2022-08-08T16:44:10-05:00 2021-09-30 ERNST & YOUNG US LLP 18101 VON KARMAN AVE STE 1700 IRVINE CA 92612 990 2020-10-01 331092191 THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE FOUNDATION % TRACY KARNS TRAN 6023438411 445 N 5TH STREET Suite 120 PHOENIX AZ 85004 MANUEL ESTRADA CFO, TGEN 6023438478 2022-08-02 true Manuel Estrada 999009999 Kara Adams P00023315 9497942300 2022-08-04 3 2020 2022-09-23 18:48:47Z ERIN MASSEY 445 N 5TH STREET PHOENIX AZ 85004 3772453 false X WWW.TGEN.ORG/GIVING/TGEN-FOUNDATION/ X 2004 AZ BIOGENOMIC MEDICAL RESEARCH FUNDRAISING FOR THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (TGEN). 20 17 0 80 0 0 22935783 3753754 0 0 127078 18699 0 0 23062861 3772453 10593325 12765361 0 0 1330040 1204433 0 0 1328492 405501 272409 12328866 14242203 10733995 -10469750 36934555 24235369 10737751 8501445 26196804 15733924 X BIOGENOMICS MEDICAL RESEARCH FUNDRAISING FOR THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (TGEN). false false 12765361 12765361 0 SEE SCHEDULE O 12765361 true true false false false false false false false true false false false false false true false true false false false false false false false false false true false true false false false false false false false false true false false false false true true false false false true X 9 0 true 0 false false false false false true true false false false false false false X 20 17 true false false false true true true true true false false true true true true true true false false false X TRACY KARNS 6023438415 445 N 5TH STREET SUITE 600 PHOENIX AZ 85004 X JEFFREY M TRENT PHD BOARD MEMBER 1.0 39.0 X 0 1047178 249398 TERESA BURLESON BOARD MEMBER/ASST TREASURER 1.0 39.0 X X 0 873615 127378 ERIN MASSEY CHIEF DEVELOPMENT OFFICER 40.0 0.0 X 0 408639 15781 MANUEL ESTRADA CHIEF FINANCIAL OFFICER 1.0 39.0 X 0 352079 21354 RICHARD J LEHMANN BOARD MEMBER/TREASURER 1.0 0.0 X X 0 0 0 BENNETT DORRANCE BOARD MEMBER/CHAIRMAN 1.0 1.0 X X 0 0 0 PHIL FRANCIS BOARD MEMBER 1.0 0.0 X 0 0 0 STEVE HILTON BOARD MEMBER 1.0 0.0 X 0 0 0 CARRIE HULBURD BOARD MEMBER 1.0 0.0 X 0 0 0 MIKE INGRAM BOARD MEMBER 1.0 0.0 X 0 0 0 CATHERINE IVY BOARD MEMBER 1.0 0.0 X 0 0 0 MICHEAL KAPLAN BOARD MEMBER 1.0 0.0 X 0 0 0 KEN KENDRICK BOARD MEMBER 1.0 0.0 X 0 0 0 DAVID LANE BOARD MEMBER 1.0 0.0 X 0 0 0 Terry Lee Board member (PT YR) 1.0 1.0 X 0 0 0 RANDY MAY BOARD MEMBER 1.0 0.0 X 0 0 0 ARTE MORENO BOARD MEMBER 1.0 0.0 X 0 0 0 BILL POPE BOARD MEMBER 1.0 0.0 X 0 0 0 WILLIAM J POST BOARD MEMBER 1.0 0.0 X 0 0 0 J DANFORTH QUAYLE BOARD MEMBER 1.0 0.0 X 0 0 0 TROY RICHARDS BOARD MEMBER 1.0 0.0 X 0 0 0 STEVE STAGNER BOARD MEMBER 1.0 0.0 X 0 0 0 Ray Thurston Board member (PT YR) 1.0 0.0 X 0 0 0 HOWARD YOUNG Board member 1.0 0.0 X 0 0 0 0 2681511 413911 0 false true false 0 3753754 383606 3753754 0 18699 18699 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3772453 18699 X 12765361 12765361 0 0 0 0 0 0 292270 0 29227 263043 0 0 0 0 737299 0 73730 663569 0 0 0 0 174864 0 17486 157378 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2159 0 216 1943 134029 0 13403 120626 22 0 2 20 0 0 0 0 101078 0 10108 90970 896 0 90 806 0 0 0 0 33486 0 3349 30137 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 DUES & SUBSCRIPTIONS 620 0 620 0 RECRUITMENT EXPENSES 34 0 34 0 ALL OTHER EXPENSES 85 0 85 0 14242203 12765361 148350 1328492 0 2208026 0 24932881 23891719 9783792 335227 1433 0 0 0 0 0 0 0 0 0 8423 8423 0 0 0 0 0 0 0 0 0 0 0 0 0 0 36934555 24235369 10636405 8428295 0 0 101346 73150 0 0 0 0 0 0 0 0 0 0 0 0 10737751 8501445 X -8418531 -8918290 34615335 24652214 26196804 15733924 36934555 24235369 -10469750 6870 0 0 0 X false true X true false X 8383173 5436735 9036988 22935783 3753754 49546433 0 0 8383173 5436735 9036988 22935783 3753754 49546433 20213667 29332766 1763 4120 65940 127078 18699 217600 0 0 49764033 0.58944 0.60010 X SCHEDULE A, PART II THE AMOUNTS INCLUDED IN SCHEDULE A, PART II CORRESPOND TO THE FOLLOWING PERIODS: COLUMN (E) 2020 : 10/01/2020-09/30/2021 COLUMN (D) 2019 : 10/01/2019-09/30/2020 COLUMN (C) 2018 : 10/01/2018-09/30/2019 COLUMN (B) 2017 : 10/01/2017-09/30/2018 COLUMN (A) 2016 : 01/01/2017-09/30/2017 (SHORT PERIOD) RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED 1962082 173542 14478 6117 2143985 1562158 378481 28796 7353 1962082 190389 1373720 11402 13353 1562158 108695 75833 13214 7353 190389 62093 46076 10642 4658 5458 108695 0.00000 0.02900 0.97100 false false 0 0 X SCHEDULE D, PART V, LINE 4 TGEN FOUNDATION CLASSIFIES AS PERMANENTLY RESTRICTED NET ASSETS (1) THE ORIGINAL VALUE OF THE GIFT DONATED TO THE PERMANENT ENDOWMENT, (2) THE ORIGINAL VALUE OF SUBSEQUENT GIFTS DONATED TO THE PERMANENT ENDOWMENT, AND (3) ACCUMULATIONS TO THE PERMANENT ENDOWMENT MADE IN ACCORDANCE WITH THE DIRECTION OF THE APPLICABLE DONOR GIFT INSTRUMENT. TGEN FOUNDATION HAS A TEMPORARILY RESTRICTED ASSET WHICH HAS BEEN DESIGNED TO SUPPORT A SUMMER INTERN EACH YEAR AT TGEN. TGEN FOUNDATION'S POLICY FOR APPROPRIATING THE DISTRIBUTION OF ITS SUMMER INTERNSHIP PROGRAM ENDOWMENT HAS BEEN DESIGNED TO SUPPORT A GRANT TO TGEN FOR AN INTERN EACH YEAR FOR 25 YEARS. THE FOUNDATION CONSIDERED THE LONG-TERM EXPECTED RETURN ON ITS ENDOWMENT. TGEN FOUNDATION HAS A RESTRICTED ASSET FOR THE ESTABLISHMENT OF AN ENDOWED CHAIR IN BRAIN CANCER RESEARCH. TGEN FOUNDATION ALSO HAS A RESTRICTED ASSET WHICH ALLOWS THEM TO USE ANY INVESTMENT INCOME FOR OPERATING EXPENSES. SCHEDULE D, PART X, LINE 2 THE FOLLOWING PARAGRAPH IS FROM THE CITY OF HOPE CONSOLIDATED AUDITED FINANCIAL STATEMENTS AS OF SEPTEMBER 30, 2021 (WHICH INCLUDES CITY OF HOPE, CITY OF HOPE NATIONAL MEDICAL CENTER, CITY OF HOPE MEDICAL FOUNDATION, BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE, THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE AND ITS AFFILIATES, SOUTHERN CALIFORNIA RADIATION ONCOLOGY, LLC, ACCESSHOPE, LLC, AND CITY OF HOPE AUXILIARIES (AUXILIARIES)): FINANCIAL ACCOUNTING STANDARDS BOARD (FASB) ACCOUNTING STANDARDS CODIFICATION TOPIC ASC 740, INCOME TAXES, CLARIFIES THE ACCOUNTING FOR INCOME TAXES BY PRESCRIBING A MINIMUM RECOGNITION THRESHOLD THAT A TAX POSITION IS REQUIRED TO MEET BEFORE BEING RECOGNIZED IN THE FINANCIAL STATEMENTS. ASC 740 ALSO PROVIDES GUIDANCE ON DE-RECOGNITION, MEASUREMENT, CLASSIFICATION, INTEREST AND PENALTIES, DISCLOSURE, AND TRANSITION. THE GUIDANCE CONTAINED IN ASC 740 IS APPLICABLE TO PASS-THROUGH ENTITIES AND TAX-EXEMPT ORGANIZATIONS. CITY OF HOPE HAS NO SIGNIFICANT UNCERTAIN TAX POSITIONS OR TAX LIABILITY FOR TAX BENEFITS INTEREST, OR PENALTIES ACCRUED AT SEPTEMBER 30, 2021 AND 2020. true TRANSLATIONAL GENOMICS RESEARCH INSTITUTE 445 N 5TH ST STE 600 PHOENIX AZ 85004 753065445 501(c)(3) 12765361 FUNDRAISING FOR TGEN 1 SCHEDULE I, PART I, LINE 2 THE FOUNDATION IS ORGANIZED EXCLUSIVELY TO BENEFIT TGEN, A RELATED 501(C)(3) TAX-EXEMPT ORGANIZATION, BY SUPPORTING TGEN'S FUNDRAISING AND DEVELOPMENT FUNCTIONS. THE FOUNDATION RELIES UPON THE GOVERNANCE PRACTICES OF TGEN TO MONITOR USE OF GRANT FUNDS. false true false false false false false true false JEFFREY M TRENT PHD BOARD MEMBER 0 847770 0 140000 0 59408 0 220536 0 28862 0 1296576 0 0 MANUEL ESTRADA CHIEF FINANCIAL OFFICER 0 302826 0 47411 0 1842 0 8571 0 12783 0 373433 0 0 ERIN MASSEY CHIEF DEVELOPMENT OFFICER 0 280599 0 126500 0 1540 0 11263 0 4518 0 424420 0 0 TERESA BURLESON BOARD MEMBER/ASST TREASURER 0 505283 0 366490 0 1842 0 115233 0 12145 0 1000993 0 0 SCHEDULE J, PART I, LINE 3 TGEN FOUNDATION DOES NOT DETERMINE OR PAY ANY COMPENSATION OR BENEFITS. ALL COMPENSATION AND BENEFITS ARE DETERMINED AND PAID BY TGEN, A RELATED TAX-EXEMPT ORGANIZATION. SCHEDULE J, PART I, LINE 7 SOME OF TGEN FOUNDATION'S OFFICERS LISTED IN FORM 990, PART VII, WERE PAID BONUSES WHICH WERE BASED ON ACCOMPLISHMENTS OF SPECIFIC MILESTONES AND/OR PERFORMANCE METRICS, AS APPROVED BY THE TGEN BOARD OF DIRECTORS. X 383606 FMV false true false FORM 990, PART III, LINE 4A Research progressed markedly in 2021, this included a number of research and clinical advances; peer-reviewed scientific papers; grants and contracts; education and outreach efforts; and, near- and long-term opportunities to advance and strengthen TGen's presence in biomedical research and clinical care. Translational Genomics Research Institute (TGEN) achieved success across multiple areas. Our virus genomic sequencing abilities increased by almost 10-fold over the previous two years (fueled by the Delta variant). This work enabled the development of a 21st Century public-health and infectious-disease monitoring system, enabled by better, faster, more accurate - and cost effective - sequencing tools. TGen, for example, was the first to confirm the presence in Arizona of the Delta variant, and we predicted as early as May that this extremely contagious form of the virus would dominate new cases in Arizona. By August, Delta represented 99 percent of the state's new cases. These capabilities resulted in multi-million-dollar contracts with the Arizona Department of Health Services and with the U.S. Center for Disease Control and Prevention for sequencing positive cases of the SARS-CoV-2 virus. Enhanced sequencing capabilities also underpin projects like MindCrowd, which now has more than 225,000 test subjects from across the globe driving a study for how healthy brains work at different ages. ADVANCED GENOMIC SEQUENCING WILL BE THE BACKBONE OF AN ANTI-CANCER DRUG DEVELOPMENT PROGRAM. Based on the genomic profile of each patient, this project will employ the retraining of immune system cells - taken out of the patient, multiplied in the lab, and then returned to the same patient - to fight the cancer. In addition, an anti-cancer vaccine is being developed that would further stimulate the immune system against the tumor. Theoretically, this approach could be applied to numerous types of cancer. TGEN'S PARTNERSHIPS HAVE RESULTED IN VARIOUS MULTI-YEAR, MULTI-MILLION DOLLAR EFFORTS FUNDED BY THE NATIONAL INSTITUTES OF HEALTH IN VARIOUS AREAS. ADDITIONALLY, TGEN INVESTIGATORS WERE AWARDED GRANTS IN MULTIPLE FIELDS, INCLUDING NEUROGENOMICS, CANCER THERAPEUTICS AND TREATMENTS, AND DISEASE DETECTION AND MONITORING. TGEN ADVANCED A SERIES OF INNOVATIVE RESEARCH INITIATIVES THAT YIELDED NUMEROUS SCIENTIFIC DISCOVERIES (MANY WITH POTENTIAL CLINICAL APPLICATION), ESTABLISHED NATIONAL AND INTERNATIONAL COLLABORATIONS, AND LED NEW AND EXCITING CLINICAL TRIALS WITH PROMISING RESULTS IN THE AREAS OF PATHOGENIC DISEASE, CANCER DIAGNOSIS AND MONITORING, NEUROGENOMICS, AND CANINE CANCER. SPECIFICALLY, TGEN INVESTIGATORS ARE SEQUENCING SAMPLES FROM COVID-19 PATIENTS TO ANALYZE THE VIRUS' GENETIC CODES AND TRACK ITS DIFFERENT STRAINS, ANALYZING DNA SHED INTO A PATIENT'S BLOODSTREAM TO PROVIDE A NONINVASIVE MEANS OF DETECTING THE PRESENCE OF A TUMOR, USING BLOOD SAMPLES AND A UNIQUE PROTEOMICS-BASED TECHNOLOGY TO DEVELOP A TEST TO IDENTIFY INFINITESIMALLY SMALL BREAST CANCER BIOMARKERS SHED INTO THE BLOODSTREAM, CREATING A COMPREHENSIVE RNA TRANSCRIPTOMIC RESOURCE FROM WHOLE BLOOD SAMPLES FOR USE BY THE PARKINSON'S RESEARCH COMMUNITY FOR BIOMARKER DEVELOPMENT ALLOWING SCIENTISTS TO INTERROGATE GENES, PATHWAYS AND MECHANISMS THAT PLAY A ROLE IN THE GENESIS AND PROGRESSION OF PARKINSON'S, ASSESSING THE RELATIONSHIP BETWEEN SMOKING, CARDIOVASCULAR DISEASE AND VERBAL MEMORY, AND IDENTIFYING A GENE THAT COULD NOT ONLY REDUCE THE DEPOSITION OF A HARD PLAQUES IN THE BARIN THAT LEADS TO ALZHEIMER'S DISEASE BUT ALSO MIGHT PREVENT OR DELAY THIS MEMORY-ROBBING DISEASE FROM DEVELOPING. TGEN INVESTIGATORS PUBLISHED THEIR RESEARCH RESULTS EXTENSIVELY IN SCHOLARLY PEER-REVIEWED ACADEMIC JOURNALS AND PRESENTED VIRTUALLY AT LEADING NATIONAL AND INTERNATIONAL CONFERENCES; INCLUDING PUBLICATION IN LEADING SCIENTIFIC JOURNALS SUCH AS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, CANCER RESEARCH, SCIENCE TRANSLATIONAL MEDICINE, NATURE AGING AND MECHANISMS OF DISEASE, NATURE COMMUNICATIONS, AND PRESENTATIONS AT LEADING CONFERENCES SUCH AS THE AACR VIRTUAL SPECIAL CONFERENCE ON PANCREATIC CANCER. TGEN INVESTIGATORS FURTHER SERVE AS RESOURCES TO MEDICAL AND SCIENTIFIC RESEARCH CENTERS THROUGHOUT THE COUNTRY IN THEIR AREAS OF RESEARCH. IN EDUCATION AND OUTREACH, TGEN PROVIDED INTERNSHIPS TO STUDENTS IN PROGRAMS THAT FOCUSED ON DEVELOPING PROFESSIONAL AND SCIENTIFIC SKILLS. ADDITIONALLY, TGEN PROVIDED A BIOSCIENCE LEADERSHIP ACADEMY FOR STUDENTS WHERE THEY LEARNED ABOUT A VARIETY OF TOPICS WITHIN THE THEMES OF STEM PROFESSIONAL SKILLS, NETWORKING, LEADERSHIP, TRANSLATIONAL MEDICINE, AND HOT TOPICS IN THE BIOSCIENCES. FORM 990, PART V, LINE 2A; PART VII, SECTION A; AND PART IX TGEN FOUNDATION DOES NOT HAVE EMPLOYEES, BUT SHARES THE COST OF PERSONNEL, SERVICES, FACILITIES AND EXPENSES WITH TGEN, A RELATED TAX-EXEMPT ORGANIZATION. FORM 990, PART VI, LINE 2 MICHEAL KAPLAN AND BENNETT DORRANCE HAVE A FAMILY RELATIONSHIP. FORM 990, PART VI, LINE 6 THE SOLE CORPORATE MEMBER OF TGEN FOUNDATION IS THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (TGEN). FORM 990, PART VI, LINE 7A TGEN, AS THE SOLE CORPORATE MEMBER OF TGEN FOUNDATION, HAS THE RIGHT TO ELECT THE BOARD OF DIRECTORS OF TGEN FOUNDATION. FORM 990, PART VI, LINE 7B THE SOLE CORPORATE MEMBER'S VOTE SHALL BE REQUIRED ON: (A) THE ELECTION AND REMOVAL OF ELECTED DIRECTORS AS SET FORTH IN THE BYLAWS; (B) THE ADOPTION OF ANY PLAN OF MERGER OR CONSOLIDATION; (C) THE SALE OF ALL OR SUBSTANTIALLY ALL THE FOUNDATION'S ASSETS IN A SINGLE TRANSACTION OR SERIES OF RELATED TRANSACTIONS; (D) THE AMENDMENT OF THE FOUNDATION'S ARTICLES OF INCORPORATION OR BYLAWS; (E) THE INSTITUTION, OR CONSENT TO INSTITUTION, OF PROCEEDINGS TO ADJUDICATE THE FOUNDATION BANKRUPT OR INSOLVENT, OR THE FILING OF A PETITION SEEKING OR CONSENTING TO REORGANIZATION OR RELIEF UNDER ANY LAW RELATING TO BANKRUPTCY, INSOLVENCY, OR OTHER RELIEF FOR DEBTORS, OR THE CONSENT TO THE APPOINTMENT OF A RECEIVER, LIQUIDATOR, ASSIGNEE, TRUSTEE, SEQUESTRATOR (OR SIMILAR OFFICIAL) OF THE FOUNDATION OR OF ALL OR ANY SUBSTANTIAL PART OF ITS PROPERTY, OR THE MAKING OF ANY ASSIGNMENT FOR THE BENEFIT OF CREDITORS, OR THE ADMISSION IN WRITING OF THE FOUNDATION'S INABILITY TO PAY ITS DEBTS GENERALLY AS THEY BECOME DUE, OR ANY STEPS IN FURTHERANCE OF SUCH ACTIONS; AND (F) THOSE MATTERS UPON WHICH THE MEMBER IS GRANTED VOTING RIGHTS IN THE ARTICLES OF INCORPORATION, BYLAWS, OR THE ARIZONA NONPROFIT CORPORATION ACT. THE SOLE CORPORATE MEMBER HAS THE FOLLOWING RESERVE POWERS: (A) APPOINT AND REMOVE THE PRESIDENT; (B) APPROVE THE ESTABLISHMENT OF NEW CORPORATE PARTNERSHIP ENTITIES CREATED OR JOINED BY THE FOUNDATION; (C) APPROVE THE FOUNDATION'S EXECUTION OF MATERIAL CONTRACTS; AND (D) APPROVE THE FOUNDATION'S INCURRENCE OF MATERIAL DEBTS. FORM 990, PART VI, LINE 11B THE FORM 990 IS PREPARED BY AN OUTSIDE ACCOUNTING FIRM BASED ON INFORMATION PROVIDED BY THE TGEN FINANCE DEPARTMENT. THE FORM 990 IS THEN REVIEWED BY THE FINANCE DEPARTMENT, OTHER MEMBERS OF MANAGEMENT AND THE AUDIT AND COMPLIANCE COMMITTEE OF THE CITY OF HOPE. THE FORM 990 IS POSTED ON THE BOARD WEBSITE FOR BOARD REVIEW PRIOR TO FILING WITH THE IRS. FORM 990, PART VI, LINE 12C TGEN DISTRIBUTES A CONFLICT OF INTEREST QUESTIONNAIRE ANNUALLY TO ALL DIRECTOR LEVEL POSITIONS AND ABOVE, IN ADDITION TO ANY OFFICERS AND KEY EMPLOYEES DESIGNATED BY THE CONFLICT OF INTEREST COMMITTEE. THE QUESTIONNAIRES ARE REVIEWED BY TGEN'S FINANCE DEPARTMENT AND THE OFFICE OF RESEARCH COMPLIANCE. THOSE EMPLOYEES WITH CONFLICTS ARE SENT FOR FURTHER REVIEW TO THE CONFLICT OF INTEREST COMMITTEE TO ENSURE AN APPROPRIATE PLAN IS SET FORTH. UPDATES TO THE LIST ARE HANDLED ON AN AS-NEEDED BASIS, BASED ON CONTRACT REVIEWS AND EMPLOYEE INFORMATION. FORM 990, PART VI, LINES 15A AND 15B THE EXECUTIVE COMPENSATION AND GOVERNANCE COMMITTEE OF THE MEMBER SHALL BE THE EXECUTIVE COMPENSATION COMMITTEE OF TGEN. THE COMPENSATION REVIEW PROCESS WAS LAST COMPLETED IN 2021. FORM 990, PART VI, LINE 19 TGEN FOUNDATION PROVIDES ITS GOVERNING DOCUMENTS AND CONFLICT OF INTEREST POLICY TO THE GENERAL PUBLIC UPON REQUEST. 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