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        <SharingOfRevenuesInd>0</SharingOfRevenuesInd>
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      <BusTrInvolveInterestedPrsnGrp>
        <NameOfInterested>
          <PersonNm>SATISH K TRIPATHI</PersonNm>
        </NameOfInterested>
        <RelationshipDescriptionTxt>DIRECTOR</RelationshipDescriptionTxt>
        <TransactionAmt>2135921</TransactionAmt>
        <TransactionDesc>RENT AND OTHER SERVICES</TransactionDesc>
        <SharingOfRevenuesInd>0</SharingOfRevenuesInd>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>SCH L, PART IV</FormAndLineReferenceDesc>
        <ExplanationTxt>NAME OF PERSON: GERALD S. LIPPESDESCRIPTION OF TRANSACTION: JACOBS INSTITUTE PAID $150,455 IN LEGAL SERVICES DURING THE YEAR ENDED DECEMBER 31, 2021 TO AN ENTITY AFFILIATED WITH GERALD S. LIPPES.NAME OF PERSON: SATISH K. TRIPATHIDESCRIPTION OF TRANSACTION: RENT WAS INCURRED IN THE AMOUNT OF $125,825 BY THE JACOBS INSTITUTE, INC FROM ENTITIES AFFILIATED WITH THE UNIVERSITY AT BUFFALO. THE JACOBS INSTITUTE ALSO PAID $2,010,096 FOR CONSULTING SERVICES, LAB SUPPLIES AND SERVICES, RESEARCH EXPENSES, TELEPHONE, INTERNET, WEBSITE, AND COMPUTER EXPENSES TO ENTITIES AFFILIATED WITH THE UNIVERSITY AT BUFFALO. SATISH K. TRIPATHI IS THE PRESIDENT OF THE UNIVERSITY AT BUFFALO.</ExplanationTxt>
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    <IRS990ScheduleO documentId="RetDoc1044400001">
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART III, LINE 4A</FormAndLineReferenceDesc>
        <ExplanationTxt>BY CONDUCTING THE PROGRAM SERVICES LISTED BELOW, THE JACOBS INSTITUTE HOPES TO CREATE "COLLISIONS" OF IDEAS BETWEEN ACADEMICS, RESEARCHERS AND CLINICIANS TO PROMOTE CLINICAL CARE, ACADEMIC RESEARCH AND ENTREPRENEURIAL ("CARE") EXCELLENCE IN THE TREATMENT OF GLOBAL VASCULAR DISEASE AND RELATED NEUROLOGICAL DISEASES WITH THE ULTIMATE GOAL THAT THESE "COLLISIONS" WILL LEAD TO IMPROVED TREATMENT OF, AND NEW AND IMPROVED TECHNOLOGY AND INNOVATIONS RELATED TO, GLOBAL VASCULAR DISEASE AND RELATED NEUROLOGICAL DISEASES THAT MAY NOT OTHERWISE ATTRACT SUFFICIENT FUNDING IN WESTERN NEW YORK. RESEARCH/ADVANCEMENTS-PROVIDE STAFFING AND RESEARCH SUPPORT TO ACADEMICS, RESEARCHERS AND CLINICIANS AT: (1) THE STATE UNIVERSITY OF NEW YORK, UNIVERSITY AT BUFFALO ("UNIVERSITY AT BUFFALO"), A 501(C)(3) ORGANIZATION; (2) KALEIDA HEALTH (THE LARGEST HOSPITAL NETWORK IN WESTERN NEW YORK), A 501(C)(3) ORGANIZATION; AND (3) OTHER SIMILAR HEALTH-RELATED 501(C)(3) ORGANIZATIONS SELECTED BY THE MANAGEMENT OF THE JACOBS INSTITUTE; IN ORDER TO FACILITATE THE DEVELOPMENT BY SUCH ORGANIZATION OF: (A) ADVANCEMENTS IN THE TREATMENT OF GLOBAL VASCULAR DISEASE AND RELATED NEUROLOGICAL DISEASE; AND (B) CUTTING EDGE TECHNOLOGIES AND OTHER INFORMATION FOR THE IMPROVEMENT OF SUCH TREATMENT. TEACHING - ATTRACT, RECRUIT AND RETAIN WORLD CLASS CLINICAL, RESEARCH AND ACADEMIC EXPERTS IN THE AREA OF GLOBAL VASCULAR DISEASE AND RELATED NEUROLOGICAL DISEASES TO WESTERN NEW YORK: (1) TO BROADEN THE DEPTH OF TEACHING AT THE UNIVERSITY AT BUFFALO JACOBS SCHOOL OF MEDICINE AND BIOMEDICAL SCIENCES ("JACOBS SCHOOL OF MEDICINE") AND MAY, AMONG OTHER THINGS, CREATE ONE OR MORE TEACHING AND/OR ACADEMIC RESEARCH POSITIONS AT THE JACOBS SCHOOL OF MEDICINE OR OTHER 501(C)(3) INSTITUTIONS; AND (2) TO ESTABLISH WESTERN NEW YORK AS THE PRIMARY LOCATION FOR ACADEMIC COLLABORATION IN THE TREATMENT OF GLOBAL VASCULAR DISEASE AND RELATED NEUROLOGICAL DISEASES. PUBLIC AWARENESS - SPONSOR AND COORDINATE PUBLIC HEALTH INITIATIVES RAISING AWARENESS ABOUT VASCULAR DISEASE AND THE NEED FOR IMPROVED TREATMENT OF SUCH DISEASES. PROOF OF CONCEPT OF INNOVATIONS - VET INNOVATIONS IN CLINICAL CARE, ACADEMICS AND RESEARCH, RESULTING IN THE DEVELOPMENT OF NEW RESEARCH, CLINICAL CARE AND SPIN OFF ENTREPRENEURIAL DEVELOPMENTS AND JOBS IN WESTERN NEW YORK. REGULATORY SERVICES - PROVIDING EXPERTISE AND CONSULTING SERVICES IN DETERMINING HIGH-LEVEL STRATEGIES FOR: (1) MOVING MEDICAL DEVICES TO THE U.S. MARKETPLACE; (2) PREPARING FOR A U.S. FOOD &amp; DRUG ADMINISTRATION SUBMISSION; AND (3) CONDUCTING AN ASSESSMENT OF EARLY FEASIBILITY OF INITIATING A DEVICE STUDY IN THE U.S.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART VI, SECTION A, LINE 2</FormAndLineReferenceDesc>
        <ExplanationTxt>BOARD OF DIRECTORS HAVE BUSINESS RELATIONSHIPS WITH EACH OTHER IN THE NORMAL COURSE OF BUSINESS.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART VI, SECTION B, LINE 11B</FormAndLineReferenceDesc>
        <ExplanationTxt>DRAFT COPIES OF THE AUDITED CONSOLIDATED FINANCIAL STATEMENTS ARE REVIEWED BY THE JACOBS INSTITUTE'S AUDIT AND COMPLIANCE COMMITTEE. FOLLOWING ITS FINALIZATION, THE AUDITED CONSOLIDATED FINANCIAL STATEMENTS ARE DISTRIBUTED TO THE BOARD OF DIRECTORS. DRAFT COPIES OF THE 990 ARE REVIEWED PRIOR TO ITS FILING BY THE JACOBS INSTITUTE'S BOARD OF DIRECTORS.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART VI, SECTION B, LINE 12C</FormAndLineReferenceDesc>
        <ExplanationTxt>PRIOR TO THE BOARD OF DIRECTORS ANNUAL MEETING, A MEMORANDUM FROM THE JACOBS INSTITUTE, WHICH INCLUDES THE CONFLICT OF INTEREST POLICY, ALONG WITH A QUESTIONNAIRE, IS DISTRIBUTED TO THE BOARD OF DIRECTORS TO BE FILLED OUT AND COLLECTED BY THE SECRETARY. THE POLICY AND QUESTIONNAIRE ARE ALSO DISTRIBUTED TO JACOBS INSTITUTE EMPLOYEES AT THE SAME TIME, TO BE RETURNED TO THE COO/VP OF OPERATIONS. THE ANSWERS ARE COMPILED AND DISTRIBUTED TO THE BOARD OF DIRECTORS AT THE FOLLOWING BOARD MEETING.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART VI, SECTION B, LINE 15</FormAndLineReferenceDesc>
        <ExplanationTxt>COMPENSATION OF OFFICERS AND EMPLOYEES ARE REVIEWED BY INDEPENDENT PERSONS, AND FROM TIME TO TIME COMPARABILITY DATA IS USED TO HELP DETERMINE THE APPROPRIATENESS OF PROPOSED COMPENSATION LEVELS. TO DATE, THE PROCESS HAS INCLUDED DISCUSSIONS AMONG SENIOR MANAGEMENT (EXCLUDING ANYONE WITH A POTENTIAL CONFLICT OF INTEREST) FOLLOWED BY A DECISION TO SET COMPENSATION LEVELS. SALARY BENCHMARKING HAS ALSO BEEN USED IN CERTAIN CASES TO ESTABLISH OR SUBSTANTIATE APPROPRIATE SALARY LEVELS.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART VI, SECTION C, LINE 19</FormAndLineReferenceDesc>
        <ExplanationTxt>NO DOCUMENTS WERE MADE AVAILABLE TO THE PUBLIC DURING THE TAX YEAR.</ExplanationTxt>
      </SupplementalInformationDetail>
    </IRS990ScheduleO>
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        <RelatedOrganizationName>
          <BusinessNameLine1Txt>JI ECONOMIC DEVELOPMENT INITIATIVES INC</BusinessNameLine1Txt>
        </RelatedOrganizationName>
        <USAddress>
          <AddressLine1Txt>875 ELLICOTT ST FL 5TH</AddressLine1Txt>
          <CityNm>BUFFALO</CityNm>
          <StateAbbreviationCd>NY</StateAbbreviationCd>
          <ZIPCd>14203</ZIPCd>
        </USAddress>
        <EIN>863712817</EIN>
        <PrimaryActivitiesTxt>IDEA TO REALITY INNOVATION AND INCUBATION PROGRAM</PrimaryActivitiesTxt>
        <LegalDomicileStateCd>NY</LegalDomicileStateCd>
        <DirectControllingEntityName>
          <BusinessNameLine1Txt>THE JACOBS INSTITUTE INC</BusinessNameLine1Txt>
        </DirectControllingEntityName>
        <EntityTypeTxt>C</EntityTypeTxt>
        <OwnershipPct>1.00000</OwnershipPct>
        <ControlledOrganizationInd>0</ControlledOrganizationInd>
      </IdRelatedOrgTxblCorpTrGrp>
      <ReceiptOfIntAnntsRntsRyltsInd>0</ReceiptOfIntAnntsRntsRyltsInd>
      <GiftGrntOrCapContriToOthOrgInd>0</GiftGrntOrCapContriToOthOrgInd>
      <GiftGrntCapContriFromOthOrgInd>0</GiftGrntCapContriFromOthOrgInd>
      <LoansOrGuaranteesToOtherOrgInd>0</LoansOrGuaranteesToOtherOrgInd>
      <LoansOrGuaranteesFromOthOrgInd>0</LoansOrGuaranteesFromOthOrgInd>
      <DivRelatedOrganizationInd>0</DivRelatedOrganizationInd>
      <AssetSaleToOtherOrgInd>0</AssetSaleToOtherOrgInd>
      <AssetPurchaseFromOtherOrgInd>0</AssetPurchaseFromOtherOrgInd>
      <AssetExchangeInd>0</AssetExchangeInd>
      <RentalOfFacilitiesToOthOrgInd>0</RentalOfFacilitiesToOthOrgInd>
      <RentalOfFcltsFromOthOrgInd>0</RentalOfFcltsFromOthOrgInd>
      <PerformOfServicesForOthOrgInd>0</PerformOfServicesForOthOrgInd>
      <PerformOfServicesByOtherOrgInd>0</PerformOfServicesByOtherOrgInd>
      <SharingOfFacilitiesInd>0</SharingOfFacilitiesInd>
      <PaidEmployeesSharingInd>0</PaidEmployeesSharingInd>
      <ReimbursementPaidToOtherOrgInd>0</ReimbursementPaidToOtherOrgInd>
      <ReimbursementPaidByOtherOrgInd>0</ReimbursementPaidByOtherOrgInd>
      <TransferToOtherOrgInd>0</TransferToOtherOrgInd>
      <TransferFromOtherOrgInd>0</TransferFromOtherOrgInd>
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</Return>
