<?xml version="1.0" encoding="utf-8"?>
<Return xmlns="http://www.irs.gov/efile" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" returnVersion="2021v4.0">
  <ReturnHeader binaryAttachmentCnt="0">
    <ReturnTs>2022-11-09T14:44:26-05:00</ReturnTs>
    <TaxPeriodEndDt>2021-12-31</TaxPeriodEndDt>
    <PreparerFirmGrp>
      <PreparerFirmEIN>800955974</PreparerFirmEIN>
      <PreparerFirmName>
        <BusinessNameLine1Txt>ROZOVICS GROUP LLP</BusinessNameLine1Txt>
      </PreparerFirmName>
      <PreparerUSAddress>
        <AddressLine1Txt>1580 N NORTHWEST HWY STE 120</AddressLine1Txt>
        <CityNm>PARK RIDGE</CityNm>
        <StateAbbreviationCd>IL</StateAbbreviationCd>
        <ZIPCd>600681468</ZIPCd>
      </PreparerUSAddress>
    </PreparerFirmGrp>
    <ReturnTypeCd>990</ReturnTypeCd>
    <TaxPeriodBeginDt>2021-01-01</TaxPeriodBeginDt>
    <Filer>
      <EIN>562455310</EIN>
      <BusinessName>
        <BusinessNameLine1Txt>TWO BLADES FOUNDATION</BusinessNameLine1Txt>
      </BusinessName>
      <BusinessNameControlTxt>TWOB</BusinessNameControlTxt>
      <PhoneNum>8474251277</PhoneNum>
      <USAddress>
        <AddressLine1Txt>1630 CHICAGO AVENUE SUITE 1312</AddressLine1Txt>
        <CityNm>EVANSTON</CityNm>
        <StateAbbreviationCd>IL</StateAbbreviationCd>
        <ZIPCd>60201</ZIPCd>
      </USAddress>
    </Filer>
    <BusinessOfficerGrp>
      <PersonNm>DIANA M HORVATH</PersonNm>
      <PersonTitleTxt>PRESIDENT</PersonTitleTxt>
      <PhoneNum>8474251277</PhoneNum>
      <SignatureDt>2022-08-25</SignatureDt>
      <DiscussWithPaidPreparerInd>true</DiscussWithPaidPreparerInd>
    </BusinessOfficerGrp>
    <SigningOfficerGrp>
      <PersonFullName>
        <PersonFirstNm>DIANA</PersonFirstNm>
        <PersonLastNm>HORVATH</PersonLastNm>
      </PersonFullName>
      <SSN>XXX-XX-XXXX</SSN>
    </SigningOfficerGrp>
    <PreparerPersonGrp>
      <PreparerPersonNm>SUSAN M HUIZINGA</PreparerPersonNm>
      <PTIN>P01216560</PTIN>
      <PhoneNum>8476997600</PhoneNum>
      <PreparationDt>2022-11-09</PreparationDt>
    </PreparerPersonGrp>
    <TaxYr>2021</TaxYr>
    <BuildTS>2022-09-23 18:48:47Z</BuildTS>
  </ReturnHeader>
  <ReturnData documentCnt="8">
    <IRS990 documentId="RetDoc2" referenceDocumentId="RetDoc6">
      <PrincipalOfficerNm>DIANA M HORVATH</PrincipalOfficerNm>
      <USAddress>
        <AddressLine1Txt>1630 CHICAGO AVENUE SUITE1312</AddressLine1Txt>
        <CityNm>EVANSTON</CityNm>
        <StateAbbreviationCd>IL</StateAbbreviationCd>
        <ZIPCd>60201</ZIPCd>
      </USAddress>
      <GrossReceiptsAmt>5910316</GrossReceiptsAmt>
      <GroupReturnForAffiliatesInd>false</GroupReturnForAffiliatesInd>
      <Organization501c3Ind>X</Organization501c3Ind>
      <WebsiteAddressTxt>2BLADES.ORG</WebsiteAddressTxt>
      <TypeOfOrganizationCorpInd>X</TypeOfOrganizationCorpInd>
      <FormationYr>2004</FormationYr>
      <LegalDomicileStateCd>DE</LegalDomicileStateCd>
      <ActivityOrMissionDesc>SCIENTIFIC, RESEARCH AND EDUCATION</ActivityOrMissionDesc>
      <VotingMembersGoverningBodyCnt>5</VotingMembersGoverningBodyCnt>
      <VotingMembersIndependentCnt>2</VotingMembersIndependentCnt>
      <TotalEmployeeCnt>3</TotalEmployeeCnt>
      <TotalGrossUBIAmt>0</TotalGrossUBIAmt>
      <PYContributionsGrantsAmt>8537651</PYContributionsGrantsAmt>
      <CYContributionsGrantsAmt>5891399</CYContributionsGrantsAmt>
      <CYProgramServiceRevenueAmt>0</CYProgramServiceRevenueAmt>
      <PYInvestmentIncomeAmt>379</PYInvestmentIncomeAmt>
      <CYInvestmentIncomeAmt>18917</CYInvestmentIncomeAmt>
      <CYOtherRevenueAmt>0</CYOtherRevenueAmt>
      <PYTotalRevenueAmt>8538030</PYTotalRevenueAmt>
      <CYTotalRevenueAmt>5910316</CYTotalRevenueAmt>
      <PYGrantsAndSimilarPaidAmt>4360547</PYGrantsAndSimilarPaidAmt>
      <CYGrantsAndSimilarPaidAmt>4534055</CYGrantsAndSimilarPaidAmt>
      <CYBenefitsPaidToMembersAmt>0</CYBenefitsPaidToMembersAmt>
      <PYSalariesCompEmpBnftPaidAmt>825890</PYSalariesCompEmpBnftPaidAmt>
      <CYSalariesCompEmpBnftPaidAmt>752612</CYSalariesCompEmpBnftPaidAmt>
      <CYTotalProfFndrsngExpnsAmt>0</CYTotalProfFndrsngExpnsAmt>
      <CYTotalFundraisingExpenseAmt>451403</CYTotalFundraisingExpenseAmt>
      <PYOtherExpensesAmt>1443372</PYOtherExpensesAmt>
      <CYOtherExpensesAmt>1630817</CYOtherExpensesAmt>
      <PYTotalExpensesAmt>6629809</PYTotalExpensesAmt>
      <CYTotalExpensesAmt>6917484</CYTotalExpensesAmt>
      <PYRevenuesLessExpensesAmt>1908221</PYRevenuesLessExpensesAmt>
      <CYRevenuesLessExpensesAmt>-1007168</CYRevenuesLessExpensesAmt>
      <TotalAssetsBOYAmt>17604907</TotalAssetsBOYAmt>
      <TotalAssetsEOYAmt>11973096</TotalAssetsEOYAmt>
      <TotalLiabilitiesBOYAmt>8585058</TotalLiabilitiesBOYAmt>
      <TotalLiabilitiesEOYAmt>3960415</TotalLiabilitiesEOYAmt>
      <NetAssetsOrFundBalancesBOYAmt>9019849</NetAssetsOrFundBalancesBOYAmt>
      <NetAssetsOrFundBalancesEOYAmt>8012681</NetAssetsOrFundBalancesEOYAmt>
      <MissionDesc>SCIENTIFIC, RESEARCH AND EDUCATION</MissionDesc>
      <SignificantNewProgramSrvcInd>false</SignificantNewProgramSrvcInd>
      <SignificantChangeInd>false</SignificantChangeInd>
      <ExpenseAmt>6216891</ExpenseAmt>
      <GrantAmt>4534055</GrantAmt>
      <Desc>TWO BLADES SUPPORTS AND MANAGES PROGRAMS THAT ADVANCE SCIENTIFIC DISCOVERIES INTO PRACTICAL APPLICATIONS. TWO BLADES MANAGES A PORTFOLIO OF OWNED OR IN-LICENSED TECHNOLOGIES EMCOMPASSING SPECIFIC TRAITS AND ENABLING TECHNOLOGIES TO FIGHT PLANT DISEASE. TWO BLADES PAYS PATENT COSTS IN SUPPORT OF RESEARCH AND LICENSING AND PURSUES BUSINESS PARTNERS FOR DEVELOPMENT OF DISEASE RESISTANT PRODUCTS. IT ALSO MEETS WITH POTENTIAL PARTNER FOUNDATIONS TO DISCUSS CO-FUNDING OPPORTUNITIES. IT AWARDS RESEARCH GRANTS.</Desc>
      <TotalProgramServiceExpensesAmt>6216891</TotalProgramServiceExpensesAmt>
      <DescribedInSection501c3Ind referenceDocumentId="RetDoc7">true</DescribedInSection501c3Ind>
      <ScheduleBRequiredInd referenceDocumentId="RetDoc1">true</ScheduleBRequiredInd>
      <PoliticalCampaignActyInd>false</PoliticalCampaignActyInd>
      <LobbyingActivitiesInd>false</LobbyingActivitiesInd>
      <SubjectToProxyTaxInd>false</SubjectToProxyTaxInd>
      <DonorAdvisedFundInd referenceDocumentId="RetDoc3">false</DonorAdvisedFundInd>
      <ConservationEasementsInd referenceDocumentId="RetDoc3">false</ConservationEasementsInd>
      <CollectionsOfArtInd referenceDocumentId="RetDoc3">false</CollectionsOfArtInd>
      <CreditCounselingInd referenceDocumentId="RetDoc3">false</CreditCounselingInd>
      <DonorRstrOrQuasiEndowmentsInd referenceDocumentId="RetDoc3">false</DonorRstrOrQuasiEndowmentsInd>
      <ReportLandBuildingEquipmentInd referenceDocumentId="RetDoc3">false</ReportLandBuildingEquipmentInd>
      <ReportInvestmentsOtherSecInd referenceDocumentId="RetDoc3">false</ReportInvestmentsOtherSecInd>
      <ReportProgramRelatedInvstInd referenceDocumentId="RetDoc3">false</ReportProgramRelatedInvstInd>
      <ReportOtherAssetsInd referenceDocumentId="RetDoc3">true</ReportOtherAssetsInd>
      <ReportOtherLiabilitiesInd referenceDocumentId="RetDoc3">false</ReportOtherLiabilitiesInd>
      <IncludeFIN48FootnoteInd referenceDocumentId="RetDoc3">false</IncludeFIN48FootnoteInd>
      <IndependentAuditFinclStmtInd referenceDocumentId="RetDoc3">true</IndependentAuditFinclStmtInd>
      <ConsolidatedAuditFinclStmtInd referenceDocumentId="RetDoc3">false</ConsolidatedAuditFinclStmtInd>
      <SchoolOperatingInd>false</SchoolOperatingInd>
      <ForeignOfficeInd>false</ForeignOfficeInd>
      <ForeignActivitiesInd referenceDocumentId="RetDoc8">false</ForeignActivitiesInd>
      <MoreThan5000KToOrgInd referenceDocumentId="RetDoc8">true</MoreThan5000KToOrgInd>
      <MoreThan5000KToIndividualsInd referenceDocumentId="RetDoc8">false</MoreThan5000KToIndividualsInd>
      <ProfessionalFundraisingInd>false</ProfessionalFundraisingInd>
      <FundraisingActivitiesInd>false</FundraisingActivitiesInd>
      <GamingActivitiesInd>false</GamingActivitiesInd>
      <OperateHospitalInd>false</OperateHospitalInd>
      <GrantsToOrganizationsInd referenceDocumentId="RetDoc4">true</GrantsToOrganizationsInd>
      <GrantsToIndividualsInd referenceDocumentId="RetDoc4">false</GrantsToIndividualsInd>
      <ScheduleJRequiredInd referenceDocumentId="RetDoc5">true</ScheduleJRequiredInd>
      <TaxExemptBondsInd>false</TaxExemptBondsInd>
      <EngagedInExcessBenefitTransInd>false</EngagedInExcessBenefitTransInd>
      <PYExcessBenefitTransInd>false</PYExcessBenefitTransInd>
      <LoanOutstandingInd>false</LoanOutstandingInd>
      <GrantToRelatedPersonInd>false</GrantToRelatedPersonInd>
      <BusinessRlnWithOrgMemInd>false</BusinessRlnWithOrgMemInd>
      <BusinessRlnWithFamMemInd>false</BusinessRlnWithFamMemInd>
      <BusinessRlnWith35CtrlEntInd>false</BusinessRlnWith35CtrlEntInd>
      <DeductibleNonCashContriInd>false</DeductibleNonCashContriInd>
      <DeductibleArtContributionInd>false</DeductibleArtContributionInd>
      <TerminateOperationsInd>false</TerminateOperationsInd>
      <PartialLiquidationInd>false</PartialLiquidationInd>
      <DisregardedEntityInd>false</DisregardedEntityInd>
      <RelatedEntityInd>false</RelatedEntityInd>
      <RelatedOrganizationCtrlEntInd>false</RelatedOrganizationCtrlEntInd>
      <TrnsfrExmptNonChrtblRltdOrgInd>false</TrnsfrExmptNonChrtblRltdOrgInd>
      <ActivitiesConductedPrtshpInd>false</ActivitiesConductedPrtshpInd>
      <ScheduleORequiredInd>true</ScheduleORequiredInd>
      <IRPDocumentCnt>1</IRPDocumentCnt>
      <IRPDocumentW2GCnt>0</IRPDocumentW2GCnt>
      <BackupWthldComplianceInd>false</BackupWthldComplianceInd>
      <EmployeeCnt>3</EmployeeCnt>
      <EmploymentTaxReturnsFiledInd>true</EmploymentTaxReturnsFiledInd>
      <UnrelatedBusIncmOverLimitInd>false</UnrelatedBusIncmOverLimitInd>
      <ForeignFinancialAccountInd>false</ForeignFinancialAccountInd>
      <ProhibitedTaxShelterTransInd>false</ProhibitedTaxShelterTransInd>
      <TaxablePartyNotificationInd>false</TaxablePartyNotificationInd>
      <NondeductibleContributionsInd>false</NondeductibleContributionsInd>
      <IndoorTanningServicesInd>false</IndoorTanningServicesInd>
      <SubjToTaxRmnrtnExPrchtPymtInd>false</SubjToTaxRmnrtnExPrchtPymtInd>
      <SubjectToExcsTaxNetInvstIncInd>false</SubjectToExcsTaxNetInvstIncInd>
      <InfoInScheduleOPartVIInd>X</InfoInScheduleOPartVIInd>
      <GoverningBodyVotingMembersCnt>5</GoverningBodyVotingMembersCnt>
      <IndependentVotingMemberCnt>2</IndependentVotingMemberCnt>
      <FamilyOrBusinessRlnInd>false</FamilyOrBusinessRlnInd>
      <DelegationOfMgmtDutiesInd>false</DelegationOfMgmtDutiesInd>
      <ChangeToOrgDocumentsInd>false</ChangeToOrgDocumentsInd>
      <MaterialDiversionOrMisuseInd>false</MaterialDiversionOrMisuseInd>
      <MembersOrStockholdersInd>false</MembersOrStockholdersInd>
      <ElectionOfBoardMembersInd>false</ElectionOfBoardMembersInd>
      <DecisionsSubjectToApprovaInd>false</DecisionsSubjectToApprovaInd>
      <MinutesOfGoverningBodyInd>true</MinutesOfGoverningBodyInd>
      <MinutesOfCommitteesInd>true</MinutesOfCommitteesInd>
      <OfficerMailingAddressInd>false</OfficerMailingAddressInd>
      <LocalChaptersInd>false</LocalChaptersInd>
      <Form990ProvidedToGvrnBodyInd>false</Form990ProvidedToGvrnBodyInd>
      <ConflictOfInterestPolicyInd>true</ConflictOfInterestPolicyInd>
      <AnnualDisclosureCoveredPrsnInd>true</AnnualDisclosureCoveredPrsnInd>
      <RegularMonitoringEnfrcInd>false</RegularMonitoringEnfrcInd>
      <WhistleblowerPolicyInd>true</WhistleblowerPolicyInd>
      <DocumentRetentionPolicyInd>false</DocumentRetentionPolicyInd>
      <CompensationProcessCEOInd>false</CompensationProcessCEOInd>
      <CompensationProcessOtherInd>false</CompensationProcessOtherInd>
      <InvestmentInJointVentureInd>false</InvestmentInJointVentureInd>
      <StatesWhereCopyOfReturnIsFldCd>IL</StatesWhereCopyOfReturnIsFldCd>
      <UponRequestInd>X</UponRequestInd>
      <BooksInCareOfDetail>
        <PersonNm>DIANA M HORVATH</PersonNm>
        <PhoneNum>8474251277</PhoneNum>
        <USAddress>
          <AddressLine1Txt>1630 CHICAGO AVENUE SUITE1312</AddressLine1Txt>
          <CityNm>EVANSTON</CityNm>
          <StateAbbreviationCd>IL</StateAbbreviationCd>
          <ZIPCd>60201</ZIPCd>
        </USAddress>
      </BooksInCareOfDetail>
      <Form990PartVIISectionAGrp>
        <PersonNm>DIANA M HORVATH</PersonNm>
        <TitleTxt>PRESIDENT</TitleTxt>
        <AverageHoursPerWeekRt>40.00</AverageHoursPerWeekRt>
        <IndividualTrusteeOrDirectorInd>X</IndividualTrusteeOrDirectorInd>
        <OfficerInd>X</OfficerInd>
        <ReportableCompFromOrgAmt>276770</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>26451</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>ROGER FREEDMAN</PersonNm>
        <TitleTxt>CHAIRMAN</TitleTxt>
        <IndividualTrusteeOrDirectorInd>X</IndividualTrusteeOrDirectorInd>
        <ReportableCompFromOrgAmt>0</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>0</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>ROB HORSCH</PersonNm>
        <TitleTxt>DIRECTOR</TitleTxt>
        <IndividualTrusteeOrDirectorInd>X</IndividualTrusteeOrDirectorInd>
        <ReportableCompFromOrgAmt>0</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>0</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>ERIC WARD</PersonNm>
        <TitleTxt>DIRECTOR</TitleTxt>
        <IndividualTrusteeOrDirectorInd>X</IndividualTrusteeOrDirectorInd>
        <ReportableCompFromOrgAmt>0</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>0</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <Form990PartVIISectionAGrp>
        <PersonNm>PETER VANESSE</PersonNm>
        <TitleTxt>VICE PRESIDE</TitleTxt>
        <IndividualTrusteeOrDirectorInd>X</IndividualTrusteeOrDirectorInd>
        <ReportableCompFromOrgAmt>0</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>0</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <TotalReportableCompFromOrgAmt>276770</TotalReportableCompFromOrgAmt>
      <TotalOtherCompensationAmt>26451</TotalOtherCompensationAmt>
      <IndivRcvdGreaterThan100KCnt>1</IndivRcvdGreaterThan100KCnt>
      <FormerOfcrEmployeesListedInd>false</FormerOfcrEmployeesListedInd>
      <TotalCompGreaterThan150KInd>true</TotalCompGreaterThan150KInd>
      <CompensationFromOtherSrcsInd>false</CompensationFromOtherSrcsInd>
      <GovernmentGrantsAmt>185000</GovernmentGrantsAmt>
      <AllOtherContributionsAmt>5706399</AllOtherContributionsAmt>
      <TotalContributionsAmt>5891399</TotalContributionsAmt>
      <InvestmentIncomeGrp>
        <TotalRevenueColumnAmt>18917</TotalRevenueColumnAmt>
        <RelatedOrExemptFuncIncomeAmt>18917</RelatedOrExemptFuncIncomeAmt>
      </InvestmentIncomeGrp>
      <TotalRevenueGrp>
        <TotalRevenueColumnAmt>5910316</TotalRevenueColumnAmt>
        <RelatedOrExemptFuncIncomeAmt>18917</RelatedOrExemptFuncIncomeAmt>
      </TotalRevenueGrp>
      <GrantsToDomesticOrgsGrp>
        <TotalAmt>457514</TotalAmt>
        <ProgramServicesAmt>457514</ProgramServicesAmt>
      </GrantsToDomesticOrgsGrp>
      <ForeignGrantsGrp>
        <TotalAmt>4076541</TotalAmt>
        <ProgramServicesAmt>4076541</ProgramServicesAmt>
      </ForeignGrantsGrp>
      <OtherSalariesAndWagesGrp>
        <TotalAmt>654883</TotalAmt>
        <ProgramServicesAmt>223342</ProgramServicesAmt>
        <ManagementAndGeneralAmt>155869</ManagementAndGeneralAmt>
        <FundraisingAmt>275672</FundraisingAmt>
      </OtherSalariesAndWagesGrp>
      <PensionPlanContributionsGrp>
        <TotalAmt>61392</TotalAmt>
        <ProgramServicesAmt>20937</ProgramServicesAmt>
        <ManagementAndGeneralAmt>14612</ManagementAndGeneralAmt>
        <FundraisingAmt>25843</FundraisingAmt>
      </PensionPlanContributionsGrp>
      <PayrollTaxesGrp>
        <TotalAmt>36337</TotalAmt>
        <ProgramServicesAmt>12392</ProgramServicesAmt>
        <ManagementAndGeneralAmt>8649</ManagementAndGeneralAmt>
        <FundraisingAmt>15296</FundraisingAmt>
      </PayrollTaxesGrp>
      <FeesForServicesLegalGrp>
        <TotalAmt>70153</TotalAmt>
        <ProgramServicesAmt>68378</ProgramServicesAmt>
        <ManagementAndGeneralAmt>1775</ManagementAndGeneralAmt>
      </FeesForServicesLegalGrp>
      <FeesForServicesAccountingGrp>
        <TotalAmt>9998</TotalAmt>
        <ManagementAndGeneralAmt>9998</ManagementAndGeneralAmt>
      </FeesForServicesAccountingGrp>
      <FeesForServicesOtherGrp>
        <TotalAmt>25</TotalAmt>
        <ManagementAndGeneralAmt>25</ManagementAndGeneralAmt>
      </FeesForServicesOtherGrp>
      <AdvertisingGrp>
        <TotalAmt>112133</TotalAmt>
        <FundraisingAmt>112133</FundraisingAmt>
      </AdvertisingGrp>
      <OfficeExpensesGrp>
        <TotalAmt>9463</TotalAmt>
        <ProgramServicesAmt>3202</ProgramServicesAmt>
        <ManagementAndGeneralAmt>2309</ManagementAndGeneralAmt>
        <FundraisingAmt>3952</FundraisingAmt>
      </OfficeExpensesGrp>
      <OccupancyGrp>
        <TotalAmt>49160</TotalAmt>
        <ProgramServicesAmt>26074</ProgramServicesAmt>
        <ManagementAndGeneralAmt>18197</ManagementAndGeneralAmt>
        <FundraisingAmt>4889</FundraisingAmt>
      </OccupancyGrp>
      <TravelGrp>
        <TotalAmt>9372</TotalAmt>
        <ProgramServicesAmt>3280</ProgramServicesAmt>
        <ManagementAndGeneralAmt>3280</ManagementAndGeneralAmt>
        <FundraisingAmt>2812</FundraisingAmt>
      </TravelGrp>
      <ConferencesMeetingsGrp>
        <TotalAmt>476</TotalAmt>
        <ProgramServicesAmt>476</ProgramServicesAmt>
      </ConferencesMeetingsGrp>
      <InsuranceGrp>
        <TotalAmt>40000</TotalAmt>
        <ProgramServicesAmt>18759</ProgramServicesAmt>
        <ManagementAndGeneralAmt>13092</ManagementAndGeneralAmt>
        <FundraisingAmt>8149</FundraisingAmt>
      </InsuranceGrp>
      <OtherExpensesGrp>
        <Desc>PATENT MAINTENANCE</Desc>
        <TotalAmt>603193</TotalAmt>
        <ProgramServicesAmt>603193</ProgramServicesAmt>
      </OtherExpensesGrp>
      <OtherExpensesGrp>
        <Desc>RESEARCH-DEVELOPMENT</Desc>
        <TotalAmt>529209</TotalAmt>
        <ProgramServicesAmt>529209</ProgramServicesAmt>
      </OtherExpensesGrp>
      <OtherExpensesGrp>
        <Desc>LICENSE EXPENSES</Desc>
        <TotalAmt>107328</TotalAmt>
        <ProgramServicesAmt>107328</ProgramServicesAmt>
      </OtherExpensesGrp>
      <OtherExpensesGrp>
        <Desc>REALIZED LOSS FOREIGN X</Desc>
        <TotalAmt>101498</TotalAmt>
        <ProgramServicesAmt>101498</ProgramServicesAmt>
      </OtherExpensesGrp>
      <AllOtherExpensesGrp>
        <TotalAmt>-11191</TotalAmt>
        <ProgramServicesAmt>-35232</ProgramServicesAmt>
        <ManagementAndGeneralAmt>21384</ManagementAndGeneralAmt>
        <FundraisingAmt>2657</FundraisingAmt>
      </AllOtherExpensesGrp>
      <TotalFunctionalExpensesGrp>
        <TotalAmt>6917484</TotalAmt>
        <ProgramServicesAmt>6216891</ProgramServicesAmt>
        <ManagementAndGeneralAmt>249190</ManagementAndGeneralAmt>
        <FundraisingAmt>451403</FundraisingAmt>
      </TotalFunctionalExpensesGrp>
      <CashNonInterestBearingGrp>
        <BOYAmt>9406458</BOYAmt>
        <EOYAmt>8185586</EOYAmt>
      </CashNonInterestBearingGrp>
      <AccountsReceivableGrp>
        <BOYAmt>24747</BOYAmt>
        <EOYAmt>147863</EOYAmt>
      </AccountsReceivableGrp>
      <OtherAssetsTotalGrp>
        <BOYAmt>8173702</BOYAmt>
        <EOYAmt>3639647</EOYAmt>
      </OtherAssetsTotalGrp>
      <TotalAssetsGrp>
        <BOYAmt>17604907</BOYAmt>
        <EOYAmt>11973096</EOYAmt>
      </TotalAssetsGrp>
      <AccountsPayableAccrExpnssGrp>
        <BOYAmt>56126</BOYAmt>
        <EOYAmt>56831</EOYAmt>
      </AccountsPayableAccrExpnssGrp>
      <GrantsPayableGrp>
        <BOYAmt>8528932</BOYAmt>
        <EOYAmt>3903584</EOYAmt>
      </GrantsPayableGrp>
      <TotalLiabilitiesGrp>
        <BOYAmt>8585058</BOYAmt>
        <EOYAmt>3960415</EOYAmt>
      </TotalLiabilitiesGrp>
      <OrgDoesNotFollowFASB117Ind>X</OrgDoesNotFollowFASB117Ind>
      <RtnEarnEndowmentIncmOthFndsGrp>
        <BOYAmt>9019849</BOYAmt>
        <EOYAmt>8012681</EOYAmt>
      </RtnEarnEndowmentIncmOthFndsGrp>
      <TotalNetAssetsFundBalanceGrp>
        <BOYAmt>9019849</BOYAmt>
        <EOYAmt>8012681</EOYAmt>
      </TotalNetAssetsFundBalanceGrp>
      <TotLiabNetAssetsFundBalanceGrp>
        <BOYAmt>17604907</BOYAmt>
        <EOYAmt>11973096</EOYAmt>
      </TotLiabNetAssetsFundBalanceGrp>
      <ReconcilationRevenueExpnssAmt>-1007168</ReconcilationRevenueExpnssAmt>
      <MethodOfAccountingAccrualInd>X</MethodOfAccountingAccrualInd>
      <AccountantCompileOrReviewInd>false</AccountantCompileOrReviewInd>
      <FSAuditedInd>false</FSAuditedInd>
    </IRS990>
    <IRS990ScheduleA documentId="RetDoc7">
      <PubliclySupportedOrg509a2Ind>X</PubliclySupportedOrg509a2Ind>
      <GiftsGrantsContrisRcvd509Grp>
        <CurrentTaxYearMinus4YearsAmt>8976959</CurrentTaxYearMinus4YearsAmt>
        <CurrentTaxYearMinus3YearsAmt>7432713</CurrentTaxYearMinus3YearsAmt>
        <CurrentTaxYearMinus2YearsAmt>5870596</CurrentTaxYearMinus2YearsAmt>
        <CurrentTaxYearMinus1YearAmt>8537651</CurrentTaxYearMinus1YearAmt>
        <CurrentTaxYearAmt>5891399</CurrentTaxYearAmt>
        <TotalAmt>36709318</TotalAmt>
      </GiftsGrantsContrisRcvd509Grp>
      <GrossReceiptsAdmissionsGrp>
        <CurrentTaxYearMinus1YearAmt>379</CurrentTaxYearMinus1YearAmt>
        <CurrentTaxYearAmt>18917</CurrentTaxYearAmt>
        <TotalAmt>19296</TotalAmt>
      </GrossReceiptsAdmissionsGrp>
      <Total509Grp>
        <CurrentTaxYearMinus4YearsAmt>8976959</CurrentTaxYearMinus4YearsAmt>
        <CurrentTaxYearMinus3YearsAmt>7432713</CurrentTaxYearMinus3YearsAmt>
        <CurrentTaxYearMinus2YearsAmt>5870596</CurrentTaxYearMinus2YearsAmt>
        <CurrentTaxYearMinus1YearAmt>8538030</CurrentTaxYearMinus1YearAmt>
        <CurrentTaxYearAmt>5910316</CurrentTaxYearAmt>
        <TotalAmt>36728614</TotalAmt>
      </Total509Grp>
      <PublicSupportTotal509Amt>36728614</PublicSupportTotal509Amt>
      <GrossInvestmentIncome509Grp>
        <CurrentTaxYearMinus4YearsAmt>1082</CurrentTaxYearMinus4YearsAmt>
        <CurrentTaxYearMinus3YearsAmt>2229</CurrentTaxYearMinus3YearsAmt>
        <CurrentTaxYearMinus2YearsAmt>3680</CurrentTaxYearMinus2YearsAmt>
        <TotalAmt>6991</TotalAmt>
      </GrossInvestmentIncome509Grp>
      <InvestmentIncomeAndUBTIGrp>
        <CurrentTaxYearMinus4YearsAmt>1082</CurrentTaxYearMinus4YearsAmt>
        <CurrentTaxYearMinus3YearsAmt>2229</CurrentTaxYearMinus3YearsAmt>
        <CurrentTaxYearMinus2YearsAmt>3680</CurrentTaxYearMinus2YearsAmt>
        <TotalAmt>6991</TotalAmt>
      </InvestmentIncomeAndUBTIGrp>
      <TotalSupportCalendarYearGrp>
        <CurrentTaxYearMinus4YearsAmt>8978041</CurrentTaxYearMinus4YearsAmt>
        <CurrentTaxYearMinus3YearsAmt>7434942</CurrentTaxYearMinus3YearsAmt>
        <CurrentTaxYearMinus2YearsAmt>5874276</CurrentTaxYearMinus2YearsAmt>
        <CurrentTaxYearMinus1YearAmt>8538030</CurrentTaxYearMinus1YearAmt>
        <CurrentTaxYearAmt>5910316</CurrentTaxYearAmt>
        <TotalAmt>36735605</TotalAmt>
      </TotalSupportCalendarYearGrp>
      <PublicSupportCY509Pct>0.99980</PublicSupportCY509Pct>
      <PublicSupportPY509Pct>0.99980</PublicSupportPY509Pct>
      <InvestmentIncomeCYPct>0.00000</InvestmentIncomeCYPct>
      <InvestmentIncomePYPct>0.00000</InvestmentIncomePYPct>
      <ThirtyThrPctSuprtTestsCY509Ind>X</ThirtyThrPctSuprtTestsCY509Ind>
    </IRS990ScheduleA>
    <IRS990ScheduleB documentId="RetDoc1">
      <ContributorInformationGrp>
        <ContributorNum>RESTRICTED</ContributorNum>
        <ContributorBusinessName>
          <BusinessNameLine1>RESTRICTED</BusinessNameLine1>
        </ContributorBusinessName>
        <ContributorUSAddress>
          <AddressLine1>RESTRICTED</AddressLine1>
          <AddressLine2>RESTRICTED</AddressLine2>
          <City>RESTRICTED</City>
          <State>RESTRICTED</State>
          <ZIPCode>RESTRICTED</ZIPCode>
        </ContributorUSAddress>
        <TotalContributionsAmt>RESTRICTED</TotalContributionsAmt>
      </ContributorInformationGrp>
    </IRS990ScheduleB>
    <IRS990ScheduleD documentId="RetDoc3">
      <OtherAssetsOrgGrp>
        <Desc>DEFERRED SPONSORED RESEARCH</Desc>
        <BookValueAmt>3639647</BookValueAmt>
      </OtherAssetsOrgGrp>
      <TotalBookValueOtherAssetsAmt>3639647</TotalBookValueOtherAssetsAmt>
      <TotalRevEtcAuditedFinclStmtAmt>5910316</TotalRevEtcAuditedFinclStmtAmt>
      <RevenueSubtotalAmt>5910316</RevenueSubtotalAmt>
      <TotalRevenuePerForm990Amt>5910316</TotalRevenuePerForm990Amt>
      <TotExpnsEtcAuditedFinclStmtAmt>6917484</TotExpnsEtcAuditedFinclStmtAmt>
      <ExpensesSubtotalAmt>6917484</ExpensesSubtotalAmt>
      <TotalExpensesPerForm990Amt>6917484</TotalExpensesPerForm990Amt>
    </IRS990ScheduleD>
    <IRS990ScheduleF documentId="RetDoc8">
      <GrantsToOrgOutsideUSGrp>
        <RegionTxt>UNITED KINGDOM</RegionTxt>
        <PurposeOfGrantTxt>RESEARCH</PurposeOfGrantTxt>
        <CashGrantAmt>1760045</CashGrantAmt>
        <MannerOfCashDisbursementTxt>WIRE TRANSFER</MannerOfCashDisbursementTxt>
        <ValuationMethodUsedDesc>US DOLLARS</ValuationMethodUsedDesc>
      </GrantsToOrgOutsideUSGrp>
      <GrantsToOrgOutsideUSGrp>
        <RegionTxt>AUSTRALIA</RegionTxt>
        <PurposeOfGrantTxt>RESEARCH</PurposeOfGrantTxt>
        <CashGrantAmt>413936</CashGrantAmt>
        <MannerOfCashDisbursementTxt>WIRE TRANSFER</MannerOfCashDisbursementTxt>
        <ValuationMethodUsedDesc>US DOLLARS</ValuationMethodUsedDesc>
      </GrantsToOrgOutsideUSGrp>
      <GrantsToOrgOutsideUSGrp>
        <RegionTxt>BRAZIL</RegionTxt>
        <PurposeOfGrantTxt>RESEARCH</PurposeOfGrantTxt>
        <CashGrantAmt>671106</CashGrantAmt>
        <MannerOfCashDisbursementTxt>WIRE TRANSFER</MannerOfCashDisbursementTxt>
        <ValuationMethodUsedDesc>US DOLLARS</ValuationMethodUsedDesc>
      </GrantsToOrgOutsideUSGrp>
      <GrantsToOrgOutsideUSGrp>
        <RegionTxt>UNITED KINGDOM</RegionTxt>
        <PurposeOfGrantTxt>RESEARCH</PurposeOfGrantTxt>
        <CashGrantAmt>1179046</CashGrantAmt>
        <MannerOfCashDisbursementTxt>WIRE TRANSFER</MannerOfCashDisbursementTxt>
        <ValuationMethodUsedDesc>US DOLLARS</ValuationMethodUsedDesc>
      </GrantsToOrgOutsideUSGrp>
      <GrantsToOrgOutsideUSGrp>
        <RegionTxt>SAUDI ARABIA</RegionTxt>
        <PurposeOfGrantTxt>RESEARCH</PurposeOfGrantTxt>
        <CashGrantAmt>52408</CashGrantAmt>
        <MannerOfCashDisbursementTxt>WIRE TRANSFER</MannerOfCashDisbursementTxt>
        <ValuationMethodUsedDesc>US DOLLARS</ValuationMethodUsedDesc>
      </GrantsToOrgOutsideUSGrp>
      <TransferToForeignCorpInd>false</TransferToForeignCorpInd>
      <InterestInForeignTrustInd>false</InterestInForeignTrustInd>
      <ForeignCorpOwnershipInd>false</ForeignCorpOwnershipInd>
      <PassiveForeignInvestmestCoInd>false</PassiveForeignInvestmestCoInd>
      <ForeignPartnershipInd>false</ForeignPartnershipInd>
      <BoycottCountriesInd>false</BoycottCountriesInd>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>SCHEDULE F, PAGE 1, PART I, LINE 2</FormAndLineReferenceDesc>
        <ExplanationTxt>THE GRANTEE REPORTS BACK TO THE GRANTOR THEIR PROGRESS AND FINDINGS. THERE IS A SIGNED CONTRACT.</ExplanationTxt>
      </SupplementalInformationDetail>
    </IRS990ScheduleF>
    <IRS990ScheduleI documentId="RetDoc4">
      <GrantRecordsMaintainedInd>false</GrantRecordsMaintainedInd>
      <RecipientTable>
        <RecipientBusinessName>
          <BusinessNameLine1Txt>UNIVERSITY OF CALIFORNIA</BusinessNameLine1Txt>
        </RecipientBusinessName>
        <USAddress>
          <AddressLine1Txt>241A KOSHLAND</AddressLine1Txt>
          <CityNm>BERKELEY</CityNm>
          <StateAbbreviationCd>CA</StateAbbreviationCd>
          <ZIPCd>94720</ZIPCd>
        </USAddress>
        <CashGrantAmt>300000</CashGrantAmt>
        <PurposeOfGrantTxt>RESEARCH</PurposeOfGrantTxt>
      </RecipientTable>
      <RecipientTable>
        <RecipientBusinessName>
          <BusinessNameLine1Txt>UNIVERSITY OF MINNESOTA</BusinessNameLine1Txt>
        </RecipientBusinessName>
        <USAddress>
          <AddressLine1Txt>NW 5957 PO BOX 1450</AddressLine1Txt>
          <CityNm>MINNEAPOLIS</CityNm>
          <StateAbbreviationCd>MN</StateAbbreviationCd>
          <ZIPCd>55485</ZIPCd>
        </USAddress>
        <CashGrantAmt>157514</CashGrantAmt>
        <PurposeOfGrantTxt>RESEARCH</PurposeOfGrantTxt>
      </RecipientTable>
    </IRS990ScheduleI>
    <IRS990ScheduleJ documentId="RetDoc5">
      <SeverancePaymentInd>false</SeverancePaymentInd>
      <SupplementalNonqualRtrPlanInd>false</SupplementalNonqualRtrPlanInd>
      <EquityBasedCompArrngmInd>false</EquityBasedCompArrngmInd>
      <CompBasedOnRevenueOfFlngOrgInd>false</CompBasedOnRevenueOfFlngOrgInd>
      <CompBsdOnRevRelatedOrgsInd>false</CompBsdOnRevRelatedOrgsInd>
      <CompBsdNetEarnsFlngOrgInd>false</CompBsdNetEarnsFlngOrgInd>
      <CompBsdNetEarnsRltdOrgsInd>false</CompBsdNetEarnsRltdOrgsInd>
      <AnyNonFixedPaymentsInd>false</AnyNonFixedPaymentsInd>
      <InitialContractExceptionInd>false</InitialContractExceptionInd>
      <RltdOrgOfficerTrstKeyEmplGrp>
        <PersonNm>DIANA M HORVATH</PersonNm>
        <TitleTxt>PRESIDENT</TitleTxt>
        <BaseCompensationFilingOrgAmt>276770</BaseCompensationFilingOrgAmt>
        <DeferredCompensationFlngOrgAmt>26451</DeferredCompensationFlngOrgAmt>
        <TotalCompensationFilingOrgAmt>303221</TotalCompensationFilingOrgAmt>
      </RltdOrgOfficerTrstKeyEmplGrp>
    </IRS990ScheduleJ>
    <IRS990ScheduleO documentId="RetDoc6">
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PAGE 6, PART VI, LINE 11B</FormAndLineReferenceDesc>
        <ExplanationTxt>50% OF THE BOARD OF DIRECTORS SIGN THE STATE RETURN WHICH HAS A COPY OF THIS 990 ATTACHED.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PAGE 6, PART VI, LINE 19</FormAndLineReferenceDesc>
        <ExplanationTxt>UPON WRITTEN REQUEST.</ExplanationTxt>
      </SupplementalInformationDetail>
    </IRS990ScheduleO>
  </ReturnData>
</Return>
