>1667509</ProgramServicesAmt>
        <ManagementAndGeneralAmt>1176558</ManagementAndGeneralAmt>
        <FundraisingAmt>97162</FundraisingAmt>
      </OtherEmployeeBenefitsGrp>
      <PayrollTaxesGrp>
        <TotalAmt>1116370</TotalAmt>
        <ProgramServicesAmt>736802</ProgramServicesAmt>
        <ManagementAndGeneralAmt>354066</ManagementAndGeneralAmt>
        <FundraisingAmt>25502</FundraisingAmt>
      </PayrollTaxesGrp>
      <FeesForServicesLegalGrp>
        <TotalAmt>453426</TotalAmt>
        <ProgramServicesAmt>212684</ProgramServicesAmt>
        <ManagementAndGeneralAmt>240742</ManagementAndGeneralAmt>
      </FeesForServicesLegalGrp>
      <FeesForServicesAccountingGrp>
        <TotalAmt>146100</TotalAmt>
        <ManagementAndGeneralAmt>146100</ManagementAndGeneralAmt>
      </FeesForServicesAccountingGrp>
      <FeesForServicesLobbyingGrp>
        <TotalAmt>246250</TotalAmt>
        <ProgramServicesAmt>246250</ProgramServicesAmt>
      </FeesForServicesLobbyingGrp>
      <FeesForServicesProfFundraising>
        <TotalAmt>57667</TotalAmt>
        <FundraisingAmt>57667</FundraisingAmt>
      </FeesForServicesProfFundraising>
      <FeesForSrvcInvstMgmntFeesGrp>
        <TotalAmt>19607</TotalAmt>
        <ProgramServicesAmt>19607</ProgramServicesAmt>
      </FeesForSrvcInvstMgmntFeesGrp>
      <FeesForServicesOtherGrp>
        <TotalAmt>2738</TotalAmt>
        <ProgramServicesAmt>1141</ProgramServicesAmt>
        <ManagementAndGeneralAmt>1597</ManagementAndGeneralAmt>
      </FeesForServicesOtherGrp>
      <AdvertisingGrp>
        <TotalAmt>103398</TotalAmt>
        <ProgramServicesAmt>87984</ProgramServicesAmt>
        <ManagementAndGeneralAmt>6634</ManagementAndGeneralAmt>
        <FundraisingAmt>8780</FundraisingAmt>
      </AdvertisingGrp>
      <OfficeExpensesGrp>
        <TotalAmt>491231</TotalAmt>
        <ProgramServicesAmt>304348</ProgramServicesAmt>
        <ManagementAndGeneralAmt>174041</ManagementAndGeneralAmt>
        <FundraisingAmt>12842</FundraisingAmt>
      </OfficeExpensesGrp>
      <InformationTechnologyGrp>
        <TotalAmt>3058376</TotalAmt>
        <ProgramServicesAmt>149945</ProgramServicesAmt>
        <ManagementAndGeneralAmt>2889075</ManagementAndGeneralAmt>
        <FundraisingAmt>19356</FundraisingAmt>
      </InformationTechnologyGrp>
      <OccupancyGrp>
        <TotalAmt>8716529</TotalAmt>
        <ProgramServicesAmt>7213799</ProgramServicesAmt>
        <ManagementAndGeneralAmt>1494013</ManagementAndGeneralAmt>
        <FundraisingAmt>8717</FundraisingAmt>
      </OccupancyGrp>
      <TravelGrp>
        <TotalAmt>43750</TotalAmt>
        <ProgramServicesAmt>27133</ProgramServicesAmt>
        <ManagementAndGeneralAmt>14368</ManagementAndGeneralAmt>
        <FundraisingAmt>2249</FundraisingAmt>
      </TravelGrp>
      <InterestGrp>
        <TotalAmt>1331</TotalAmt>
        <ManagementAndGeneralAmt>1331</ManagementAndGeneralAmt>
      </InterestGrp>
      <DepreciationDepletionGrp>
        <TotalAmt>1667022</TotalAmt>
        <ProgramServicesAmt>883360</ProgramServicesAmt>
        <ManagementAndGeneralAmt>776089</ManagementAndGeneralAmt>
        <FundraisingAmt>7573</FundraisingAmt>
      </DepreciationDepletionGrp>
      <InsuranceGrp>
        <TotalAmt>232076</TotalAmt>
        <ProgramServicesAmt>32715</ProgramServicesAmt>
        <ManagementAndGeneralAmt>199361</ManagementAndGeneralAmt>
      </InsuranceGrp>
      <OtherExpensesGrp>
        <Desc>DIRECT EXPENDITURES</Desc>
        <TotalAmt>25758234</TotalAmt>
        <ProgramServicesAmt>25380195</ProgramServicesAmt>
        <ManagementAndGeneralAmt>378039</ManagementAndGeneralAmt>
      </OtherExpensesGrp>
      <OtherExpensesGrp>
        <Desc>OUTSIDE SERVICES</Desc>
        <TotalAmt>1937264</TotalAmt>
        <ProgramServicesAmt>358410</ProgramServicesAmt>
        <ManagementAndGeneralAmt>1566394</ManagementAndGeneralAmt>
        <FundraisingAmt>12460</FundraisingAmt>
      </OtherExpensesGrp>
      <OtherExpensesGrp>
        <Desc>CONSULTING FEES</Desc>
        <TotalAmt>529347</TotalAmt>
        <ProgramServicesAmt>212276</ProgramServicesAmt>
        <ManagementAndGeneralAmt>317071</ManagementAndGeneralAmt>
      </OtherExpensesGrp>
      <OtherExpensesGrp>
        <Desc>MAINTENANCE</Desc>
        <TotalAmt>515595</TotalAmt>
        <ProgramServicesAmt>48676</ProgramServicesAmt>
        <ManagementAndGeneralAmt>465850</ManagementAndGeneralAmt>
        <FundraisingAmt>1069</FundraisingAmt>
      </OtherExpensesGrp>
      <AllOtherExpensesGrp>
        <TotalAmt>603867</TotalAmt>
        <ProgramServicesAmt>-106229</ProgramServicesAmt>
        <ManagementAndGeneralAmt>670007</ManagementAndGeneralAmt>
        <FundraisingAmt>40089</FundraisingAmt>
      </AllOtherExpensesGrp>
      <TotalFunctionalExpensesGrp>
        <TotalAmt>57579622</TotalAmt>
        <ProgramServicesAmt>41234344</ProgramServicesAmt>
        <ManagementAndGeneralAmt>15732222</ManagementAndGeneralAmt>
        <FundraisingAmt>613056</FundraisingAmt>
      </TotalFunctionalExpensesGrp>
      <CashNonInterestBearingGrp>
        <BOYAmt>29200419</BOYAmt>
        <EOYAmt>10655430</EOYAmt>
      </CashNonInterestBearingGrp>
      <SavingsAndTempCashInvstGrp>
        <EOYAmt>15431544</EOYAmt>
      </SavingsAndTempCashInvstGrp>
      <PledgesAndGrantsReceivableGrp>
        <BOYAmt>2315501</BOYAmt>
        <EOYAmt>22278937</EOYAmt>
      </PledgesAndGrantsReceivableGrp>
      <AccountsReceivableGrp>
        <BOYAmt>18918258</BOYAmt>
        <EOYAmt>21944663</EOYAmt>
      </AccountsReceivableGrp>
      <PrepaidExpensesDefrdChargesGrp>
        <BOYAmt>564480</BOYAmt>
        <EOYAmt>1360581</EOYAmt>
      </PrepaidExpensesDefrdChargesGrp>
      <LandBldgEquipCostOrOtherBssAmt>139968471</LandBldgEquipCostOrOtherBssAmt>
      <LandBldgEquipAccumDeprecAmt>43653495</LandBldgEquipAccumDeprecAmt>
      <LandBldgEquipBasisNetGrp>
        <BOYAmt>97190994</BOYAmt>
        <EOYAmt>96314976</EOYAmt>
      </LandBldgEquipBasisNetGrp>
      <InvestmentsPubTradedSecGrp>
        <BOYAmt>2361672</BOYAmt>
        <EOYAmt>2742005</EOYAmt>
      </InvestmentsPubTradedSecGrp>
      <InvestmentsOtherSecuritiesGrp>
        <BOYAmt>39512000</BOYAmt>
        <EOYAmt>39512000</EOYAmt>
      </InvestmentsOtherSecuritiesGrp>
      <IntangibleAssetsGrp>
        <BOYAmt>358689</BOYAmt>
        <EOYAmt>399119</EOYAmt>
      </IntangibleAssetsGrp>
      <OtherAssetsTotalGrp>
        <BOYAmt>3651524</BOYAmt>
        <EOYAmt>872801</EOYAmt>
      </OtherAssetsTotalGrp>
      <TotalAssetsGrp>
        <BOYAmt>194073537</BOYAmt>
        <EOYAmt>211512056</EOYAmt>
      </TotalAssetsGrp>
      <AccountsPayableAccrExpnssGrp>
        <BOYAmt>2657311</BOYAmt>
        <EOYAmt>4091373</EOYAmt>
      </AccountsPayableAccrExpnssGrp>
      <DeferredRevenueGrp>
        <EOYAmt>1448394</EOYAmt>
      </DeferredRevenueGrp>
      <OtherLiabilitiesGrp>
        <BOYAmt>4702241</BOYAmt>
        <EOYAmt>14730982</EOYAmt>
      </OtherLiabilitiesGrp>
      <TotalLiabilitiesGrp>
        <BOYAmt>7359552</BOYAmt>
        <EOYAmt>20270749</EOYAmt>
      </TotalLiabilitiesGrp>
      <OrganizationFollowsFASB117Ind>X</OrganizationFollowsFASB117Ind>
      <NoDonorRestrictionNetAssetsGrp>
        <BOYAmt>185964783</BOYAmt>
        <EOYAmt>190516029</EOYAmt>
      </NoDonorRestrictionNetAssetsGrp>
      <DonorRestrictionNetAssetsGrp>
        <BOYAmt>749202</BOYAmt>
        <EOYAmt>725278</EOYAmt>
      </DonorRestrictionNetAssetsGrp>
      <TotalNetAssetsFundBalanceGrp>
        <BOYAmt>186713985</BOYAmt>
        <EOYAmt>191241307</EOYAmt>
      </TotalNetAssetsFundBalanceGrp>
      <TotLiabNetAssetsFundBalanceGrp>
        <BOYAmt>194073537</BOYAmt>
        <EOYAmt>211512056</EOYAmt>
      </TotLiabNetAssetsFundBalanceGrp>
      <InfoInScheduleOPartXIInd>X</InfoInScheduleOPartXIInd>
      <ReconcilationRevenueExpnssAmt>-5774185</ReconcilationRevenueExpnssAmt>
      <NetUnrlzdGainsLossesInvstAmt>158819</NetUnrlzdGainsLossesInvstAmt>
      <PriorPeriodAdjustmentsAmt>29140</PriorPeriodAdjustmentsAmt>
      <OtherChangesInNetAssetsAmt>10113548</OtherChangesInNetAssetsAmt>
      <MethodOfAccountingAccrualInd>X</MethodOfAccountingAccrualInd>
      <AccountantCompileOrReviewInd>false</AccountantCompileOrReviewInd>
      <FSAuditedInd>true</FSAuditedInd>
      <FSAuditedBasisGrp>
        <ConsolidatedBasisFinclStmtInd>X</ConsolidatedBasisFinclStmtInd>
      </FSAuditedBasisGrp>
      <AuditCommitteeInd>true</AuditCommitteeInd>
      <FederalGrantAuditRequiredInd>true</FederalGrantAuditRequiredInd>
      <FederalGrantAuditPerformedInd>true</FederalGrantAuditPerformedInd>
    </IRS990>
    <IRS990ScheduleA documentId="RetDoc9">
      <PublicOrganization170Ind>X</PublicOrganization170Ind>
      <GiftsGrantsContriRcvd170Grp>
        <CurrentTaxYearMinus4YearsAmt>43947417</CurrentTaxYearMinus4YearsAmt>
        <CurrentTaxYearMinus3YearsAmt>23581451</CurrentTaxYearMinus3YearsAmt>
        <CurrentTaxYearMinus2YearsAmt>45424175</CurrentTaxYearMinus2YearsAmt>
        <CurrentTaxYearMinus1YearAmt>31595656</CurrentTaxYearMinus1YearAmt>
        <CurrentTaxYearAmt>54506794</CurrentTaxYearAmt>
        <TotalAmt>199055493</TotalAmt>
      </GiftsGrantsContriRcvd170Grp>
      <TotalCalendarYear170Grp>
        <CurrentTaxYearMinus4YearsAmt>43947417</CurrentTaxYearMinus4YearsAmt>
        <CurrentTaxYearMinus3YearsAmt>23581451</CurrentTaxYearMinus3YearsAmt>
        <CurrentTaxYearMinus2YearsAmt>45424175</CurrentTaxYearMinus2YearsAmt>
        <CurrentTaxYearMinus1YearAmt>31595656</CurrentTaxYearMinus1YearAmt>
        <CurrentTaxYearAmt>54506794</CurrentTaxYearAmt>
        <TotalAmt>199055493</TotalAmt>
      </TotalCalendarYear170Grp>
      <SubstantialContributorsTotAmt>39809600</SubstantialContributorsTotAmt>
      <PublicSupportTotal170Amt>159245893</PublicSupportTotal170Amt>
      <GrossInvestmentIncome170Grp>
        <CurrentTaxYearMinus4YearsAmt>2051544</CurrentTaxYearMinus4YearsAmt>
        <CurrentTaxYearMinus3YearsAmt>2615117</CurrentTaxYearMinus3YearsAmt>
        <CurrentTaxYearMinus2YearsAmt>2390634</CurrentTaxYearMinus2YearsAmt>
        <CurrentTaxYearMinus1YearAmt>3537134</CurrentTaxYearMinus1YearAmt>
        <CurrentTaxYearAmt>4134232</CurrentTaxYearAmt>
        <TotalAmt>14728661</TotalAmt>
      </GrossInvestmentIncome170Grp>
      <TotalSupportAmt>213784154</TotalSupportAmt>
      <GrossReceiptsRltdActivitiesAmt>75841865</GrossReceiptsRltdActivitiesAmt>
      <PublicSupportCY170Pct>0.74490</PublicSupportCY170Pct>
      <PublicSupportPY170Pct>0.81900</PublicSupportPY170Pct>
      <ThirtyThrPctSuprtTestsCY170Ind>X</ThirtyThrPctSuprtTestsCY170Ind>
    </IRS990ScheduleA>
    <IRS990ScheduleB documentId="RetDoc1">
      <ContributorInformationGrp>
        <ContributorNum>RESTRICTED</ContributorNum>
        <ContributorBusinessName>
          <BusinessNameLine1>RESTRICTED</BusinessNameLine1>
        </ContributorBusinessName>
        <ContributorUSAddress>
          <AddressLine1>RESTRICTED</AddressLine1>
          <AddressLine2>RESTRICTED</AddressLine2>
          <City>RESTRICTED</City>
          <State>RESTRICTED</State>
          <ZIPCode>RESTRICTED</ZIPCode>
        </ContributorUSAddress>
        <TotalContributionsAmt>RESTRICTED</TotalContributionsAmt>
      </ContributorInformationGrp>
    </IRS990ScheduleB>
    <IRS990ScheduleC documentId="RetDoc3">
      <VolunteersInd>false</VolunteersInd>
      <PaidStaffOrManagementInd>false</PaidStaffOrManagementInd>
      <MediaAdvertisementsInd>false</MediaAdvertisementsInd>
      <MailingsMembersInd>false</MailingsMembersInd>
      <PublicationsOrBroadcastInd>false</PublicationsOrBroadcastInd>
      <GrantsOtherOrganizationsInd>false</GrantsOtherOrganizationsInd>
      <DirectContactLegislatorsInd>true</DirectContactLegislatorsInd>
      <DirectContactLegislatorsAmt>246250</DirectContactLegislatorsAmt>
      <RalliesDemonstrationsInd>false</RalliesDemonstrationsInd>
      <OtherActivitiesInd>false</OtherActivitiesInd>
      <TotalLobbyingExpendituresAmt>246250</TotalLobbyingExpendituresAmt>
      <NotDescribedSection501c3Ind>false</NotDescribedSection501c3Ind>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>SCHEDULE C, PART II-B, LINE 1</FormAndLineReferenceDesc>
        <ExplanationTxt>PAYMENTS TO LOBBYING ORGANIZATIONS FOR STATE AND LOCAL REPRESENTATION</ExplanationTxt>
      </SupplementalInformationDetail>
    </IRS990ScheduleC>
    <IRS990ScheduleD documentId="RetDoc4">
      <CYMinus4YrEndwmtFundGrp>
        <BeginningYearBalanceAmt>54112</BeginningYearBalanceAmt>
        <OtherExpendituresAmt>54112</OtherExpendituresAmt>
      </CYMinus4YrEndwmtFundGrp>
      <BoardDesignatedBalanceEOYPct>1.00000</BoardDesignatedBalanceEOYPct>
      <EndowmentsHeldUnrelatedOrgInd>false</EndowmentsHeldUnrelatedOrgInd>
      <EndowmentsHeldRelatedOrgInd>false</EndowmentsHeldRelatedOrgInd>
      <LandGrp>
        <OtherCostOrOtherBasisAmt>9004798</OtherCostOrOtherBasisAmt>
        <BookValueAmt>9004798</BookValueAmt>
      </LandGrp>
      <BuildingsGrp>
        <OtherCostOrOtherBasisAmt>104806240</OtherCostOrOtherBasisAmt>
        <DepreciationAmt>24008932</DepreciationAmt>
        <BookValueAmt>80797308</BookValueAmt>
      </BuildingsGrp>
      <EquipmentGrp>
        <OtherCostOrOtherBasisAmt>26157433</OtherCostOrOtherBasisAmt>
        <DepreciationAmt>19644563</DepreciationAmt>
        <BookValueAmt>6512870</BookValueAmt>
      </EquipmentGrp>
      <TotalBookValueLandBuildingsAmt>96314976</TotalBookValueLandBuildingsAmt>
      <CloselyHeldEquityInterestsGrp>
        <BookValueAmt>39512000</BookValueAmt>
        <MethodValuationCd>C</MethodValuationCd>
      </CloselyHeldEquityInterestsGrp>
      <TotalBookValueSecuritiesAmt>39512000</TotalBookValueSecuritiesAmt>
      <OtherLiabilitiesOrgGrp>
        <Desc>REFUNDABLE ADVANCE</Desc>
        <Amt>6095509</Amt>
      </OtherLiabilitiesOrgGrp>
      <OtherLiabilitiesOrgGrp>
        <Desc>DUE TO HUDSON ALPHA FOUNDATION</Desc>
        <Amt>5821495</Amt>
      </OtherLiabilitiesOrgGrp>
      <OtherLiabilitiesOrgGrp>
        <Desc>ACCRUED EXPENSES</Desc>
        <Amt>2091110</Amt>
      </OtherLiabilitiesOrgGrp>
      <OtherLiabilitiesOrgGrp>
        <Desc>CAPITAL LEASE</Desc>
        <Amt>513557</Amt>
      </OtherLiabilitiesOrgGrp>
      <OtherLiabilitiesOrgGrp>
        <Desc>DUE TO HUDSON ALPHA SERVICE CORP</Desc>
        <Amt>209311</Amt>
      </OtherLiabilitiesOrgGrp>
      <TotalLiabilityAmt>14730982</TotalLiabilityAmt>
    </IRS990ScheduleD>
    <IRS990ScheduleG documentId="RetDoc5">
      <MailSolicitationsInd>X</MailSolicitationsInd>
      <EmailSolicitationsInd>X</EmailSolicitationsInd>
      <PhoneSolicitationsInd>X</PhoneSolicitationsInd>
      <InPersonSolicitationsInd>X</InPersonSolicitationsInd>
      <SolicitationOfNonGovtGrantsInd>X</SolicitationOfNonGovtGrantsInd>
      <SolicitationOfGovtGrantsInd>X</SolicitationOfGovtGrantsInd>
      <SpecialFundraisingEventsInd>X</SpecialFundraisingEventsInd>
      <AgrmtProfFundraisingActyInd>true</AgrmtProfFundraisingActyInd>
      <FundraiserActivityInfoGrp>
        <PersonNm>CLIPPER RESOURCES GROUP</PersonNm>
        <USAddress>
          <AddressLine1Txt>1734 OXMOOR RD</AddressLine1Txt>
          <CityNm>BIRMINGHAM</CityNm>
          <StateAbbreviationCd>AL</StateAbbreviationCd>
          <ZIPCd>35209</ZIPCd>
        </USAddress>
        <ActivityTxt>ADVANCEMEN</ActivityTxt>
        <FundraiserControlOfFundsInd>false</FundraiserControlOfFundsInd>
        <RetainedByContractorAmt>24000</RetainedByContractorAmt>
        <NetToOrganizationAmt>-24000</NetToOrganizationAmt>
      </FundraiserActivityInfoGrp>
      <FundraiserActivityInfoGrp>
        <PersonNm>EH MURRAY GROUP LLC</PersonNm>
        <USAddress>
          <AddressLine1Txt>1214 A INGLESIDE AVENUE</AddressLine1Txt>
          <CityNm>MCLEAN</CityNm>
          <StateAbbreviationCd>VA</StateAbbreviationCd>
          <ZIPCd>22101</ZIPCd>
        </USAddress>
        <ActivityTxt>ADVANCEMEN</ActivityTxt>
        <FundraiserControlOfFundsInd>false</FundraiserControlOfFundsInd>
        <RetainedByContractorAmt>17000</RetainedByContractorAmt>
        <NetToOrganizationAmt>-17000</NetToOrganizationAmt>
      </FundraiserActivityInfoGrp>
      <FundraiserActivityInfoGrp>
        <PersonNm>THE MESSINA GROUP</PersonNm>
        <USAddress>
          <AddressLine1Txt>1155 CONNECTICUT AVE NW</AddressLine1Txt>
          <CityNm>WASHINGTON</CityNm>
          <StateAbbreviationCd>DC</StateAbbreviationCd>
          <ZIPCd>20036</ZIPCd>
        </USAddress>
        <ActivityTxt>ADVANCEMEN</ActivityTxt>
        <FundraiserControlOfFundsInd>false</FundraiserControlOfFundsInd>
        <RetainedByContractorAmt>16667</RetainedByContractorAmt>
        <NetToOrganizationAmt>-16667</NetToOrganizationAmt>
      </FundraiserActivityInfoGrp>
      <TotalRetainedByContractorsAmt>57667</TotalRetainedByContractorsAmt>
      <TotalNetToOrganizationAmt>-57667</TotalNetToOrganizationAmt>
      <AllStatesCd>All States</AllStatesCd>
    </IRS990ScheduleG>
    <IRS990ScheduleJ documentId="RetDoc6">
      <FirstClassOrCharterTravelInd>X</FirstClassOrCharterTravelInd>
      <WrittenPolicyRefTAndEExpnssInd>true</WrittenPolicyRefTAndEExpnssInd>
      <SubstantiationRequiredInd>true</SubstantiationRequiredInd>
      <BoardOrCommitteeApprovalInd>X</BoardOrCommitteeApprovalInd>
      <SeverancePaymentInd>false</SeverancePaymentInd>
      <SupplementalNonqualRtrPlanInd>false</SupplementalNonqualRtrPlanInd>
      <EquityBasedCompArrngmInd>false</EquityBasedCompArrngmInd>
      <CompBasedOnRevenueOfFlngOrgInd>false</CompBasedOnRevenueOfFlngOrgInd>
      <CompBsdOnRevRelatedOrgsInd>false</CompBsdOnRevRelatedOrgsInd>
      <CompBsdNetEarnsFlngOrgInd>false</CompBsdNetEarnsFlngOrgInd>
      <CompBsdNetEarnsRltdOrgsInd>false</CompBsdNetEarnsRltdOrgsInd>
      <AnyNonFixedPaymentsInd>false</AnyNonFixedPaymentsInd>
      <InitialContractExceptionInd>false</InitialContractExceptionInd>
      <RltdOrgOfficerTrstKeyEmplGrp>
        <PersonNm>RICHARD MYERS</PersonNm>
        <TitleTxt>PRESIDENT</TitleTxt>
        <BaseCompensationFilingOrgAmt>780725</BaseCompensationFilingOrgAmt>
        <DeferredCompensationFlngOrgAmt>33800</DeferredCompensationFlngOrgAmt>
        <TotalCompensationFilingOrgAmt>814525</TotalCompensationFilingOrgAmt>
      </RltdOrgOfficerTrstKeyEmplGrp>
      <RltdOrgOfficerTrstKeyEmplGrp>
        <PersonNm>SHAWN LEVY</PersonNm>
        <TitleTxt>PRINCIPAL INVESTG</TitleTxt>
        <BaseCompensationFilingOrgAmt>559348</BaseCompensationFilingOrgAmt>
        <DeferredCompensationFlngOrgAmt>20738</DeferredCompensationFlngOrgAmt>
        <TotalCompensationFilingOrgAmt>580086</TotalCompensationFilingOrgAmt>
      </RltdOrgOfficerTrstKeyEmplGrp>
      <RltdOrgOfficerTrstKeyEmplGrp>
        <PersonNm>DAVID P BICK</PersonNm>
        <TitleTxt>PRINCIPAL INVESTG</TitleTxt>
        <BaseCompensationFilingOrgAmt>358688</BaseCompensationFilingOrgAmt>
        <DeferredCompensationFlngOrgAmt>35593</DeferredCompensationFlngOrgAmt>
        <TotalCompensationFilingOrgAmt>394281</TotalCompensationFilingOrgAmt>
      </RltdOrgOfficerTrstKeyEmplGrp>
      <RltdOrgOfficerTrstKeyEmplGrp>
        <PersonNm>GREGORY BARSH</PersonNm>
        <TitleTxt>PRINCIPAL INVESTG</TitleTxt>
        <BaseCompensationFilingOrgAmt>348103</BaseCompensationFilingOrgAmt>
        <DeferredCompensationFlngOrgAmt>33800</DeferredCompensationFlngOrgAmt>
        <TotalCompensationFilingOrgAmt>381903</TotalCompensationFilingOrgAmt>
      </RltdOrgOfficerTrstKeyEmplGrp>
      <RltdOrgOfficerTrstKeyEmplGrp>
        <PersonNm>NEIL LAMB</PersonNm>
        <TitleTxt>VP OF ED. OUTREACH</TitleTxt>
        <BaseCompensationFilingOrgAmt>293855</BaseCompensationFilingOrgAmt>
        <DeferredCompensationFlngOrgAmt>27245</DeferredCompensationFlngOrgAmt>
        <TotalCompensationFilingOrgAmt>321100</TotalCompensationFilingOrgAmt>
      </RltdOrgOfficerTrstKeyEmplGrp>
      <RltdOrgOfficerTrstKeyEmplGrp>
        <PersonNm>JEREMY SCHMUTZ</PersonNm>
        <TitleTxt>PRINCIPAL INVESTG</TitleTxt>
        <BaseCompensationFilingOrgAmt>291450</BaseCompensationFilingOrgAmt>
        <DeferredCompensationFlngOrgAmt>29012</DeferredCompensationFlngOrgAmt>
        <TotalCompensationFilingOrgAmt>320462</TotalCompensationFilingOrgAmt>
      </RltdOrgOfficerTrstKeyEmplGrp>
      <RltdOrgOfficerTrstKeyEmplGrp>
        <PersonNm>CARTER WELLS</PersonNm>
        <TitleTxt>VP ECON DEVELOPMENT</TitleTxt>
        <BaseCompensationFilingOrgAmt>292219</BaseCompensationFilingOrgAmt>
        <DeferredCompensationFlngOrgAmt>11520</DeferredCompensationFlngOrgAmt>
        <TotalCompensationFilingOrgAmt>303739</TotalCompensationFilingOrgAmt>
      </RltdOrgOfficerTrstKeyEmplGrp>
      <RltdOrgOfficerTrstKeyEmplGrp>
        <PersonNm>DANNY WINDHAM</PersonNm>
        <TitleTxt>COO</TitleTxt>
        <BaseCompensationFilingOrgAmt>285600</BaseCompensationFilingOrgAmt>
        <DeferredCompensationFlngOrgAmt>11400</DeferredCompensationFlngOrgAmt>
        <TotalCompensationFilingOrgAmt>297000</TotalCompensationFilingOrgAmt>
      </RltdOrgOfficerTrstKeyEmplGrp>
      <RltdOrgOfficerTrstKeyEmplGrp>
        <PersonNm>JANE GRIMWOOD</PersonNm>
        <TitleTxt>PRIN INVESTG</TitleTxt>
        <BaseCompensationFilingOrgAmt>268794</BaseCompensationFilingOrgAmt>
        <DeferredCompensationFlngOrgAmt>26251</DeferredCompensationFlngOrgAmt>
        <TotalCompensationFilingOrgAmt>295045</TotalCompensationFilingOrgAmt>
      </RltdOrgOfficerTrstKeyEmplGrp>
      <RltdOrgOfficerTrstKeyEmplGrp>
        <PersonNm>DEVIN ABSHER</PersonNm>
        <TitleTxt>PRINCIPAL INVESTG</TitleTxt>
        <BaseCompensationFilingOrgAmt>234109</BaseCompensationFilingOrgAmt>
        <DeferredCompensationFlngOrgAmt>23250</DeferredCompensationFlngOrgAmt>
        <TotalCompensationFilingOrgAmt>257359</TotalCompensationFilingOrgAmt>
      </RltdOrgOfficerTrstKeyEmplGrp>
      <RltdOrgOfficerTrstKeyEmplGrp>
        <PersonNm>ELAINE LYON</PersonNm>
        <TitleTxt>PRINCIPAL INVESTG</TitleTxt>
        <BaseCompensationFilingOrgAmt>234600</BaseCompensationFilingOrgAmt>
        <DeferredCompensationFlngOrgAmt>9384</DeferredCompensationFlngOrgAmt>
        <TotalCompensationFilingOrgAmt>243984</TotalCompensationFilingOrgAmt>
      </RltdOrgOfficerTrstKeyEmplGrp>
      <RltdOrgOfficerTrstKeyEmplGrp>
        <PersonNm>GREGORY COOPER</PersonNm>
        <TitleTxt>PRINCIPAL INVESTIGAT</TitleTxt>
        <BaseCompensationFilingOrgAmt>208091</BaseCompensationFilingOrgAmt>
        <DeferredCompensationFlngOrgAmt>20666</DeferredCompensationFlngOrgAmt>
        <TotalCompensationFilingOrgAmt>228757</TotalCompensationFilingOrgAmt>
      </RltdOrgOfficerTrstKeyEmplGrp>
      <RltdOrgOfficerTrstKeyEmplGrp>
        <PersonNm>PETER YANUL</PersonNm>
        <TitleTxt>CFO</TitleTxt>
        <BaseCompensationFilingOrgAmt>218484</BaseCompensationFilingOrgAmt>
        <DeferredCompensationFlngOrgAmt>8859</DeferredCompensationFlngOrgAmt>
        <TotalCompensationFilingOrgAmt>227343</TotalCompensationFilingOrgAmt>
      </RltdOrgOfficerTrstKeyEmplGrp>
      <RltdOrgOfficerTrstKeyEmplGrp>
        <PersonNm>SARA COOPER</PersonNm>
        <TitleTxt>PRINCIPAL INVESTG</TitleTxt>
        <BaseCompensationFilingOrgAmt>199822</BaseCompensationFilingOrgAmt>
        <DeferredCompensationFlngOrgAmt>18914</DeferredCompensationFlngOrgAmt>
        <TotalCompensationFilingOrgAmt>218736</TotalCompensationFilingOrgAmt>
      </RltdOrgOfficerTrstKeyEmplGrp>
      <RltdOrgOfficerTrstKeyEmplGrp>
        <PersonNm>JIAN HAN</PersonNm>
        <TitleTxt>PRINCIPAL INVESTG</TitleTxt>
        <BaseCompensationFilingOrgAmt>179277</BaseCompensationFilingOrgAmt>
        <DeferredCompensationFlngOrgAmt>17809</DeferredCompensationFlngOrgAmt>
        <TotalCompensationFilingOrgAmt>197086</TotalCompensationFilingOrgAmt>
      </RltdOrgOfficerTrstKeyEmplGrp>
      <RltdOrgOfficerTrstKeyEmplGrp>
        <PersonNm>GREGG TYREE</PersonNm>
        <TitleTxt>DIR/OPER</TitleTxt>
        <BaseCompensationFilingOrgAmt>185553</BaseCompensationFilingOrgAmt>
        <DeferredCompensationFlngOrgAmt>7422</DeferredCompensationFlngOrgAmt>
        <TotalCompensationFilingOrgAmt>192975</TotalCompensationFilingOrgAmt>
      </RltdOrgOfficerTrstKeyEmplGrp>
      <RltdOrgOfficerTrstKeyEmplGrp>
        <PersonNm>KANKSHITA SWAMINATHAN</PersonNm>
        <TitleTxt>PRINCIPAL INVESTG</TitleTxt>
        <BaseCompensationFilingOrgAmt>164397</BaseCompensationFilingOrgAmt>
        <DeferredCompensationFlngOrgAmt>16223</DeferredCompensationFlngOrgAmt>
        <TotalCompensationFilingOrgAmt>180620</TotalCompensationFilingOrgAmt>
      </RltdOrgOfficerTrstKeyEmplGrp>
      <RltdOrgOfficerTrstKeyEmplGrp>
        <PersonNm>MICHAEL SPEIGLE</PersonNm>
        <TitleTxt>CONTROLLER</TitleTxt>
        <BaseCompensationFilingOrgAmt>162000</BaseCompensationFilingOrgAmt>
        <DeferredCompensationFlngOrgAmt>6600</DeferredCompensationFlngOrgAmt>
        <TotalCompensationFilingOrgAmt>168600</TotalCompensationFilingOrgAmt>
      </RltdOrgOfficerTrstKeyEmplGrp>
      <RltdOrgOfficerTrstKeyEmplGrp>
        <PersonNm>FLORENCIA BEHN</PersonNm>
        <TitleTxt>RESEARCH AFFAIRS DIR</TitleTxt>
        <BaseCompensationFilingOrgAmt>159681</BaseCompensationFilingOrgAmt>
        <DeferredCompensationFlngOrgAmt>6547</DeferredCompensationFlngOrgAmt>
        <TotalCompensationFilingOrgAmt>166228</TotalCompensationFilingOrgAmt>
      </RltdOrgOfficerTrstKeyEmplGrp>
    </IRS990ScheduleJ>
    <IRS990ScheduleO documentId="RetDoc7">
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990 - ORGANIZATION'S MISSION</FormAndLineReferenceDesc>
        <ExplanationTxt>THE PRIMARY MISSION OF THE INSTITUTE WILL BE TO USE THE INCREASINGLY POWERFUL RESEARCH TOOLS BEING DEVELOPED IN THE BIOTECHNOLOGY AREA TO BETTER UNDERSTAND THE CAUSES OF CERTAIN DISEASES AND TO APPLY THE FINDINGS OF SUCH RESEARCH TO HELP DEVELOP NEW AND MORE EFFECTIVE TREATMENTS FOR SUCH DISEASES. THE INSTITUTE'S CHARITABLE MISSION CONTEMPLATES NUMEROUS OTHER ACTIVITIES ALL OF WHICH ARE INTENDED TO HELP FURTHER BIOTECH RESEARCH IN ALABAMA.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PAGE 2, PART III, LINE 4D</FormAndLineReferenceDesc>
        <ExplanationTxt>ACTIVITIES, PROGRAMS AND COLLABORATIONS FOR THE INSTITUE TO ACCOMPLISH ITS CHARITABLE OBJECTIVE OF CREATING ECONOMIC GROWTH IN BIOTECHNOLOGY RELATED FIELDS</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PAGE 6, PART VI, LINE 11B</FormAndLineReferenceDesc>
        <ExplanationTxt>FORM 990 IS PROVIDED TO THE CFO WHO THEN DISTRIBUTES COPIES TO THE GOVERNING BODY FOR REVIEW.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PAGE 6, PART VI, LINE 12C</FormAndLineReferenceDesc>
        <ExplanationTxt>A CONFLICT OF INTEREST DISCLOSURE IS REVIEWED FOR ANY NEW GRANT, CONTRACT, PROPOSED PARTNERSHIP, OR COLLABORATION.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PAGE 6, PART VI, LINE 19</FormAndLineReferenceDesc>
        <ExplanationTxt>NO DOCUMENTS AVAILABLE TO THE PUBLIC.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART XI, LINE 9</FormAndLineReferenceDesc>
        <ExplanationTxt>K1 BOOK/TAX DIFFERENCE 10,113,548</ExplanationTxt>
      </SupplementalInformationDetail>
    </IRS990ScheduleO>
    <IRS990ScheduleR documentId="RetDoc8">
      <IdDisregardedEntitiesGrp>
        <DisregardedEntityName>
          <BusinessNameLine1Txt>HUDSONALPHA CLINICAL SERVICES LAB</BusinessNameLine1Txt>
        </DisregardedEntityName>
        <USAddress>
          <AddressLine1Txt>601 GENOME WAY</AddressLine1Txt>
          <CityNm>HUNTSVILLE</CityNm>
          <StateAbbreviationCd>AL</StateAbbreviationCd>
          <ZIPCd>35806</ZIPCd>
        </USAddress>
        <EIN>474553847</EIN>
        <PrimaryActivitiesTxt>SERVICES</PrimaryActivitiesTxt>
        <LegalDomicileStateCd>AL</LegalDomicileStateCd>
        <TotalIncomeAmt>1027439</TotalIncomeAmt>
        <EndOfYearAssetsAmt>236896</EndOfYearAssetsAmt>
        <DirectControllingEntityName>
          <BusinessNameLine1Txt>HAIB</BusinessNameLine1Txt>
        </DirectControllingEntityName>
      </IdDisregardedEntitiesGrp>
      <IdDisregardedEntitiesGrp>
        <DisregardedEntityName>
          <BusinessNameLine1Txt>SMITH FAMILY CLINIC FOR GEOMIC</BusinessNameLine1Txt>
          <BusinessNameLine2Txt>MEDICINE LLC</BusinessNameLine2Txt>
        </DisregardedEntityName>
        <USAddress>
          <AddressLine1Txt>601 GENOME WAY</AddressLine1Txt>
          <CityNm>HUNTSVILLE</CityNm>
          <StateAbbreviationCd>AL</StateAbbreviationCd>
          <ZIPCd>35806</ZIPCd>
        </USAddress>
        <EIN>474553450</EIN>
        <PrimaryActivitiesTxt>SERVICES</PrimaryActivitiesTxt>
        <LegalDomicileStateCd>AL</LegalDomicileStateCd>
        <TotalIncomeAmt>40866</TotalIncomeAmt>
        <EndOfYearAssetsAmt>45852</EndOfYearAssetsAmt>
        <DirectControllingEntityName>
          <BusinessNameLine1Txt>HAIB</BusinessNameLine1Txt>
        </DirectControllingEntityName>
      </IdDisregardedEntitiesGrp>
      <IdDisregardedEntitiesGrp>
        <DisregardedEntityName>
          <BusinessNameLine1Txt>HUDSONALPHA HEALTH ALLIANCE LLC</BusinessNameLine1Txt>
        </DisregardedEntityName>
        <USAddress>
          <AddressLine1Txt>601 GENOME WAY</AddressLine1Txt>
          <CityNm>HUNTSVILLE</CityNm>
          <StateAbbreviationCd>AL</StateAbbreviationCd>
          <ZIPCd>35806</ZIPCd>
        </USAddress>
        <EIN>852756175</EIN>
        <PrimaryActivitiesTxt>SERVICES</PrimaryActivitiesTxt>
        <LegalDomicileStateCd>AL</LegalDomicileStateCd>
        <TotalIncomeAmt>78300</TotalIncomeAmt>
        <EndOfYearAssetsAmt>25774</EndOfYearAssetsAmt>
        <DirectControllingEntityName>
          <BusinessNameLine1Txt>HAIB</BusinessNameLine1Txt>
        </DirectControllingEntityName>
      </IdDisregardedEntitiesGrp>
      <IdDisregardedEntitiesGrp>
        <DisregardedEntityName>
          <BusinessNameLine1Txt>TESTING FOR AMERICA LLC</BusinessNameLine1Txt>
        </DisregardedEntityName>
        <USAddress>
          <AddressLine1Txt>601 GENOME WAY</AddressLine1Txt>
          <CityNm>HUNTSVILLE</CityNm>
          <StateAbbreviationCd>AL</StateAbbreviationCd>
          <ZIPCd>35806</ZIPCd>
        </USAddress>
        <EIN>432059317</EIN>
        <PrimaryActivitiesTxt>SERVICE</PrimaryActivitiesTxt>
        <LegalDomicileStateCd>AL</LegalDomicileStateCd>
        <EndOfYearAssetsAmt>2965486</EndOfYearAssetsAmt>
        <DirectControllingEntityName>
          <BusinessNameLine1Txt>HAIB</BusinessNameLine1Txt>
        </DirectControllingEntityName>
      </IdDisregardedEntitiesGrp>
      <IdRelatedTaxExemptOrgGrp>
        <DisregardedEntityName>
          <BusinessNameLine1Txt>HUDSONALPHA FOUNDATION</BusinessNameLine1Txt>
        </DisregardedEntityName>
        <USAddress>
          <AddressLine1Txt>601 GENOME WAY</AddressLine1Txt>
          <CityNm>HUNTSVILLE</CityNm>
          <StateAbbreviationCd>AL</StateAbbreviationCd>
          <ZIPCd>35806</ZIPCd>
        </USAddress>
        <EIN>272320591</EIN>
        <PrimaryActivitiesTxt>ADVANCEMEN</PrimaryActivitiesTxt>
        <LegalDomicileStateCd>AL</LegalDomicileStateCd>
        <ExemptCodeSectionTxt>501C3</ExemptCodeSectionTxt>
        <PublicCharityStatusTxt>7</PublicCharityStatusTxt>
        <DirectControllingNACd>N/A</DirectControllingNACd>
        <ControlledOrganizationInd>false</ControlledOrganizationInd>
      </IdRelatedTaxExemptOrgGrp>
      <IdRelatedOrgTxblCorpTrGrp>
        <RelatedOrganizationName>
          <BusinessNameLine1Txt>HUDSONALPHA SERVICES CORPORATION</BusinessNameLine1Txt>
        </RelatedOrganizationName>
        <USAddress>
          <AddressLine1Txt>601 GENOME WAY</AddressLine1Txt>
          <CityNm>HUNTSVILLE</CityNm>
          <StateAbbreviationCd>AL</StateAbbreviationCd>
          <ZIPCd>35806</ZIPCd>
        </USAddress>
        <EIN>823114735</EIN>
        <PrimaryActivitiesTxt>LEASING</PrimaryActivitiesTxt>
        <LegalDomicileStateCd>AL</LegalDomicileStateCd>
        <DirectControllingNACd>N/A</DirectControllingNACd>
        <EntityTypeTxt>C CORP</EntityTypeTxt>
        <ShareOfEOYAssetsAmt>143</ShareOfEOYAssetsAmt>
        <OwnershipPct>1.00000</OwnershipPct>
        <ControlledOrganizationInd>false</ControlledOrganizationInd>
      </IdRelatedOrgTxblCorpTrGrp>
      <ReceiptOfIntAnntsRntsRyltsInd>false</ReceiptOfIntAnntsRntsRyltsInd>
      <GiftGrntOrCapContriToOthOrgInd>false</GiftGrntOrCapContriToOthOrgInd>
      <GiftGrntCapContriFromOthOrgInd>true</GiftGrntCapContriFromOthOrgInd>
      <LoansOrGuaranteesToOtherOrgInd>false</LoansOrGuaranteesToOtherOrgInd>
      <LoansOrGuaranteesFromOthOrgInd>false</LoansOrGuaranteesFromOthOrgInd>
      <DivRelatedOrganizationInd>false</DivRelatedOrganizationInd>
      <AssetSaleToOtherOrgInd>false</AssetSaleToOtherOrgInd>
      <AssetPurchaseFromOtherOrgInd>false</AssetPurchaseFromOtherOrgInd>
      <AssetExchangeInd>false</AssetExchangeInd>
      <RentalOfFacilitiesToOthOrgInd>false</RentalOfFacilitiesToOthOrgInd>
      <RentalOfFcltsFromOthOrgInd>true</RentalOfFcltsFromOthOrgInd>
      <PerformOfServicesForOthOrgInd>false</PerformOfServicesForOthOrgInd>
      <PerformOfServicesByOtherOrgInd>false</PerformOfServicesByOtherOrgInd>
      <SharingOfFacilitiesInd>true</SharingOfFacilitiesInd>
      <PaidEmployeesSharingInd>true</PaidEmployeesSharingInd>
      <ReimbursementPaidToOtherOrgInd>false</ReimbursementPaidToOtherOrgInd>
      <ReimbursementPaidByOtherOrgInd>false</ReimbursementPaidByOtherOrgInd>
      <TransferToOtherOrgInd>false</TransferToOtherOrgInd>
      <TransferFromOtherOrgInd>false</TransferFromOtherOrgInd>
      <TransactionsRelatedOrgGrp>
        <OtherOrganizationName>
          <BusinessNameLine1Txt>HUDSONALPHA FOUNDATION</BusinessNameLine1Txt>
        </OtherOrganizationName>
        <TransactionTypeTxt>C</TransactionTypeTxt>
        <InvolvedAmt>1736758</InvolvedAmt>
      </TransactionsRelatedOrgGrp>
      <TransactionsRelatedOrgGrp>
        <OtherOrganizationName>
          <BusinessNameLine1Txt>HUDSONALPHA FOUNDATION</BusinessNameLine1Txt>
        </OtherOrganizationName>
        <TransactionTypeTxt>N</TransactionTypeTxt>
      </TransactionsRelatedOrgGrp>
      <TransactionsRelatedOrgGrp>
        <OtherOrganizationName>
          <BusinessNameLine1Txt>HUDSONALPHA FOUNDATION</BusinessNameLine1Txt>
        </OtherOrganizationName>
        <TransactionTypeTxt>O</TransactionTypeTxt>
      </TransactionsRelatedOrgGrp>
      <TransactionsRelatedOrgGrp>
        <OtherOrganizationName>
          <BusinessNameLine1Txt>HUDSONALPHA SERVICES CORPORATION</BusinessNameLine1Txt>
        </OtherOrganizationName>
        <TransactionTypeTxt>K</TransactionTypeTxt>
        <InvolvedAmt>189472</InvolvedAmt>
      </TransactionsRelatedOrgGrp>
    </IRS990ScheduleR>
  </ReturnData>
</Return>
