2024-10-14T08:11:40-05:00 2021-12-31 812950760 SAX LLP 1040 AVENUE OF THE AMERICAS-16TH FL NEW YORK NY 10018 990 2021-01-01 237376197 HEREDITARY DISEASE FOUNDATION HERE 2129812121 601 WEST 168TH STREET 54 NEW YORK NY 10032 MEGHAN DONALDSON CEO 2129812121 2024-10-14 1 MIKE SCHALL P02024184 2122682804 2024-10-11 2021 2024-10-15 13:58:12Z MEGHAN DONALDSON 601 WEST 168TH STREET 54 NEW YORK NY 10032 5869907 0 X WWW.HDFOUNDATION.ORG X 1968 CA FUND INNOVATIVE RESEARCH TOWARDS CURING HUNTINGTON'S DISEASE AND IMPACTING OTHER BRAIN DISORDERS. 16 15 3 17 0 0 3654196 2827274 0 0 387663 1019375 17960 0 4059819 3846649 1782780 2114614 0 0 364606 358003 68000 103500 297303 304275 391507 2519661 2967624 1540158 879025 15507063 18145612 1781608 2330017 13725455 15815595 X TO FUND INNOVATIVE RESEARCH TOWARDS CURING HUNTINGTON'S DISEASE AND IMPACTING OTHER BRAIN DISORDERS. 0 0 2403646 2114614 THE HEREDITARY DISEASE FOUNDATION COMMEMORATES ITS 52ND YEAR BY MAKING AN EVEN GREATER IMPACT TOWARD DEVELOPING NOVEL THERAPEUTICS AND CURES. WE HAVE PUT IN PLACE STRATEGIES AND NEW GRANT FUNDING PROGRAMS TO MAXIMIZE OUR EFFECTIVENESS. WE HAVE BEEN FUNDING CATALYTIC AND PARADIGM-CHANGING RESEARCH SINCE OUR BIRTH - INCLUDING IDENTIFYING THE HUNTINGTON'S DISEASE MARKER IN 1983 AND THE HD GENE IN 1993, AND SUPPORTING GENE SILENCING APPROACHES SINCE 2002. WE WANT TO CONTINUE TO MAKE AN IMPACT BY FUNDING RESEARCH THAT PUSHES THE ENVELOPE.THE HEREDITARY DISEASE FOUNDATION PROVIDES FUNDING FOR RESEARCH THAT ADVANCES THE DISCOVERY AND DEVELOPMENT OF TREATMENTS FOR HUNTINGTON'S DISEASE AND OTHER BRAIN DISORDERS. WE ARE PASSIONATE ABOUT FUNDING AND THE FOUNDATION INTENDS TO USE THE ENDOWMENT FUNDS FOR ITS SCIENTIFIC ACTIVITIES WHICH INCLUDES PROVIDING GRANTS TO FUND SCIENTIFIC RESEARCH TO FURTHER THE UNDERSTANDING OF, AND TO DEVELOP DIAGNOSTICS AND THERAPEUTICS FOR NEURODEGENERATIVE DISEASES, INCLUDING HUNTINGTON'S DISEASE. THE HEREDITARY DISEASE FOUNDATION FUNDS THE MOST INNOVATIVE, CREATIVE AND PARADIGM-CHANGING RESEARCH POSSIBLE. THE DATA GENERATED WITH HDF FUNDING OFTEN ALLOWS RESEARCHERS TO GET INITIAL FINDINGS THAT HELP THEM APPLY SUCCESSFULLY FOR LARGER, LONG-TERM FUNDING FROM OTHER FUNDING AGENCIES, INCLUDING THE NATIONAL INSTITUTES OF HEALTH. THE FOUNDATION'S CURRENT FOCUS IS ON:1) MODIFIER STUDIES - ON DNA REPAIR PATHWAYS, PROTEIN DEGRADATION AND OTHER MODIFIERS OF PHENOTYPE AND AGE OF ONSET.2) RESEARCH MECHANISMS OF HD NEUROGENERATION AND BIOMARKERS AND THERAPY FOR HD-INDUCED NEURODEGENERATION.TYPE OF FUNDING:THE BASIC RESEARCH GRANTS PROGRAM: SUPPORTS PROJECTS CONTRIBUTING TO IDENTIFYING AND UNDERSTANDING THE FUNDAMENTAL DEFECTS IN HUNTINGTON'S DISEASE. POSTDOCTORAL FELLOWSHIPS: THESE POSTDOCTORAL FELLOWSHIPS ARE INTENDED TO CULTIVATE INTEREST IN HUNTINGTON'S DISEASE RESEARCH BY BRIGHT YOUNG SCIENTISTS. FELLOWSHIPS ARE GRANTED TO THOSE WHO POSSESS IMAGINATION, RIGOR, CREATIVITY AND SPIRIT TO PUSH FORWARD TOWARD A CURE FOR HD AND ENSURE THAT THESE LEARNING CAN BE APPLIED TO OTHER BRAIN DISEASES. 2403646 1 1 0 0 0 0 0 0 0 1 1 0 0 0 0 1 1 0 0 0 1 1 0 1 1 0 0 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 3 1 0 0 0 0 0 1 1 0 0 0 0 0 0 X 16 15 1 0 0 0 0 0 0 1 1 0 0 1 1 1 1 1 0 1 0 0 CA NY X X KENNETH MARTIN 2129282121 601 WEST 168TH STREET NEW YORK NY 10033 NANCY S WEXLER PHD PRESIDENT 7.00 X X 0 0 0 DAVID ZWALLY CHAIR 1.00 X X 0 0 0 ANNE B YOUNG MD PHD VICE CHAIR 1.00 X X 0 0 0 BRUCE DONALDSON TREASURER 1.00 X X 0 0 0 ALICE WEXLER PHD SECRETARY 1.00 X X 0 0 0 ROBI BLUMENSTEIN DIRECTOR 1.00 X 0 0 0 BARRY EVENCHICK DIRECTOR 1.00 X 0 0 0 SANDY FOX DIRECTOR 1.00 X 0 0 0 BERTA A GEHRY DIRECTOR 1.00 X 0 0 0 FRANK O GEHRY DIRECTOR 1.00 X 0 0 0 KELLY POSNER GERSTENHABER PHD DIRECTOR 1.00 X 0 0 0 DAVID HOUSMAN PHD DIRECTOR 1.00 X 0 0 0 JOAN LEIMAN PHD DIRECTOR 1.00 X 0 0 0 KAREN NEWMAN DIRECTOR 1.00 X 0 0 0 HERBERT PARDES MD DIRECTOR 1.00 X 0 0 0 MEGHAN DONALDSON CEO 40.00 X X 110000 0 0 TRAVIS CAREY CFO 3.00 X 7700 0 0 117700 0 0 1 0 0 0 SUSAN QUINLAN MARTIN INC 10 MITCHELL PLACE STE 3 H NEW YORK NY 10017 EVENT PLANNER GALA 2021 103500 1 314001 2513273 2827274 245544 245544 2797089 2023258 773831 773831 773831 0 314001 0 0 3846649 0 0 1019375 1536230 1536230 578384 578384 117700 55000 40700 22000 165554 113728 17175 34651 53445 27589 16562 9294 21304 12782 4261 4261 35890 35890 103500 103500 85083 85083 121396 8780 40542 72074 1302 346 956 17701 10827 3475 3399 65000 38720 13280 13000 3268 1539 1015 714 19605 11678 4006 3921 7023 4183 1435 1405 PRINTING 31961 2325 552 29084 OTHERS 3278 1535 1743 2967624 2403646 266675 297303 272171 1008422 2379491 293222 416443 962814 4463 4663 98022 72810 44817 25212 12384273 15845874 5405 5405 15507063 18145612 13170 41675 1768438 2288342 1781608 2330017 X 3139960 3170541 10585495 12645054 13725455 15815595 15507063 18145612 879025 1211115 0 X 0 1 X 1 0 X 747377 2169236 1650090 3654196 2827274 11048173 747377 2169236 1650090 3654196 2827274 11048173 2994140 8054033 265653 317651 295551 262035 245544 1386434 25439 47508 17960 139069 229976 12664583 0.63590 0.56380 X RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED 10244052 1932598 512203 71125 11593322 9703171 1026040 485159 10244052 8534335 1595553 426717 9703171 8401672 676151 -543488 8534335 7700419 1155712 454459 8401672 1.00000 0 0 98022 72810 25212 25212 X 4972681 1211115 1211115 3761566 85083 85083 3846649 2882541 0 2882541 85083 85083 2967624 PART X, LINE 2: HDF DOES NOT BELIEVE ITS FINANCIAL STATEMENTS INCLUDE ANY MATERIAL, UNCERTAIN TAX POSITIONS. TAX FILINGS FOR THE PERIODS ENDING DECEMBER 31, 2018 AND LATER ARE SUBJECT TO EXAMINATION BY APPLICABLE TAXING AUTHORITIES. 1 AUSTRALIA GRANTS TO RECIPIENTS SCIENTIFIC RESEARCH 135320 FRANCE GRANTS TO RECIPIENTS SCIENTIFIC RESEARCH 73676 CANADA GRANTS TO RECIPIENTS SCIENTIFIC RESEARCH 269388 ITALY GRANTS TO RECIPIENTS SCIENTIFIC RESEARCH 100000 0 0 0 0 0 0 578384 0 578384 AUSTRALIA SCIENTIFIC RESEARCH 135320 WIRE TRANS. 0 FRANCE SCIENTIFIC RESEARCH 73676 WIRE TRANS. 0 CANADA SCIENTIFIC RESEARCH 269388 WIRE TRANS. 0 ITALY SCIENTIFIC RESEARCH 100000 WIRE TRANS. 0 4 0 0 0 0 0 0 PART I, LINE 2: HDF MONITORS ITS GRANTS BY REQUIRING SCIENCE RESEARCH PROGRESS REPORTS FROM GRANTEES AS A CONDITION TO FURTHER PAYMENTS OF ANY GRANT PAYABLE IN INSTALLMENTS, AND A FINAL REPORT ON COMPLETION OF THE RESEARCH. PART III ACCOUNTING METHOD: 0 SQM INC 10 MITCHELL PL STE 3H NY NY 10017 EVENT PLANNER 2021 GALA 0 314001 103500 210501 314001 103500 210501 FR EVENTS 314001 314001 314001 314001 1 BRIGHAM AND WOMENS HOSPITAL 399 REVOLUTION DRIVE SUITE 730 SOMERVILLE MA 02145 042312909 501 C (3) 75000 0 SCIENTIFIC RESEARCH CHILDREN'S HOSPITAL OF PHILADELPHIA 3401 CIVIC CENTER BLVD PHILADELPHIA PA 19146 231352166 502 C (3) 214388 0 SCIENTIFIC RESEARCH MASSACHUSETTS GENERAL HOSPITAL 55 FRUIT STREET BOSTON MA 02145 042697983 503 C (3) 203684 0 SCIENTIFIC RESEARCH MASSACHUSETTS INSTITUTE OF TECHNOLOGY 77 MASSACHUSETTS AVENUE CAMBRIDGE MA 021394307 042103594 504 C (3) 223328 0 SCIENTIFIC RESEARCH STANFORD UNIVERSITY 450 SERRA MALL STANFORD PALO ALTO CA 94305 941156365 505 C (3) 205656 0 SCIENTIFIC RESEARCH THOMAS JEFFERSON UNIVERSITY 833 CHESTNUT STREET PHILADELPHIA PA 19107 231352651 506 C (3) 135320 0 SCIENTIFIC RESEARCH TRUSTEES OF COLUMBIA UNIVERSITY 615 WET 131ST STREET 4TH FLOOR NEW YORK NY 10027 135598093 507 C (3) 50000 0 SCIENTIFIC RESEARCH UNIVERSITY OF ALABAMA AT BIRMINGHAM 1720 2ND AVENUE SOUTH AB 1170 BIRMINGHAM AL 352940111 636005396 508 C (3) 75000 0 SCIENTIFIC RESEARCH UNIVERSITY OF CALIFORNIA IRVINE 160 ALDRICH HALL IRVINE CA 926977600 952226406 509 C (3) 200584 0 SCIENTIFIC RESEARCH UNIVERSITY OF TEXAS 301 UNIVERSITY BOULEVARD 3508 REBECCA SEALY HOSPITAL GALVESTON TX 775550156 746000949 510 C (3) 75000 0 SCIENTIFIC RESEARCH WASHINGTON UNIVERSITY 660 S EUCLID AVENUE CAMPUS BOX 8233 SAINT LOUIS MO 63110 430653611 511 C (3) 78270 0 SCIENTIFIC RESEARCH 11 PART I, LINE 2: HDF MONITORS ITS GRANTS BY REQUIRING SCIENCE RESEARCH PROGRESS REPORTS FROM GRANTEES AS A CONDITION TO FURTHER PAYMENTS OF ANY GRANT PAYABLE IN INSTALLMENTS, AND A FINAL REPORT ON COMPLETION OF THE RESEARCH. DAVID HOUSEMAN BOARD MEMBER 75000 RESEARCH GRANT FORM 990, PART VI, SECTION A, LINE 2 NANCY WEXLER, PRESIDENT, AND ALICE WEXLER, SECRETARY, ARE SISTERS AND BOTH ARE MEMBERS OF THE BOARD OF DIRECTORS. MEGHAN DONALDSON, CEO, AND BRUCE DONALDSON, BOARD MEMBER, ARE MARRIED AND ARE BOTH MEMBERS OF THE BOARD OF DIRECTORS. FRANK GEHRY AND BERTA GEHRY ARE MARRIED AND BOTH ARE MEMBERS OF THE BOARD OF DIRECTORS. SANDY FOX IS THE AUNT OF DAVID ZWALLY AND BOTH ARE MEMBERS OF THE BOARD OF DIRECTORS. FORM 990, PART VI, SECTION B, LINE 11B THE FOUNDATION PROVIDES THE 990 TO THE BOARD OF DIRECTORS FOR APPROVAL. FORM 990, PART VI, SECTION B, LINE 12C ANNUAL CONFLICT OF INTEREST STATEMENTS ARE CIRCULATED TO ALL OFFICERS, DIRECTORS, AND KEY EMPLOYEES AT THE BOARD OF DIRECTORS MEETING. MANAGEMENT MAINTAINS SIGNED COPIES OF THESE STATEMENTS FOR ALL SUCH INDIVIDUALS TO ENSURE COMPLIANCE WITH THIS POLICY. FORM 990, PART VI, SECTION B, LINE 15A A WRITTEN EMPLOYEE CONTRACT IS ESTABLISHED AND APPROVED BY THE BOARD OR COMPENSATION COMMITTEE. FORM 990, PART VI, SECTION C, LINE 19 THE FOUNDATION MAKES ITS FINANCIAL STATEMENTS AND 990 AVAILABLE TO THE PUBLIC ON ITS WEBSITE, WWW.HDFOUNDATION.ORG. THE FOUNDATION MAKES ITS GOVERING DOCUMENTS AND CONFLICTS OF INTEREST POLICY AVAILABLE TO THE PUBLIC UPON REQUEST.