<?xml version="1.0" encoding="utf-8"?>
<Return xmlns="http://www.irs.gov/efile" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" returnVersion="2021v4.0">
  <ReturnHeader binaryAttachmentCnt="0">
    <ReturnTs>2022-04-28T13:28:26-05:00</ReturnTs>
    <TaxPeriodEndDt>2021-12-31</TaxPeriodEndDt>
    <PreparerFirmGrp>
      <PreparerFirmEIN>270318607</PreparerFirmEIN>
      <PreparerFirmName>
        <BusinessNameLine1Txt>MCGEE COLLINS PC</BusinessNameLine1Txt>
      </PreparerFirmName>
      <PreparerUSAddress>
        <AddressLine1Txt>10629 FORD AVE</AddressLine1Txt>
        <CityNm>RICHMOND HILL</CityNm>
        <StateAbbreviationCd>GA</StateAbbreviationCd>
        <ZIPCd>31324</ZIPCd>
      </PreparerUSAddress>
    </PreparerFirmGrp>
    <ReturnTypeCd>990EZ</ReturnTypeCd>
    <TaxPeriodBeginDt>2021-01-01</TaxPeriodBeginDt>
    <Filer>
      <EIN>204875861</EIN>
      <BusinessName>
        <BusinessNameLine1Txt>LOWCOUNTRY DOWN SYNDROME SOCIETY</BusinessNameLine1Txt>
      </BusinessName>
      <BusinessNameControlTxt>LOWC</BusinessNameControlTxt>
      <PhoneNum>9127547800</PhoneNum>
      <USAddress>
        <AddressLine1Txt>1525 DEAN FOREST RD SUITE 500</AddressLine1Txt>
        <CityNm>SAVANNAH</CityNm>
        <StateAbbreviationCd>GA</StateAbbreviationCd>
        <ZIPCd>31408</ZIPCd>
      </USAddress>
    </Filer>
    <BusinessOfficerGrp>
      <PersonNm>STEPHEN GREENE</PersonNm>
      <PersonTitleTxt>TREASURER</PersonTitleTxt>
      <PhoneNum>9126608804</PhoneNum>
      <SignatureDt>2022-04-28</SignatureDt>
      <DiscussWithPaidPreparerInd>true</DiscussWithPaidPreparerInd>
    </BusinessOfficerGrp>
    <SigningOfficerGrp>
      <PersonFullName>
        <PersonFirstNm>STEPHEN</PersonFirstNm>
        <PersonLastNm>GREENE</PersonLastNm>
      </PersonFullName>
      <SSN>999009999</SSN>
    </SigningOfficerGrp>
    <PreparerPersonGrp>
      <PreparerPersonNm>ELIZABETH A COLLINS</PreparerPersonNm>
      <PTIN>P00965858</PTIN>
      <PhoneNum>9127563453</PhoneNum>
      <PreparationDt>2022-04-28</PreparationDt>
    </PreparerPersonGrp>
    <TaxYr>2021</TaxYr>
    <BuildTS>2022-09-23 18:48:47Z</BuildTS>
  </ReturnHeader>
  <ReturnData documentCnt="3">
    <IRS990EZ documentId="RetDoc1" referenceDocumentId="RetDoc2">
      <MethodOfAccountingCashInd>X</MethodOfAccountingCashInd>
      <ScheduleBNotRequiredInd>X</ScheduleBNotRequiredInd>
      <WebsiteAddressTxt>WWW.LDSSGA.ORG</WebsiteAddressTxt>
      <Organization501c3Ind referenceDocumentId="RetDoc3">X</Organization501c3Ind>
      <TypeOfOrganizationCorpInd>X</TypeOfOrganizationCorpInd>
      <GrossReceiptsAmt>52609</GrossReceiptsAmt>
      <InfoInScheduleOPartIInd>X</InfoInScheduleOPartIInd>
      <ContributionsGiftsGrantsEtcAmt>52499</ContributionsGiftsGrantsEtcAmt>
      <InvestmentIncomeAmt>110</InvestmentIncomeAmt>
      <TotalRevenueAmt>52609</TotalRevenueAmt>
      <OtherExpensesTotalAmt>35839</OtherExpensesTotalAmt>
      <TotalExpensesAmt>35839</TotalExpensesAmt>
      <ExcessOrDeficitForYearAmt>16770</ExcessOrDeficitForYearAmt>
      <NetAssetsOrFundBalancesBOYAmt>161286</NetAssetsOrFundBalancesBOYAmt>
      <NetAssetsOrFundBalancesEOYAmt>178056</NetAssetsOrFundBalancesEOYAmt>
      <CashSavingsAndInvestmentsGrp>
        <BOYAmt>161286</BOYAmt>
        <EOYAmt>178056</EOYAmt>
      </CashSavingsAndInvestmentsGrp>
      <Form990TotalAssetsGrp>
        <BOYAmt>161286</BOYAmt>
        <EOYAmt>178056</EOYAmt>
      </Form990TotalAssetsGrp>
      <NetAssetsOrFundBalancesGrp>
        <BOYAmt>161286</BOYAmt>
        <EOYAmt>178056</EOYAmt>
      </NetAssetsOrFundBalancesGrp>
      <InfoInScheduleOPartIIIInd>X</InfoInScheduleOPartIIIInd>
      <PrimaryExemptPurposeTxt>PROMOTE AWARENESS OF DOWN SYNDROME</PrimaryExemptPurposeTxt>
      <ProgramSrvcAccomplishmentGrp>
        <DescriptionProgramSrvcAccomTxt>BUDDY WALK - DAY OF FESTIVITIES TO PROMOTE AWARENESS AND INCLUSION FOR INDIVIDUALS WITH DOWN SYNDROME. THE WALK WAS HELD VIRTUALLY AGAIN THIS YEAR DUE TO COVID 19 RESTRICTIONS.</DescriptionProgramSrvcAccomTxt>
        <ProgramServiceExpensesAmt>3760</ProgramServiceExpensesAmt>
      </ProgramSrvcAccomplishmentGrp>
      <ProgramSrvcAccomplishmentGrp>
        <DescriptionProgramSrvcAccomTxt>CALENDARS - ANNUAL CALENDARS FEATURING THE MEMBERS OF THE GROUP WITH DOWN SYNDROME TO BE USED AS AN ADVERTISING TOOL TO GENERATE MORE AWARENESS OF THE CONDITION AND THE PREVALENCE IN OUR COMMUNITY.</DescriptionProgramSrvcAccomTxt>
        <ProgramServiceExpensesAmt>6007</ProgramServiceExpensesAmt>
      </ProgramSrvcAccomplishmentGrp>
      <ProgramSrvcAccomplishmentGrp>
        <DescriptionProgramSrvcAccomTxt>CAMP BUDDY - 2 SUMMER CAMPS PROVIDING SPEECH, PHYSICAL, AND OCCUPATIONAL THERAPIES UNDER THE GUIDANCE OF CERTIFIED THERAPISTS AND SPECIAL EDUCATION PROFESSIONALS TO BRIDGE THE GAP FOR THOSE MISSING THE NEEDED THERAPIES DURING THE SUMMER MONTHS NOT IN SCHOOL.</DescriptionProgramSrvcAccomTxt>
        <ProgramServiceExpensesAmt>13069</ProgramServiceExpensesAmt>
      </ProgramSrvcAccomplishmentGrp>
      <ProgramSrvcAccomplishmentGrp>
        <DescriptionProgramSrvcAccomTxt>MONTHLY MEMBERSHIP MEETINGS HELD VIRTUALLY FOR MUCH OF 2021 AND MEMBER OUTINGS FOR MEMBER SUPPORT,INTERACTION, AND EDUCATION. DUE TO COVID-19 RESTRICTIONS MUCH OF THE NORMAL ACTIVITIES FOR 2021 WERE CURTAILED.</DescriptionProgramSrvcAccomTxt>
        <ProgramServiceExpensesAmt>12215</ProgramServiceExpensesAmt>
      </ProgramSrvcAccomplishmentGrp>
      <TotalProgramServiceExpensesAmt>35051</TotalProgramServiceExpensesAmt>
      <OfficerDirectorTrusteeEmplGrp>
        <PersonNm>JOE MARCHESE</PersonNm>
        <TitleTxt>PRESIDENT</TitleTxt>
        <AverageHrsPerWkDevotedToPosRt>000.00</AverageHrsPerWkDevotedToPosRt>
        <CompensationAmt>0</CompensationAmt>
      </OfficerDirectorTrusteeEmplGrp>
      <OfficerDirectorTrusteeEmplGrp>
        <PersonNm>MICHAEL HOLTON</PersonNm>
        <TitleTxt>VICE PRESIDE</TitleTxt>
        <AverageHrsPerWkDevotedToPosRt>000.00</AverageHrsPerWkDevotedToPosRt>
        <CompensationAmt>0</CompensationAmt>
      </OfficerDirectorTrusteeEmplGrp>
      <OfficerDirectorTrusteeEmplGrp>
        <PersonNm>JULIE HARDEMAN</PersonNm>
        <TitleTxt>SECRETARY</TitleTxt>
        <AverageHrsPerWkDevotedToPosRt>000.00</AverageHrsPerWkDevotedToPosRt>
        <CompensationAmt>0</CompensationAmt>
      </OfficerDirectorTrusteeEmplGrp>
      <OfficerDirectorTrusteeEmplGrp>
        <PersonNm>STEPHEN GREENE</PersonNm>
        <TitleTxt>TREASURER</TitleTxt>
        <AverageHrsPerWkDevotedToPosRt>000.00</AverageHrsPerWkDevotedToPosRt>
        <CompensationAmt>0</CompensationAmt>
      </OfficerDirectorTrusteeEmplGrp>
      <ActivitiesNotPreviouslyRptInd>false</ActivitiesNotPreviouslyRptInd>
      <ChgMadeToOrgnzngDocNotRptInd>false</ChgMadeToOrgnzngDocNotRptInd>
      <OrganizationHadUBIInd>false</OrganizationHadUBIInd>
      <SubjectToProxyTaxInd>false</SubjectToProxyTaxInd>
      <OrganizationDissolvedEtcInd>false</OrganizationDissolvedEtcInd>
      <Form1120PolFiledInd>false</Form1120PolFiledInd>
      <MadeLoansToFromOfficersInd>false</MadeLoansToFromOfficersInd>
      <EngagedInExcessBenefitTransInd>false</EngagedInExcessBenefitTransInd>
      <ProhibitedTaxShelterTransInd>false</ProhibitedTaxShelterTransInd>
      <BooksInCareOfDetail>
        <BusinessName>
          <BusinessNameLine1Txt>MCGEE COLLINS PC</BusinessNameLine1Txt>
        </BusinessName>
        <USAddress>
          <AddressLine1Txt>10629 FORD AVENUE</AddressLine1Txt>
          <CityNm>RICHMOND HILL</CityNm>
          <StateAbbreviationCd>GA</StateAbbreviationCd>
          <ZIPCd>31324</ZIPCd>
        </USAddress>
        <PhoneNum>9127563453</PhoneNum>
      </BooksInCareOfDetail>
      <ForeignFinancialAccountInd>false</ForeignFinancialAccountInd>
      <ForeignOfficeInd>false</ForeignOfficeInd>
      <DonorAdvisedFndsInd>false</DonorAdvisedFndsInd>
      <OperateHospitalInd>false</OperateHospitalInd>
      <TanningServicesProvidedInd>false</TanningServicesProvidedInd>
      <RelatedOrganizationCtrlEntInd>false</RelatedOrganizationCtrlEntInd>
      <TransactionWithControlEntInd>false</TransactionWithControlEntInd>
      <PoliticalCampaignActyInd>false</PoliticalCampaignActyInd>
      <LobbyingActivitiesInd>false</LobbyingActivitiesInd>
      <SchoolOperatingInd>false</SchoolOperatingInd>
      <TrnsfrExmptNonChrtblRltdOrgInd>false</TrnsfrExmptNonChrtblRltdOrgInd>
      <PartVIOfCompOfHghstPdEmplTxt>NONE</PartVIOfCompOfHghstPdEmplTxt>
      <PartVIHghstPdCntrctProfSrvcTxt>NONE</PartVIHghstPdCntrctProfSrvcTxt>
      <FiledScheduleAInd>true</FiledScheduleAInd>
    </IRS990EZ>
    <IRS990ScheduleA documentId="RetDoc3">
      <PubliclySupportedOrg509a2Ind>X</PubliclySupportedOrg509a2Ind>
      <GiftsGrantsContrisRcvd509Grp>
        <CurrentTaxYearMinus4YearsAmt>95239</CurrentTaxYearMinus4YearsAmt>
        <CurrentTaxYearMinus3YearsAmt>167128</CurrentTaxYearMinus3YearsAmt>
        <CurrentTaxYearMinus2YearsAmt>151395</CurrentTaxYearMinus2YearsAmt>
        <CurrentTaxYearMinus1YearAmt>78341</CurrentTaxYearMinus1YearAmt>
        <CurrentTaxYearAmt>52499</CurrentTaxYearAmt>
        <TotalAmt>544602</TotalAmt>
      </GiftsGrantsContrisRcvd509Grp>
      <Total509Grp>
        <CurrentTaxYearMinus4YearsAmt>95239</CurrentTaxYearMinus4YearsAmt>
        <CurrentTaxYearMinus3YearsAmt>167128</CurrentTaxYearMinus3YearsAmt>
        <CurrentTaxYearMinus2YearsAmt>151395</CurrentTaxYearMinus2YearsAmt>
        <CurrentTaxYearMinus1YearAmt>78341</CurrentTaxYearMinus1YearAmt>
        <CurrentTaxYearAmt>52499</CurrentTaxYearAmt>
        <TotalAmt>544602</TotalAmt>
      </Total509Grp>
      <PublicSupportTotal509Amt>544602</PublicSupportTotal509Amt>
      <GrossInvestmentIncome509Grp>
        <CurrentTaxYearMinus4YearsAmt>344</CurrentTaxYearMinus4YearsAmt>
        <CurrentTaxYearMinus3YearsAmt>714</CurrentTaxYearMinus3YearsAmt>
        <CurrentTaxYearMinus2YearsAmt>842</CurrentTaxYearMinus2YearsAmt>
        <CurrentTaxYearMinus1YearAmt>577</CurrentTaxYearMinus1YearAmt>
        <CurrentTaxYearAmt>110</CurrentTaxYearAmt>
        <TotalAmt>2587</TotalAmt>
      </GrossInvestmentIncome509Grp>
      <InvestmentIncomeAndUBTIGrp>
        <CurrentTaxYearMinus4YearsAmt>344</CurrentTaxYearMinus4YearsAmt>
        <CurrentTaxYearMinus3YearsAmt>714</CurrentTaxYearMinus3YearsAmt>
        <CurrentTaxYearMinus2YearsAmt>842</CurrentTaxYearMinus2YearsAmt>
        <CurrentTaxYearMinus1YearAmt>577</CurrentTaxYearMinus1YearAmt>
        <CurrentTaxYearAmt>110</CurrentTaxYearAmt>
        <TotalAmt>2587</TotalAmt>
      </InvestmentIncomeAndUBTIGrp>
      <TotalSupportCalendarYearGrp>
        <CurrentTaxYearMinus4YearsAmt>95583</CurrentTaxYearMinus4YearsAmt>
        <CurrentTaxYearMinus3YearsAmt>167842</CurrentTaxYearMinus3YearsAmt>
        <CurrentTaxYearMinus2YearsAmt>152237</CurrentTaxYearMinus2YearsAmt>
        <CurrentTaxYearMinus1YearAmt>78918</CurrentTaxYearMinus1YearAmt>
        <CurrentTaxYearAmt>52609</CurrentTaxYearAmt>
        <TotalAmt>547189</TotalAmt>
      </TotalSupportCalendarYearGrp>
      <PublicSupportCY509Pct>0.99530</PublicSupportCY509Pct>
      <PublicSupportPY509Pct>0.99520</PublicSupportPY509Pct>
      <InvestmentIncomeCYPct>0.00000</InvestmentIncomeCYPct>
      <InvestmentIncomePYPct>0.00000</InvestmentIncomePYPct>
      <ThirtyThrPctSuprtTestsCY509Ind>X</ThirtyThrPctSuprtTestsCY509Ind>
    </IRS990ScheduleA>
    <IRS990ScheduleO documentId="RetDoc2">
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990-EZ, PART I, LINE 16</FormAndLineReferenceDesc>
        <ExplanationTxt>EXPENSES OFFICER AND COMMITTEES 209 ADVERTISING 8,471 TELEPHONE 309 OFFICE SUPPLIES 75 LICENSES 30 SUPPLIES 784 DUES AND SUBCRIPTIONS 594 INSURANCE 1,820 BUDDY WALK 3,760 CAMP BUDDY 13,069 BANK CHARGES 165 CALENDARS 6,007 CONTRIBUTIONS 546 TOTAL 35,839</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990-EZ, PART III, LINE 30</FormAndLineReferenceDesc>
        <ExplanationTxt>CAMP BUDDY - 2 SUMMER CAMPS PROVIDING SPEECH, PHYSICAL, AND OCCUPATIONAL THERAPIES UNDER THE GUIDANCE OF CERTIFIED THERAPISTS AND SPECIAL EDUCATION PROFESSIONALS TO BRIDGE THE GAP FOR THOSE MISSING THE NEEDED THERAPIES DURING THE SUMMER MONTHS NOT IN SCHOOL.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990-EZ, PART III, LINE 31</FormAndLineReferenceDesc>
        <ExplanationTxt>MONTHLY MEMBERSHIP MEETINGS HELD VIRTUALLY FOR MUCH OF 2021 AND MEMBER OUTINGS FOR MEMBER SUPPORT,INTERACTION, AND EDUCATION. DUE TO COVID-19 RESTRICTIONS MUCH OF THE NORMAL ACTIVITIES FOR 2021 WERE CURTAILED.</ExplanationTxt>
      </SupplementalInformationDetail>
    </IRS990ScheduleO>
  </ReturnData>
</Return>
