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      <Desc>Research Development and Support: It is estimated that up to 10 billion homeless dogs and cats will be born in the next 10 years worldwide and that this overpopulation problem cannot be solved by sterilization surgeries nor by adoptions -- and to solve this problem, we are happy to report that this year, thanks to an increase in support, we succeeded in launching our largest clinical trials ever -- scientific studies designed to develop what will be the world's first one-dose permanent birth control formula (the Spay and Neuter Cookie) capable of ending this overpopulation problem -- which is also the number one cause, of suffering and death for dogs and for cats worldwide. We also succeeded in increasing the important high 'impaired follicle' count (over last year) -- produced by a single dose of our oral birth control CONTINUED... formulations (in other words, from a single Cookie) for female dogs (whom we first rescued and then of course adopted into caring homes). The higher the impaired follicle count the better, and the closer the animal (dog, cat and/or human) is, to being infertile. In 2022 we also succeeded in expanding our team of veterinary advisors and a variety of clinical scientists, to help increase the effectiveness of our permanent-lasting birth control formulas. Increasing the impaired follicle count and making these results consistent, are crucial to ending this global overpopulation problem. We were also able to confirm that, based on studies by others, one of our primary active ingredients (vinylcyclohexene dioxide) does not cause cancer in various animal species when administered daily over a significant period of time -- which is good news. Unfortunately due to a continued lack of funds, this year we reluctantly made the decision to, for the time being, not attempt to transfer our studies into the U.S. Instead, we increased our concentration on carrying out and expanding our animal birth control clinical trials outside the U.S. We nonetheless also continued to save funds as much as possible, to be able to afford near-future U.S.-based birth control studies which would produce data acceptable for submission to the FDA for regulatory approval for use of the Cookie in the U.S. (and speed up the development process) -- all of which requires financing which continues to be beyond our reach.</Desc>
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