2024-05-23T13:21:34-05:00 2023-09-30 814234542 BPM LLP 2001 North Main Street Suite 360 Walnut Creek CA 945967253 990 2022-10-01 770207331 Palo Alto Veterans Institute for Research PALO 6502392800 3801 Miranda Avenue Palo Alto CA 94304 Elaine Staats CEO 6502392802 2024-05-22 1 Elaine Staats 999009999 0 Elena P Serebriakova P01382840 9252961040 2024-05-22 3 AAL1 IAL1 2022 2023-04-26 12:10:37Z PAVIR Elaine Staats 3801 Miranda Avenue Palo Alto CA 94304 30503398 0 X www.pavir.org X 1988 CA Advancing veteran and public health through innovative research. 13 2 248 0 0 0 19234972 21413596 10623749 8615163 33233 450437 30818 24202 29922772 30503398 0 0 0 0 15439467 17658723 0 0 0 14324664 13077942 29764131 30736665 158641 -233267 15643008 20719365 7469988 12724388 8173020 7994977 X See Schedule OPAVIR's mission is advancing Veterans and public health through innovative research. PAVIR works with more than 100 Principal Investigators and 200 research staff to support basic science, clinical and health services research to realize its mission. PAVIR's diverse studies span the entire spectrum of health research from the investigation of diseases in the laboratory through testing new drug treatments and developing improved models of health care delivery to looking at outcomes both individually and on a large scale. PAVIR's research addresses health challenges that have been faced especially by Veterans, including post-traumatic stress disorder, traumatic brain injury, geriatric medicine, rehabilitation, sleep and other Veterans and public health issues. PAVIR's investigators have appointments at the VA Palo Alto Health Care System and most also hold appointments at the Stanford University School of Medicine. 0 0 2484611 All of Us Research Program. Principal investigators: Philip Tsao, Ph.D. and Jennifer Lee, M.D., Ph.D.The All of Us Research Program (All of Us) is a large collaborative initiative sponsored by the National Institutes of Health (NIH). All of Us includes a consortium of awardees from multiple institutions, including the Department of Veterans Affairs. All of Us is working to improve healthcare through research by building a diverse database of participant self-report information, biospecimens, and Electronic Health Records that can inform future research on a variety of health conditions. VA participation in All of Us is overseen by three Co-PIs, located at the VA Palo Alto Healthcare System and the VA Boston Healthcare System. These two institutions serve as the Coordinating Centers for all participating VA sites, providing leadership and oversight. There are currently 19 VA active recruitment sites for the program. All centralized recruitment, engagement campaigns, and compliance with program requirements is managed by the VA PIs and their respective Coordinating Center teams. 891023 Intestinal Lymphocyte Trafficking. Principal investigator: Eugene Butcher, M.D.The Intestinal Lymphocyte Trafficking program is a multi-year research study that started in 2007. The objectives of this program are 1) to define the molecular and genetic mechanisms that control immune cell migration to the small and large intestines, 2) to elucidate how these genes and mechanisms control infection or contribute to disease, 3) to uncover improved approaches to monitor or induce mucosal immune responses (i.e. for vaccination against infectious diseases), and 4) new therapeutic possibilities that could lead to treatments for inflammatory bowel and allergic diseases of the GI tract. During the current period, there was a discovery of a novel lung and upper GI tract trafficking program (novel chemoattractant receptor ligand pair). This discovery promises to have broad importance for upper GI (stomach), airway, and lung immunobiology. The study has yielded 25 peer reviewed manuscripts, 2 of which were in the last year. Additionally, presentations at both national and international meetings were made to share the progress of this study. 703221 Exploring Epigenetic Rejuvenation across Time and Space. Principal investigator: Thomas Rando, M.D., Ph.D. This program is a research program to discover biological pathways of aging that can be experimentally manipulated to rejuvenate cells and tissues in the body. We will use state-of-the-art technologies to engineer muscles in old mice to restore them to a more youthful state. We will evaluate the success of that process by measuring muscle functions that change with age. To the extent that we are successful in rejuvenating the aged muscle, we will evaluate the impact that has on cells and tissues throughout the body by factors secreted by muscle that travel in the blood to other tissues and organs. At the same time, we will measure biochemical changes in the cells that are known to be associated with aging. It is our hypothesis that those biochemical changes, mostly related to DNA in the nuclei of cells, will also be rejuvenated, The long term impact of these studies will be to develop new treatments for age-related diseases that affect Veterans. 22112191 8615163 PAVIR is privileged to work with a large community of uniquely talented medical researchers across a broad spectrum of research areas as we fulfill our mission of advancing Veterans and public health through innovative research. The range of research activities is broad and includes special emphasis on major disease categories, all of which are prevalent in the VA's patient population. These include cardiovascular medicine, mental health, chronic inflammatory disease, stem cell/regenerative medicine, pain, sleep disorders, and many others. In addition to disease specific research, PAVIR is engaged in supporting research aimed at enhancing health care. PAVIR's research portfolio includes comparative studies in which research teams are learning which treatments are superior to others, how to augment or improve standard of care, as well as how to enhance the operation of health care. Furthermore, PAVIR is supporting educational activities, especially in areas of advancing clinical care for Veterans and fostering the professional development of our expert staff. 22112191 8615163 26191046 1 1 0 0 0 0 0 0 0 0 1 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 0 1 56 0 1 248 1 0 0 0 0 0 0 0 0 0 0 0 0 X 13 2 0 0 0 0 0 1 1 1 1 0 0 1 1 1 1 1 1 1 1 0 CA X Lily Ibragimov 6502392805 3801 Miranda Avenue Palo Alto CA 94304 X Odette Harris Director, Board Chair 1.00 40.00 X X 0 0 0 Paul Heidenreich Director, Secretary/Treasurer 0.50 40.00 X X 0 0 0 Maheen Adamson Director 0.50 40.00 X 0 0 0 Ngan Huang Director 0.50 40.00 X 0 0 0 Ware Kuschner Director from 12/27/22 0.50 40.00 X 0 0 0 Jean Gurga Statutory VA Director 0.50 40.00 X 0 0 0 Andrew R Hoffman Director to 12/26/22 0.50 40.00 X 0 0 0 Lisa Howard Statutory VA Director to 3/31/23 0.50 40.00 X 0 0 0 Meghan Kemnec Statutory Non-VA Director 0.50 X 0 0 0 Mike Kozal Statutory VA Director 0.50 40.00 X 0 0 0 Jennifer Lee Statutory VA Director 0.50 40.00 X 0 0 0 Lawrence Leung Director 0.50 40.00 X 0 0 0 Payam Massaband Statutory VA Director from 7/15/22 0.50 40.00 X 0 0 0 Ferid Murad Director to 1/24/23 0.50 35.00 X 0 0 0 Mark Nicolls Director to 6/10/23 0.50 40.00 X 0 0 0 Robert Sloss Statutory Non-VA Director 0.50 X 0 0 0 Philip Tsao Director 0.50 40.00 X 0 0 0 Elaine Staats CEO 40.00 X 255786 0 48342 Lisa Clark HR Director 40.00 X 181477 0 17293 Lily Ibragimov Director of Finance & Accounting 40.00 X 168662 0 28738 Mary L Thornton Director of Operations 40.00 X 167635 0 28644 Allison Malate Associate Director of Sponsored Research 40.00 X 160378 0 27355 Xinguo Jiang Research Scientist II 40.00 X 147408 0 35433 Calvert Lee Clinical Research Manager 40.00 X 141182 0 36606 Stephanie L Hensey Data Base Analyst II 40.00 X 137955 0 29006 Jenny Nhu-Thuy Dao Accounting Manager 40.00 X 137110 0 32903 Junliang Pan Research Scientist II 40.00 X 132935 0 12391 1630528 0 296711 25 0 1 0 0 18280354 3133242 21413596 Medical research 541700 3773382 3773382 Personnel reimbursements-VAPAHCS 541700 3748648 3748648 Government fees & contracts 541700 1093133 1093133 8615163 450437 450437 Miscellaneous income 900099 24202 24202 24202 30503398 8615163 0 474639 1170537 42905 1127632 12959047 10883312 2075735 796366 644750 151616 1679739 1306644 373095 1053034 840151 212883 48245 47832 413 107102 107102 1418862 1405220 13642 52179 43338 8841 568520 326287 242233 144970 128871 16099 144391 144391 182898 154867 28031 252780 245052 7728 80524 80524 Subrecipients 4710531 4710531 Other personnel cost 2808254 2721247 87007 Research material cost 2291654 2291654 Equipment maintenance 113911 112963 948 153121 141031 12090 30736665 26191046 4545619 0 2249260 2053321 8968218 14201612 3474986 3540479 295245 141049 4015379 3232475 655299 782904 15643008 20719365 3537414 3508152 3932574 9216236 7469988 12724388 X 5680883 6199789 2492137 1795188 8173020 7994977 15643008 20719365 X -233267 57594 -2370 X 0 1 X 1 1 1 X VA Palo Alto Health Care System Palo Alto CA RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED 4015379 3232475 782904 782904 X 30558622 57594 -2370 55224 30503398 0 30503398 30736665 0 30736665 0 30736665 Part X, Line 2: The Organization is a nonprofit corporation exempt from federal income tax under Internal Revenue Code Section 501(c)(3) and state income tax under California Revenue and Taxation Code Section 23701d. However, income from certain activities not directly related to the Organization's tax-exempt purpose may be subject to taxation as unrelated business income. The Organization qualifies for the charitable contribution deduction under IRC Section 170(b)(1)(A)(iii) and has been classified as an Organization that is not a private foundation under Section 509(a)(1). As of September 30, 2023 and 2022, the Organization had no unrecognized tax benefits or uncertain tax positions requiring accrual. Therefore, no provision for income taxes has been provided in the financial statements. Part XI, Line 2d - Other Adjustments: Returned Contributions -2,370. X X 0 0 0 0 0 0 0 0 0 Elaine Staats CEO 255786 0 0 0 0 0 21600 0 26742 0 304128 0 0 0 Lisa Clark HR Director 181477 0 0 0 0 0 16357 0 936 0 198770 0 0 0 Lily Ibragimov Director of Finance & Accounting 168662 0 0 0 0 0 15591 0 13147 0 197400 0 0 0 Mary L Thornton Director of Operations 167635 0 0 0 0 0 15498 0 13146 0 196279 0 0 0 Allison Malate Associate Director of Sponsored Rese 160378 0 0 0 0 0 14593 0 12762 0 187733 0 0 0 Xinguo Jiang Research Scientist II 147408 0 0 0 0 0 13142 0 22291 0 182841 0 0 0 Calvert Lee Clinical Research Manager 141182 0 0 0 0 0 13352 0 23254 0 177788 0 0 0 Jenny Nhu-Thuy Dao Accounting Manager 137110 0 0 0 0 0 13198 0 19705 0 170013 0 0 0 Stephanie L Hensey Data Base Analyst II 137955 0 0 0 0 0 12965 0 16041 0 166961 0 0 0 Form 990, Part VI, Section A, line 7a PAVIR is a nonprofit corporation authorized by Title 38 US Code Sections 7361 through 7366 to be established at and affiliated with the Department of Veterans Affairs Palo Alto Health Care System (VAPAHCS). The referenced statute dictates that four Directors shall be those persons holding the VAPAHCS positions of Director, Chief of Staff, Associate Chief of Staff for Research and Associate Chief of Staff for Education. Form 990, Part VI, Section A, line 7b As stated in response to Form 990, Part VI, Line 7a above, VA has authority to impose requirements and restrictions on the organization through the referenced statute and regulations prescribed by the Secretary of Veterans Affairs. Form 990, Part VI, Section B, line 11b The Form 990 has been provided to all Board members for their review prior to the filing of related tax forms. Form 990, Part VI, Section B, line 12c Directors, officers and key employees complete training in and attest to compliance with PAVIR's conflict of interest policy, as well as disclosing interests which could give rise to conflicts, upon joining PAVIR and annually thereafter. Management tracks the dates, sends reminders and documents receipt of training, attestations, and disclosures, assuring compliance in each calendar year. Form 990, Part VI, Section B, line 15 Annually, PAVIR collects and analyzes market, salary survey and compensation study data based on comparable industry and revenue. The Board's Compensation Committee reviews the data, taking into account performance and accomplishments when establishing the CEO's compensation. The Compensation Committee keeps minutes of its meetings and reports its actions to the full Board. Key employees' salaries are set by the CEO utilizing information from PAVIR's annual salary schedules. Form 990, Part VI, Section C, line 19 The audited financial statements, organizing/governing documents, and conflict of interest policy are available upon written request. Form 990, Part VII and Schedule J, Part II: We wrote to each of the 14 Board members who were compensated by the VA Palo Health Care System requesting permission to obtain his/her compensation information for the calendar year ended December 31, 2022. All members declined in writing to provide their compensation information. None of the Board members received compensation in relation to their duties as Board members of PAVIR. Form 990, Part XI, line 9: Returned contributions -2,370. VA Palo Alto Health Care System 3801 Miranda Avenue Palo Alto CA 94304 941179505 Teaching hospital, providing a full range of patient care services CA 501(c)(1) N/A 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 1 1 0 0 VA Palo Alto Health Care System O 3748648 accrual VA Palo Alto Health Care System P 222093 accrual